TXNDC5

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.

Function

This gene encodes a protein disulfide-isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MUTED.

Further reading

• Neve EP, Svensson K, Fuxe J, Pettersson RF (Aug 2003). "VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum". Experimental Cell Research. 288 (1): 70–83. doi:10.1016/S0014-4827(03)00161-7. PMID 12878160.
• Knoblach B, Keller BO, Groenendyk J, Aldred S, Zheng J, Lemire BD, Li L, Michalak M (Oct 2003). "ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins". Molecular & Cellular Proteomics. 2 (10): 1104–19. doi:10.1074/mcp.M300053-MCP200. PMID 12930873.
• Sullivan DC, Huminiecki L, Moore JW, Boyle JJ, Poulsom R, Creamer D, Barker J, Bicknell R (Nov 2003). "EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor". The Journal of Biological Chemistry. 278 (47): 47079–88. doi:10.1074/jbc.M308124200. PMID 12963716.
• Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B (Oct 2005). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
• Nissom PM, Lo SL, Lo JC, Ong PF, Lim JW, Ou K, Liang RC, Seow TK, Chung MC (Apr 2006). "Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma". FEBS Letters. 580 (9): 2216–26. doi:10.1016/j.febslet.2006.03.029. PMID 16574106.
• Wang Y, Ma Y, Lü B, Xu E, Huang Q, Lai M (Oct 2007). "Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study". Experimental Biology and Medicine. 232 (9): 1152–9. doi:10.3181/0701-RM-8. PMID 17895523.