Takayasu's arteritis: Difference between revisions

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{{DiseaseDisorder infobox |
  Name          = {{PAGENAME}} |
  ICD10          = {{ICD10|M|31|4|m|30}} |
  ICD9          = {{ICD9|446.7}} |
  ICDO          = |
  Image          = Microscopic takayasu.jpg|
  Caption        = Takayasu's arteritis. <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small>|
  OMIM          = 207600 |
  MedlinePlus    = 001250 |
  eMedicineSubj  = med |
  eMedicineTopic = 2232 |
  eMedicine_mult = {{eMedicine2|ped|1956}} {{eMedicine2|neuro|361}} {{eMedicine2|radio|51}} |
  DiseasesDB    = 12879 |
  MeshID        = D013625 |
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{{Search infobox}}
__NOTOC__
__NOTOC__
'''For  patient information click [[{{PAGENAME}}   (patient information)|here]]'''
{{Takayasu's arteritis}}
{{CMG}}; {{AE}} {{FKH}}, {{SHH}}


{{CMG}}'''; Associate Editor-In-Chief:''' {{CZ}}
{{SK}}Takayasu arteritis; pulseless disease; young female arteritis; young female arteritides; Takayasu syndrome; Takayasu disease; aortitis syndrome


==Overview==
==[[Takayasu's arteritis overview|Overview]]==
'''Takayasu's arteritis''' is an [[inflammation|inflammatory disease]] of unknown [[etiology]] that affects the [[aorta]] and its branches.


==Historical Perspective==
==[[Takayasu's arteritis historical perspective|Historical Perspective]]==
The first case of Takayasu’s arteritis was described in 1908 by Dr. [[Mikito Takayasu]] at the Annual Meeting of the Japan Ophthalmology Society.<ref>{{WhoNamedIt|synd|2722}}</ref><ref>M. Takayasu. A case with peculiar changes of the central retinal vessels. Acta Societatis ophthalmologicae Japonicae, Tokyo 1908, 12: 554.</ref> Dr. Takayasu described a peculiar "wreathlike" appearance of [[blood vessel]]s in the back of the eye ([[retina]]). Two Japanese colleagues at the same meeting (Dr. Onishi and Dr. Kagoshima) reported similar eye findings in patients whose [[Pulse|wrist pulse]]s were absent. It is now known that the blood vessel malformations that occur in the retina are a response ([[angiogenesis|new blood vessel growth]]) to arterial narrowings in the neck, and that the absence of pulses noted in some patients occur because of narrowings of blood vessels to the arms. The eye findings described by Takayasu are rarely seen in patients from North America.


==Symptoms==
==[[Takayasu's arteritis classification|Classification]]==
About half of all patients develop an initial systemic illness with [[symptom]]s of [[malaise]], [[fever]], [[sleep hyperhidrosis|night sweats]], [[weight loss]], [[arthralgia]], and [[fatigue (physical)|fatigue]]. There is often an [[anemia]] and marked elevation of the [[Erythrocyte sedimentation rate|ESR]]. This phase gradually subsides and is followed by a more [[chronic (medicine)|chronic]] stage characterized by inflammatory and obliterative changes in the aorta and its branches. The other half of patients with Takayasu's arteritis present with only late vascular changes, without an antecedent systemic illness. In the late stage, weakness of the arterial walls may give rise to localized [[aneurysm]]s.


