Difference between revisions of "TUBA8"

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{{Infobox_gene}}
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'''Tubulin alpha-8 chain''' is a [[protein]] that in humans is encoded by the ''TUBA8'' [[gene]].<ref name="pmid10772959">{{cite journal | vauthors = Stanchi F, Corso V, Scannapieco P, Ievolella C, Negrisolo E, Tiso N, Lanfranchi G, Valle G | title = TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse | journal = Biochem Biophys Res Commun | volume = 270 | issue = 3 | pages = 1111–8 |date=May 2000 | pmid = 10772959 | pmc =  | doi = 10.1006/bbrc.2000.2571 }}</ref><ref name="pmid10591208">{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP| title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 |date=Dec 1999 | pmid = 10591208 | pmc =  | doi = 10.1038/990031 |display-authors=etal}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TUBA8 tubulin, alpha 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51807| accessdate = }}</ref><ref name="genecards">{{cite web | title = GeneCards: TUBA8 gene| url = https://www.genecards.org/cgi-bin/carddisp.pl?gene=TUBA8| accessdate = }}</ref>
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{{GNF_Protein_box
 
| image = PBB_Protein_TUBA8_image.jpg
 
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1tub.
 
| PDB = {{PDB2|1tub}}, {{PDB2|1tvk}}, {{PDB2|1z2b}}
 
| Name = Tubulin, alpha 8
 
| HGNCid = 12410
 
| Symbol = TUBA8
 
| AltSymbols =; TUBAL2
 
| OMIM = 605742
 
| ECnumber = 
 
| Homologene = 56766
 
| MGIid = 1858225
 
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
 
  | Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
 
| Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0051258 |text = protein polymerization}}
 
| Orthologs = {{GNF_Ortholog_box
 
    | Hs_EntrezGene = 51807
 
    | Hs_Ensembl =
 
    | Hs_RefseqProtein = NP_061816
 
    | Hs_RefseqmRNA = NM_018943
 
    | Hs_GenLoc_db =   
 
    | Hs_GenLoc_chr =
 
    | Hs_GenLoc_start = 
 
    | Hs_GenLoc_end = 
 
    | Hs_Uniprot = 
 
    | Mm_EntrezGene = 53857
 
    | Mm_Ensembl = ENSMUSG00000030137
 
    | Mm_RefseqmRNA = NM_017379
 
    | Mm_RefseqProtein = NP_059075
 
    | Mm_GenLoc_db = 
 
    | Mm_GenLoc_chr = 6
 
    | Mm_GenLoc_start = 121186003
 
    | Mm_GenLoc_end = 121191698
 
    | Mm_Uniprot = Q9JJZ2
 
  }}
 
}}
 
'''Tubulin, alpha 8''', also known as '''TUBA8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TUBA8 tubulin, alpha 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51807| accessdate = }}</ref>
 
  
 
