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*{{cite journal |vauthors=Girdham CH, Glover DM |title=Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein |journal=Genes Dev. |volume=5 |issue= 10 |pages= 1786–99 |year= 1991 |pmid= 1916263 |doi=10.1101/gad.5.10.1786 }} | *{{cite journal |vauthors=Girdham CH, Glover DM |title=Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein |journal=Genes Dev. |volume=5 |issue= 10 |pages= 1786–99 |year= 1991 |pmid= 1916263 |doi=10.1101/gad.5.10.1786 }} | ||
*{{cite journal |vauthors=Hara R, Selby CP, Liu M, etal |title=Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24779–86 |year= 1999 |pmid= 10455150 |doi=10.1074/jbc.274.35.24779 }} | *{{cite journal |vauthors=Hara R, Selby CP, Liu M, etal |title=Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24779–86 |year= 1999 |pmid= 10455150 |doi=10.1074/jbc.274.35.24779 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793–801 |year= 2003 |pmid= 12927788 |doi=10.1016/S0006-291X(03)01486-4 }} | *{{cite journal |vauthors=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793–801 |year= 2003 |pmid= 12927788 |doi=10.1016/S0006-291X(03)01486-4 }} | ||
*{{cite journal |vauthors=Jiang Y, Liu M, Spencer CA, Price DH |title=Involvement of transcription termination factor 2 in mitotic repression of transcription elongation |journal=Mol. Cell |volume=14 |issue= 3 |pages= 375–85 |year= 2004 |pmid= 15125840 |doi=10.1016/S1097-2765(04)00234-5 }} | *{{cite journal |vauthors=Jiang Y, Liu M, Spencer CA, Price DH |title=Involvement of transcription termination factor 2 in mitotic repression of transcription elongation |journal=Mol. Cell |volume=14 |issue= 3 |pages= 375–85 |year= 2004 |pmid= 15125840 |doi=10.1016/S1097-2765(04)00234-5 }} | ||
| Line 26: | Line 26: | ||
*{{cite journal |vauthors=Jiang Y, Price DH |title=Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector |journal=Cell Cycle |volume=3 |issue= 9 |pages= 1151–3 |year= 2006 |pmid= 15467445 |doi= 10.4161/cc.3.9.1151 }} | *{{cite journal |vauthors=Jiang Y, Price DH |title=Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector |journal=Cell Cycle |volume=3 |issue= 9 |pages= 1151–3 |year= 2006 |pmid= 15467445 |doi= 10.4161/cc.3.9.1151 }} | ||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }} | *{{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G }} | ||
}} | }} | ||
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Latest revision as of 19:18, 26 June 2018
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Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.[1][2]
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.[2]
Interactions
TTF2 has been shown to interact with CDC5L.[3]
References
- ↑ Liu M, