TUBA1B: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Tubulin alpha-1B chain''' is a [[protein]] that in humans is encoded by the ''TUBA1B'' [[gene]].<ref name="pmid12054644">{{cite journal | author = Banerjee A | title = Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells | journal = Biochem Biophys Res Commun | volume = 293 | issue = 1 | pages = 598–601 |date=Jun 2002 | pmid = 12054644 | pmc =  | doi = 10.1016/S0006-291X(02)00269-3 }}</ref><ref name="pmid6646120">{{cite journal |vauthors=Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW | title = Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions | journal = Mol Cell Biol | volume = 3 | issue = 10 | pages = 1738–45 |date=Jan 1984 | pmid = 6646120 | pmc = 370035 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TUBA1B tubulin, alpha 1b| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10376| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_TUBA1B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ffx.
| PDB = {{PDB2|1ffx}}, {{PDB2|1ia0}}, {{PDB2|1jff}}, {{PDB2|1sa0}}, {{PDB2|1sa1}}, {{PDB2|1tub}}, {{PDB2|1tvk}}, {{PDB2|1z2b}}, {{PDB2|2hxf}}, {{PDB2|2hxh}}
| Name = Tubulin, alpha 1b
| HGNCid = 18809
| Symbol = TUBA1B
| AltSymbols =; K-ALPHA-1
| OMIM = 602530
| ECnumber =
| Homologene = 81745
| MGIid = 107804
  | GeneAtlas_image1 = PBB_GE_TUBA1B_201090_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_TUBA1B_209251_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_TUBA1B_211058_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0051258 |text = protein polymerization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10376
    | Hs_Ensembl = ENSG00000123416
    | Hs_RefseqProtein = NP_006073
    | Hs_RefseqmRNA = NM_006082
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 47807836
    | Hs_GenLoc_end = 47811571
    | Hs_Uniprot = P68363
    | Mm_EntrezGene = 22143
    | Mm_Ensembl =
    | Mm_RefseqmRNA = NM_011654
    | Mm_RefseqProtein = NP_035784
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr =   
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Tubulin, alpha 1b''', also known as '''TUBA1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TUBA1B tubulin, alpha 1b| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10376| accessdate = }}</ref>
 
