TXK (gene): Difference between revisions

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{{Infobox_gene}}
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'''[[Tyrosine]]-[[protein]] [[kinase]] TXK''' is an [[enzyme]] that in [[human]]s is encoded by the TXK [[gene]].<ref name="pmid7951233">{{cite journal |vauthors=Haire RN, Ohta Y, Lewis JE, Fu SM, Kroisel P, Litman GW | title = TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12 | journal = Hum Mol Genet | volume = 3 | issue = 6 | pages = 897–901 |date=Nov 1994 | pmid = 7951233 | pmc =  | doi =10.1093/hmg/3.6.897 }}</ref><ref name="pmid7528718">{{cite journal |vauthors=Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT | title = A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12 | journal = Genomics | volume = 22 | issue = 2 | pages = 431–6 |date=Jan 1995 | pmid = 7528718 | pmc =  | doi = 10.1006/geno.1994.1405 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TXK TXK tyrosine kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7294| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_TXK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dm0.
| PDB = {{PDB2|2dm0}}
| Name = TXK tyrosine kinase
| HGNCid = 12434
| Symbol = TXK
| AltSymbols =; BTKL; MGC22473; PSCTK5; PTK4; RLK; TKL
| OMIM = 600058
| ECnumber =
| Homologene = 2497
| MGIid = 102960
  | GeneAtlas_image1 = PBB_GE_TXK_206828_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
  | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7294
    | Hs_Ensembl = ENSG00000074966
    | Hs_RefseqProtein = NP_003319
    | Hs_RefseqmRNA = NM_003328
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 47762988
    | Hs_GenLoc_end = 47831030
    | Hs_Uniprot = P42681
    | Mm_EntrezGene = 22165
    | Mm_Ensembl = ENSMUSG00000054892
    | Mm_RefseqmRNA = NM_013698
    | Mm_RefseqProtein = NP_038726
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 72975117
    | Mm_GenLoc_end = 73015737
    | Mm_Uniprot = Q0VBP6
  }}
}}
'''TXK tyrosine kinase''', also known as '''TXK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TXK TXK tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7294| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Suzuki N, Nara K, Suzuki T |title=Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. |journal=Clinical medicine & research |volume=4 |issue= 2 |pages= 147-51 |year= 2006 |pmid= 16809408 |doi=  }}
*{{cite journal  |vauthors=Suzuki N, Nara K, Suzuki T |title=Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. |journal=Clinical Medicine & Research |volume=4 |issue= 2 |pages= 147–51 |year= 2006 |pmid= 16809408 |doi=10.3121/cmr.4.2.147 | pmc=1483892 }}
*{{cite journal  | author=Spritz RA, Strunk KM, Lee ST, ''et al.'' |title=A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12. |journal=Genomics |volume=22 |issue= 2 |pages= 431-6 |year= 1995 |pmid= 7528718 |doi= 10.1006/geno.1994.1405 }}
*{{cite journal   |vauthors=Ohta Y, Haire RN, Amemiya CT, etal |title=Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene. |journal=Oncogene |volume=12 |issue= 4 |pages= 937–42 |year= 1996 |pmid= 8632917 |doi=  }}
*{{cite journal | author=Haire RN, Ohta Y, Lewis JE, ''et al.'' |title=TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12. |journal=Hum. Mol. Genet. |volume=3 |issue= 6 |pages= 897-901 |year= 1994 |pmid= 7951233 |doi=  }}
*{{cite journal   |vauthors=Wardenburg JB, Fu C, Jackman JK, etal |title=Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 19641–4 |year= 1996 |pmid= 8702662 |doi=10.1074/jbc.271.33.19641 }}
*{{cite journal | author=Ohta Y, Haire RN, Amemiya CT, ''et al.'' |title=Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene. |journal=Oncogene |volume=12 |issue= 4 |pages= 937-42 |year= 1996 |pmid= 8632917 |doi=  }}
*{{cite journal  |vauthors=Raab M, da Silva AJ, Findell PR, Rudd CE |title=Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. |journal=Immunity |volume=6 |issue= 2 |pages= 155–64 |year= 1997 |pmid= 9047237 |doi=10.1016/S1074-7613(00)80422-7 }}
*{{cite journal | author=Wardenburg JB, Fu C, Jackman JK, ''et al.'' |title=Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 19641-4 |year= 1996 |pmid= 8702662 |doi=  }}