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==References==
 
==References==
 
{{reflist}}
 
{{reflist}}
 +
 
==Further reading==
 
==Further reading==
 
{{refbegin | 2}}
 
{{refbegin | 2}}
 
{{PBB_Further_reading  
 
{{PBB_Further_reading  
 
| citations =  
 
| citations =  
*{{cite journal | author=Alexandrova N, Niklinski J, Bliskovsky V, ''et al.'' |title=The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5188-95 |year= 1995 |pmid= 7651436 |doi=  }}
+
*{{cite journal   |vauthors=Alexandrova N, Niklinski J, Bliskovsky V, etal |title=The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5188–95 |year= 1995 |pmid= 7651436 |doi= | pmc=230766 }}
*{{cite journal  | author=Feierbach B, Nogales E, Downing KH, Stearns T |title=Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin. |journal=J. Cell Biol. |volume=144 |issue= 1 |pages= 113-24 |year= 1999 |pmid= 9885248 |doi=  }}
+
*{{cite journal  | vauthors=Feierbach B, Nogales E, Downing KH, Stearns T |title=Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin. |journal=J. Cell Biol. |volume=144 |issue= 1 |pages= 113–24 |year= 1999 |pmid= 9885248 |doi=10.1083/jcb.144.1.113  | pmc=2148126  }}
*{{cite journal  | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
+
*{{cite journal   |vauthors=Herreros L, Rodríguez-Fernandez JL, Brown MC, etal |title=Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26436–40 |year= 2000 |pmid= 10840040 |doi= 10.1074/jbc.M003970200 }}
*{{cite journal  | author=Stanchi F, Corso V, Scannapieco P, ''et al.'' |title=TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse. |journal=Biochem. Biophys. Res. Commun. |volume=270 |issue= 3 |pages= 1111-8 |year= 2000 |pmid= 10772959 |doi= 10.1006/bbrc.2000.2571 }}
+
*{{cite journal   |vauthors=Watts NR, Sackett DL, Ward RD, etal |title=HIV-1 rev depolymerizes microtubules to form stable bilayered rings. |journal=J. Cell Biol. |volume=150 |issue= 2 |pages= 349–60 |year= 2000 |pmid= 10908577 |doi=10.1083/jcb.150.2.349  | pmc=2180222 }}
*{{cite journal | author=Herreros L, Rodríguez-Fernandez JL, Brown MC, ''et al.'' |title=Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26436-40 |year= 2000 |pmid= 10840040 |doi= 10.1074/jbc.M003970200 }}
+
*{{cite journal   |vauthors=Germani A, Bruzzoni-Giovanelli H, Fellous A, etal |title=SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. |journal=Oncogene |volume=19 |issue= 52 |pages= 5997–6006 |year= 2001 |pmid= 11146551 |doi= 10.1038/sj.onc.1204002 }}
*{{cite journal | author=Watts NR, Sackett DL, Ward RD, ''et al.'' |title=HIV-1 rev depolymerizes microtubules to form stable bilayered rings. |journal=J. Cell Biol. |volume=150 |issue= 2 |pages= 349-60 |year= 2000 |pmid= 10908577 |doi=  }}
+
*{{cite journal   |vauthors=Saugstad JA, Yang S, Pohl J, etal |title=Interaction between metabotropic glutamate receptor 7 and alpha tubulin. |journal=J. Neurochem. |volume=80 |issue= 6 |pages= 980–8 |year= 2002 |pmid= 11953448 | pmc=2925652 |doi=10.1046/j.0022-3042.2002.00778.x }}
*{{cite journal | author=Germani A, Bruzzoni-Giovanelli H, Fellous A, ''et al.'' |title=SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. |journal=Oncogene |volume=19 |issue= 52 |pages= 5997-6006 |year= 2001 |pmid= 11146551 |doi= 10.1038/sj.onc.1204002 }}
+
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Saugstad JA, Yang S, Pohl J, ''et al.'' |title=Interaction between metabotropic glutamate receptor 7 and alpha tubulin. |journal=J. Neurochem. |volume=80 |issue= 6 |pages= 980-8 |year= 2002 |pmid= 11953448 |doi=  }}
+
*{{cite journal  | vauthors=Chen D, Wang M, Zhou S, Zhou Q |title=HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim. |journal=EMBO J. |volume=21 |issue= 24 |pages= 6801–10 |year= 2004 |pmid= 12486001 |doi=10.1093/emboj/cdf683  | pmc=139103 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Chen D, Wang M, Zhou S, Zhou Q |title=HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim. |journal=EMBO J. |volume=21 |issue= 24 |pages= 6801-10 |year= 2004 |pmid= 12486001 |doi=  }}