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| summary_text =  
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==Interactions==
TUBA1B has been shown to [[Protein-protein interaction|interact]] with [[PIK3R1]].<ref name=pmid7592789>{{cite journal |doi=10.1074/jbc.270.43.25985 |last=Kapeller |first=R |authorlink= |author2=Toker A |author3=Cantley L C |author4=Carpenter C L  |date=Oct 1995 |title=Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin |journal=J. Biol. Chem. |volume=270 |issue=43 |pages=25985–91 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 7592789 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
Antibodies against tubulin alpha 1b can be used as markers for microtubules and spindles.<ref>http://www.genetex.com/WebPage/Product/PromotionDetail.aspx?Type=Promotion&PromotionID=178</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Venter JC |title=Identification of new human receptor and transporter genes by high throughput cDNA (EST) sequencing. |journal=J. Pharm. Pharmacol. |volume=45 Suppl 1 |issue=  |pages= 355-60 |year= 1993 |pmid= 8098743 |doi=  }}
*{{cite journal  | author=Venter JC |title=Identification of new human receptor and transporter genes by high throughput cDNA (EST) sequencing. | series=45 |journal=J. Pharm. Pharmacol. |volume=Suppl 1 |issue=  |pages= 355–60 |year= 1993 |pmid= 8098743 |doi=  }}
*{{cite journal | author=Lopez-Fanarraga M, Avila J, Guasch A, ''et al.'' |title=Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics. |journal=J. Struct. Biol. |volume=135 |issue= 2 |pages= 219-29 |year= 2002 |pmid= 11580271 |doi= 10.1006/jsbi.2001.4386 }}
*{{cite journal   |vauthors=Lopez-Fanarraga M, Avila J, Guasch A, etal |title=Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics. |journal=J. Struct. Biol. |volume=135 |issue= 2 |pages= 219–29 |year= 2002 |pmid= 11580271 |doi= 10.1006/jsbi.2001.4386 }}
*{{cite journal  | author=Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW |title=Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. |journal=Mol. Cell. Biol. |volume=3 |issue= 10 |pages= 1738-45 |year= 1984 |pmid= 6646120 |doi=  }}
*{{cite journal  |vauthors=Kapeller R, Toker A, Cantley LC, Carpenter CL |title=Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. |journal=J. Biol. Chem. |volume=270 |issue= 43 |pages= 25985–91 |year= 1995 |pmid= 7592789 |doi=10.1074/jbc.270.43.25985 }}
*{{cite journal  | author=Kapeller R, Toker A, Cantley LC, Carpenter CL |title=Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. |journal=J. Biol. Chem. |volume=270 |issue= 43 |pages= 25985-91 |year= 1995 |pmid= 7592789 |doi=  }}
*{{cite journal   |vauthors=Alexandrova N, Niklinski J, Bliskovsky V, etal |title=The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5188–95 |year= 1995 |pmid= 7651436 |doi= | pmc=230766 }}
*{{cite journal | author=Alexandrova N, Niklinski J, Bliskovsky V, ''et al.'' |title=The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5188-95 |year= 1995 |pmid= 7651436 |doi=  }}
*{{cite journal  |vauthors=Szasz J, Yaffe MB, Sternlicht H |title=Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region. |journal=Biophys. J. |volume=64 |issue= 3 |pages= 792–802 |year= 1993 |pmid= 8097117 |doi=10.1016/S0006-3495(93)81440-1  | pmc=1262393 }}
*{{cite journal  | author=Szasz J, Yaffe MB, Sternlicht H |title=Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region. |journal=Biophys. J. |volume=64 |issue= 3 |pages= 792-802 |year= 1993 |pmid= 8097117 |doi=  }}
*{{cite journal   |vauthors=Baumann MH, Wisniewski T, Levy E, etal |title=C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type. |journal=Biochem. Biophys. Res. Commun. |volume=219 |issue= 1 |pages= 238–42 |year= 1996 |pmid= 8619814 |doi= 10.1006/bbrc.1996.0211 }}
*{{cite journal | author=Baumann MH, Wisniewski T, Levy E, ''et al.'' |title=C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type. |journal=Biochem. Biophys. Res. Commun. |volume=219 |issue= 1 |pages= 238-42 |year= 1996 |pmid= 8619814 |doi= 10.1006/bbrc.1996.0211 }}
*{{cite journal   |vauthors=Gress TM, Müller-Pillasch F, Geng M, etal |title=A pancreatic cancer-specific expression profile. |journal=Oncogene |volume=13 |issue= 8 |pages= 1819–30 |year= 1996 |pmid= 8895530 |doi=  }}
*{{cite journal | author=Gress TM, Müller-Pillasch F, Geng M, ''et al.'' |title=A pancreatic cancer-specific expression profile. |journal=Oncogene |volume=13 |issue= 8 |pages= 1819-30 |year= 1996 |pmid= 8895530 |doi=  }}
*{{cite journal   |vauthors=Crépieux P, Kwon H, Leclerc N, etal |title=I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 7375–85 |year= 1997 |pmid= 9372968 |doi= | pmc=232593 }}
*{{cite journal | author=Crépieux P, Kwon H, Leclerc N, ''et al.'' |title=I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 7375-85 |year= 1997 |pmid= 9372968 |doi=  }}
*{{cite journal   |vauthors=Herreros L, Rodríguez-Fernandez JL, Brown MC, etal |title=Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26436–40 |year= 2000 |pmid= 10840040 |doi= 10.1074/jbc.M003970200 }}
*{{cite journal | author=Herreros L, Rodríguez-Fernandez JL, Brown MC, ''et al.'' |title=Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26436-40 |year= 2000 |pmid= 10840040 |doi= 10.1074/jbc.M003970200 }}