*{{cite journal  |vauthors=Schneider H, Schwartzberg PL, Rudd CE |title=Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 1 |pages= 14–9 |year= 1998 |pmid= 9813138 |doi= 10.1006/bbrc.1998.9559 }}
*{{cite journal  | author=Raab M, da Silva AJ, Findell PR, Rudd CE |title=Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. |journal=Immunity |volume=6 |issue= 2 |pages= 155-64 |year= 1997 |pmid= 9047237 |doi=  }}
*{{cite journal   |vauthors=Rajagopal K, Sommers CL, Decker DC, etal |title=RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. |journal=J. Exp. Med. |volume=190 |issue= 11 |pages= 1657–68 |year= 2000 |pmid= 10587356 |doi=10.1084/jem.190.11.1657  | pmc=2195727 }}
*{{cite journal  | author=Schneider H, Schwartzberg PL, Rudd CE |title=Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 1 |pages= 14-9 |year= 1998 |pmid= 9813138 |doi= 10.1006/bbrc.1998.9559 }}
*{{cite journal  |vauthors=Schneider H, Guerette B, Guntermann C, Rudd CE |title=Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 3835–40 |year= 2000 |pmid= 10660534 |doi=10.1074/jbc.275.6.3835 }}
*{{cite journal | author=Rajagopal K, Sommers CL, Decker DC, ''et al.'' |title=RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. |journal=J. Exp. Med. |volume=190 |issue= 11 |pages= 1657-68 |year= 2000 |pmid= 10587356 |doi=  }}
*{{cite journal   |vauthors=Chamorro M, Czar MJ, Debnath J, etal |title=Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. |journal=BMC Immunol. |volume=2|pages= 3 |year= 2004 |pmid= 11353545 |doi=10.1186/1471-2172-2-3  | pmc=31577 }}
*{{cite journal  | author=Schneider H, Guerette B, Guntermann C, Rudd CE |title=Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 3835-40 |year= 2000 |pmid= 10660534 |doi=  }}
*{{cite journal   |vauthors=Takeba Y, Nagafuchi H, Takeno M, etal |title=Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription. |journal=J. Immunol. |volume=168 |issue= 5 |pages= 2365–70 |year= 2002 |pmid= 11859127 |doi=  10.4049/jimmunol.168.5.2365}}
*{{cite journal | author=Chamorro M, Czar MJ, Debnath J, ''et al.'' |title=Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. |journal=BMC Immunol. |volume=2 |issue=  |pages= 3 |year= 2004 |pmid= 11353545 |doi=  }}
*{{cite journal   |vauthors=Kashiwakura J, Suzuki N, Takeno M, etal |title=Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site. |journal=Biol. Pharm. Bull. |volume=25 |issue= 6 |pages= 718–21 |year= 2002 |pmid= 12081135 |doi=10.1248/bpb.25.718 }}
*{{cite journal | author=Takeba Y, Nagafuchi H, Takeno M, ''et al.'' |title=Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription. |journal=J. Immunol. |volume=168 |issue= 5 |pages= 2365-70 |year= 2002 |pmid= 11859127 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Kashiwakura J, Suzuki N, Takeno M, ''et al.'' |title=Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site. |journal=Biol. Pharm. Bull. |volume=25 |issue= 6 |pages= 718-21 |year= 2002 |pmid= 12081135 |doi=  }}
*{{cite journal   |vauthors=Rafalska I, Zhang Z, Benderska N, etal |title=The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation. |journal=Hum. Mol. Genet. |volume=13 |issue= 15 |pages= 1535–49 |year= 2005 |pmid= 15175272 |doi= 10.1093/hmg/ddh167 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Rafalska I, Zhang Z, Benderska N, ''et al.'' |title=The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation. |journal=Hum. Mol. Genet. |volume=13 |issue= 15 |pages= 1535-49 |year= 2005 |pmid= 15175272 |doi= 10.1093/hmg/ddh167 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
}}
{{refend}}
{{refend}}


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[[Category:Tyrosine kinases]]
 
 
{{gene-4-stub}}

Latest revision as of 12:06, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tyrosine-protein kinase TXK is an enzyme that in humans is encoded by the TXK gene.[1][2][3]


References

  1. ↑ Haire RN, Ohta Y, Lewis JE, Fu SM, Kroisel P, Litman GW (Nov 1994). "TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12". Hum Mol Genet. 3 (6): 897–901. doi:10.1093/hmg/3.6.897. PMID 7951233.
  2. ↑ Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics. 22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID 7528718.
  3. ↑ "Entrez Gene: TXK TXK tyrosine kinase".

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=TXK_(gene)&oldid=1526343"