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| {{Infobox_Disease |
| | #redirect:[[Tabes Dorsalis]] |
| Name = {{PAGENAME}} |
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| Image = Tabes dorsalis 1.jpg|
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| Caption = Tabes Dorsalis, degeneration of dorsal columns and dorsal roots at thoracic level <br> <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small>|
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| DiseasesDB = 29061 |
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| ICD10 = {{ICD10|A|52|1|a|50}} |
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| ICD9 = {{ICD9|094.0}} |
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| ICDO = |
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| OMIM = |
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| MedlinePlus = |
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| eMedicineSubj = |
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| eMedicineTopic = |
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| MeshID = D013606 |
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| }}
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| {{Tabes dorsalis (patient information)}}
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| {{CMG}}
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| ==Overview==
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| '''Tabes dorsalis''' is a slow degeneration of the [[nerve cell]]s and nerve fibers that carry sensory information to the [[brain]]. The degenerating nerves are in the [[dorsal columns]] of the [[spinal cord]] (the portion closest to the back of the body) and carry information that help maintain a person's sense of position.
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| ==Cause==
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| Tabes dorsalis is the result of an untreated [[syphilis]] infection.
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| ==Symptoms==
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| Symptoms may not appear for some decades after the initial infection and include: [[weakness]], diminished reflexes, paresthesias including morbid cutaneous sensations having no objective cause, shooting and burning pains, pricking sensations, and formication (a sensation like that produced by small insects crawling over skin), and hypesthesias (abnormally diminished cutaneous, especially tactile, sensory modalities), unsteady gait ([[locomotor ataxia]]), progressive degeneration of the joints, [[loss of coordination]], episodes of intense pain and disturbed sensation (including [[glossodynia]]), personality changes, [[dementia]], [[deafness]], [[visual impairment]], and impaired response to light. The skeletal musculature is hypotonic due to destruction of the sensory limb of the spindle reflex. The deep tendon reflexes are also diminished or absent. For example, the knee jerk or patellar reflex may be lacking, a characteristic finding in tabes known as [[Westphal's sign]].
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| ''Tabes dorsalgia'' is a related back pain.
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| == Prognosis ==
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| If left untreated, tabes dorsalis can lead to [[paralysis]], [[dementia]], and [[blindness]]. Existing nerve damage cannot be reversed.
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| ==Incidence/Prevalence==
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| The disease is more frequent in males than in females. Onset is commonly during mid-life. The incidence of tabes dorsalis is rising, in part due to co-associated [[HIV]] infection.
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| ==Treatment==
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| [[Penicillin]], administered [[intravenous]]ly, is the treatment of choice. Associated pain can be treated with [[opiate]]s, [[valproate]], or [[carbamazepine]]. Patients may also require physical or rehabilitative therapy to deal with muscle wasting and weakness. Preventive treatment for those who come into sexual contact with an individual with tabes dorsalis is important.
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| ==See also==
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| * [[General paresis of the insane]]
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| ==References==
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| * {{NINDS|tabes_dorsalis}}
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| * {{GPnotebook|-1294991357}}
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| * [http://hdl.handle.net/1842/418 'An Essay Upon the Vasomotor Changes in Tabes Dorsalis' by Arthur Conan Doyle]
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| {{SIB}}
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| [[pt:Tabes dorsalis]]
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| {{WikiDoc Help Menu}}
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| [[Category:Neurology]]
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| [[Category:Infectious disease]]
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| [[Category:Pain]]
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| [[Category:Histopathology]]
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| [[Category:Signs and symptoms]]
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| [[Category:Overview complete]]
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