Four types of late-phase Takayasu arteritis are described on the basis of the sites of involvement as follows:<ref>{{cite web |url=http://www.emedicine.com/radio/topic51.htm |title=eMedicine - Arteritis, Takayasu : Article by Robert L Cirillo, Jr, MD, MBA |accessdate=2007-07-19 |format= |work=}}</ref>
==[[Takayasu's arteritis pathophysiology|Pathophysiology]]==


* Type I - Classic pulseless type that involves the brachiocephalic trunk, carotid arteries, and subclavian arteries
==[[Takayasu's arteritis causes|Causes]]==
* Type II - Combination of type I and III
* Type III - Atypical coarctation type that involves the thoracic and abdominal aortas distal to the arch and its major branches
* Type IV - Dilated type that involves extensive dilatation of the length of the aorta and its major branches


==Treatment==
==[[Takayasu's arteritis differential diagnosis|Differentiating Takayasu's arteritis  from other Diseases]]==


The great majority of patients with Takayasu’s arteritis respond to [[prednisone]]. The usual starting dose is approximately 1 milligram per kilogram of body weight per day (for most people, this is approximately 60 milligrams a day). Because of the significant [[Adverse effect (medicine)|side effects]] of long-term high–dose prednisone use, the starting dose is tapered over several weeks to a dose that the [[physician]] feels is tolerable for the patient.
==[[Takayasu's arteritis epidemiology and demographics|Epidemiology and Demographics]]==


==References==
==[[Takayasu's arteritis risk factors|Risk Factors]]==
{{Reflist|2}}


==External links==
==[[Takayasu's arteritis screening|Screening]]==
*[http://vasculitis.med.jhu.edu/typesof/takayasu.html Johns Hopkins Vasculitis Center Discusses Takayasu's Arteritis]
*[http://www.takayasus.org Takayasu's Arteritis Research Association]
*[http://www.vasculitisassociation.org Vasculitis Association]
* {{Chorus|00389}}
* {{GPnotebook|-362086386}}
<br>


{{Diseases of the musculoskeletal system and connective tissue}}
==[[Takayasu's arteritis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
{{SIB}}


==Diagnosis==
[[Takayasu's arteritis diagnostic study of choice|Diagnostic study of choice]] | [[Takayasu's arteritis history and symptoms|History and Symptoms]] | [[Takayasu's arteritis physical examination|Physical Examination]] | [[Takayasu's arteritis laboratory findings|Laboratory Findings]] | [[Takayasu's arteritis electrocardiogram|Electrocardiogram]] | [[Takayasu's arteritis x ray|X-Ray]] | [[Takayasu's arteritis echocardiograhy and ultrasound|Echocardiography and Ultrasound]] | [[Takayasu's arteritis CT|CT Scan]] | [[Takayasu's arteritis MRI|MRI Findings]] | [[Takayasu's arteritis other imaging findings|Other Imaging Findings]] | [[Takayasu's arteritis other diagnostic studies|Other Diagnostic Studies]]


[[Category:Angiology]]
==[[Treatment]]==
[[Category:Cardiovascular diseases]]
[[Takayasu's arteritis medical therapy|Medical Therapy]] | [[Takayasu's arteritis surgery|Surgery]] | [[Takayasu's arteritis primary prevention|Primary Prevention]] | [[Takayasu's arteritis secondary prevention|Secondary Prevention]] | [[Takayasu's arteritis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Takayasu's arteritis future or investigational therapies|Future or Investigational Therapies]]
[[Category:Cardiology]]


 
[[Category:Medicine]]
[[de:Takayasu-Arteriitis]]
[[Category:Rheumatology]]
[[fr:Artérite de Takayasu]]
[[Category:Up-To-Date]]
[[ja:大動脈炎症候群]]
[[pl:Zespół Takayasu]]
[[pt:Arterite de Takayasu]]


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Latest revision as of 23:36, 20 May 2021

Takayasu's arteritis Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Takayasu's arteritis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-Ray

Echocardiography and Ultrasound

CT Scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farnaz Khalighinejad, MD [2], Shaghayegh Habibi, M.D.[3]

Synonyms and keywords:Takayasu arteritis; pulseless disease; young female arteritis; young female arteritides; Takayasu syndrome; Takayasu disease; aortitis syndrome

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Takayasu's arteritis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic study of choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-Ray | Echocardiography and Ultrasound | CT Scan | MRI Findings | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies


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