*{{cite journal   |vauthors=Watts NR, Sackett DL, Ward RD, etal |title=HIV-1 rev depolymerizes microtubules to form stable bilayered rings. |journal=J. Cell Biol. |volume=150 |issue= 2 |pages= 349–60 |year= 2000 |pmid= 10908577 |doi=10.1083/jcb.150.2.349  | pmc=2180222 }}
*{{cite journal | author=Watts NR, Sackett DL, Ward RD, ''et al.'' |title=HIV-1 rev depolymerizes microtubules to form stable bilayered rings. |journal=J. Cell Biol. |volume=150 |issue= 2 |pages= 349-60 |year= 2000 |pmid= 10908577 |doi=  }}
*{{cite journal  |vauthors=Takeoka A, Shimizu M, Horio T |title=Identification of an alpha-tubulin mutant of fission yeast from gamma-tubulin-interacting protein screening: genetic evidence for alpha-/gamma-tubulin interaction. | series=113 |journal=J. Cell Sci. |volume=Pt 24 |issue=  |pages= 4557–62 |year= 2001 |pmid= 11082048 |doi=  }}
*{{cite journal  | author=Takeoka A, Shimizu M, Horio T |title=Identification of an alpha-tubulin mutant of fission yeast from gamma-tubulin-interacting protein screening: genetic evidence for alpha-/gamma-tubulin interaction. |journal=J. Cell. Sci. |volume=113 Pt 24 |issue=  |pages= 4557-62 |year= 2001 |pmid= 11082048 |doi=  }}
*{{cite journal   |vauthors=Germani A, Bruzzoni-Giovanelli H, Fellous A, etal |title=SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. |journal=Oncogene |volume=19 |issue= 52 |pages= 5997–6006 |year= 2001 |pmid= 11146551 |doi= 10.1038/sj.onc.1204002 }}
*{{cite journal | author=Germani A, Bruzzoni-Giovanelli H, Fellous A, ''et al.'' |title=SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. |journal=Oncogene |volume=19 |issue= 52 |pages= 5997-6006 |year= 2001 |pmid= 11146551 |doi= 10.1038/sj.onc.1204002 }}
*{{cite journal  |vauthors=Yokota S, Yanagi H, Yura T, Kubota H |title=Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle. |journal=Eur. J. Biochem. |volume=268 |issue= 17 |pages= 4664–73 |year= 2001 |pmid= 11532003 |doi=10.1046/j.1432-1327.2001.02393.x }}
*{{cite journal  | author=Yokota S, Yanagi H, Yura T, Kubota H |title=Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle. |journal=Eur. J. Biochem. |volume=268 |issue= 17 |pages= 4664-73 |year= 2001 |pmid= 11532003 |doi=  }}
*{{cite journal   |vauthors=Rommelaere H, De Neve M, Neirynck K, etal |title=Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41023–8 |year= 2001 |pmid= 11535601 |doi= 10.1074/jbc.M106591200 }}
*{{cite journal | author=Rommelaere H, De Neve M, Neirynck K, ''et al.'' |title=Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41023-8 |year= 2001 |pmid= 11535601 |doi= 10.1074/jbc.M106591200 }}
*{{cite journal   |vauthors=Klein C, Kramer EM, Cardine AM, etal |title=Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. |journal=J. Neurosci. |volume=22 |issue= 3 |pages= 698–707 |year= 2002 |pmid= 11826099 |doi=  }}
*{{cite journal | author=Klein C, Kramer EM, Cardine AM, ''et al.'' |title=Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. |journal=J. Neurosci. |volume=22 |issue= 3 |pages= 698-707 |year= 2002 |pmid= 11826099 |doi=  }}
*{{cite journal   |vauthors=Saugstad JA, Yang S, Pohl J, etal |title=Interaction between metabotropic glutamate receptor 7 and alpha tubulin. |journal=J. Neurochem. |volume=80 |issue= 6 |pages= 980–8 |year= 2002 |pmid= 11953448  | pmc=2925652 |doi=10.1046/j.0022-3042.2002.00778.x  }}
*{{cite journal | author=Saugstad JA, Yang S, Pohl J, ''et al.'' |title=Interaction between metabotropic glutamate receptor 7 and alpha tubulin. |journal=J. Neurochem. |volume=80 |issue= 6 |pages= 980-8 |year= 2002 |pmid= 11953448 |doi=  }}
*{{cite journal | author=Banerjee A |title=Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 598-601 |year= 2002 |pmid= 12054644 |doi= 10.1016/S0006-291X(02)00269-3 }}
}}
}}
{{refend}}
{{refend}}


{{WH}}
==External links==
{{WS}}
* {{UCSC genome browser|TUBA1B}}
* {{UCSC gene details|TUBA1B}}
 
{{PDB Gallery|geneid=10376}}
 
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{{gene-12-stub}}

Revision as of 21:04, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.[1][2][3]


Interactions

TUBA1B has been shown to interact with PIK3R1.[4] Antibodies against tubulin alpha 1b can be used as markers for microtubules and spindles.[5]

References

  1. ↑ Banerjee A (Jun 2002). "Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells". Biochem Biophys Res Commun. 293 (1): 598–601. doi:10.1016/S0006-291X(02)00269-3. PMID 12054644.
  2. ↑ Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (Jan 1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Mol Cell Biol. 3 (10): 1738–45. PMC 370035. PMID 6646120.
  3. ↑ "Entrez Gene: TUBA1B tubulin, alpha 1b".
  4. ↑ Kapeller, R; Toker A; Cantley L C; Carpenter C L (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". J. Biol. Chem. UNITED STATES. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. ISSN 0021-9258. PMID 7592789.
  5. ↑ http://www.genetex.com/WebPage/Product/PromotionDetail.aspx?Type=Promotion&PromotionID=178

Further reading

External links



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