+
*{{cite journal   |vauthors=Xu Y, Kulkosky J, Acheampong E, etal |title=HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 18 |pages= 7070–5 |year= 2004 |pmid= 15103018 |doi= 10.1073/pnas.0304859101 | pmc=406467 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+
*{{cite journal   |vauthors=Campbell GR, Pasquier E, Watkins J, etal |title=The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis. |journal=J. Biol. Chem. |volume=279 |issue= 46 |pages= 48197–204 |year= 2005 |pmid= 15331610 |doi= 10.1074/jbc.M406195200 }}
*{{cite journal | author=Xu Y, Kulkosky J, Acheampong E, ''et al.'' |title=HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 18 |pages= 7070-5 |year= 2004 |pmid= 15103018 |doi= 10.1073/pnas.0304859101 }}
+
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite journal | author=Campbell GR, Pasquier E, Watkins J, ''et al.'' |title=The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis. |journal=J. Biol. Chem. |volume=279 |issue= 46 |pages= 48197-204 |year= 2005 |pmid= 15331610 |doi= 10.1074/jbc.M406195200 }}
+
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
+
*{{cite journal   |vauthors=de Mareuil J, Carre M, Barbier P, etal |title=HIV-1 Tat protein enhances microtubule polymerization. |journal=Retrovirology |volume=2 |issue=  |pages= 5 |year= 2006 |pmid= 15691386 |doi= 10.1186/1742-4690-2-5 | pmc=549075 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+
*{{cite journal  | author=Giacca M |title=HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? |journal=Retrovirology |volume=2 |issue=  |pages= 7 |year= 2006 |pmid= 15698476 |doi= 10.1186/1742-4690-2-7 | pmc=549042 }}
*{{cite journal | author=de Mareuil J, Carre M, Barbier P, ''et al.'' |title=HIV-1 Tat protein enhances microtubule polymerization. |journal=Retrovirology |volume=2 |issue=  |pages= 5 |year= 2006 |pmid= 15691386 |doi= 10.1186/1742-4690-2-5 }}
+
*{{cite journal   |vauthors=Valenzuela-Fernández A, Alvarez S, Gordon-Alonso M, etal |title=Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. |journal=Mol. Biol. Cell |volume=16 |issue= 11 |pages= 5445–54 |year= 2006 |pmid= 16148047 |doi= 10.1091/mbc.E05-04-0354 | pmc=1266439 }}
*{{cite journal  | author=Giacca M |title=HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? |journal=Retrovirology |volume=2 |issue=  |pages= 7 |year= 2006 |pmid= 15698476 |doi= 10.1186/1742-4690-2-7 }}
+
*{{cite journal   |vauthors=Canani RB, De Marco G, Passariello A, etal |title=Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells. |journal=AIDS |volume=20 |issue= 1 |pages= 5–10 |year= 2006 |pmid= 16327313 |doi=10.1097/01.aids.0000198088.85572.68 }}
*{{cite journal | author=Valenzuela-Fernández A, Alvarez S, Gordon-Alonso M, ''et al.'' |title=Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. |journal=Mol. Biol. Cell |volume=16 |issue= 11 |pages= 5445-54 |year= 2006 |pmid= 16148047 |doi= 10.1091/mbc.E05-04-0354 }}
 
*{{cite journal | author=Canani RB, De Marco G, Passariello A, ''et al.'' |title=Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells. |journal=AIDS |volume=20 |issue= 1 |pages= 5-10 |year= 2006 |pmid= 16327313 |doi=  }}
 
 
}}
 
}}
 
{{refend}}
 
{{refend}}
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{{PDB Gallery|geneid=51807}}
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Latest revision as of 12:27, 9 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tubulin alpha-8 chain is a protein that in humans is encoded by the TUBA8 gene.[1][2][3][4]


References

  1. Stanchi F, Corso V, Scannapieco P, Ievolella C, Negrisolo E, Tiso N, Lanfranchi G, Valle G (May 2000). "TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse". Biochem Biophys Res Commun. 270 (3): 1111–8. doi:10.1006/bbrc.2000.2571. PMID 10772959.
  2. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  3. "Entrez Gene: TUBA8 tubulin, alpha 8".
  4. "GeneCards: TUBA8 gene".

Further reading




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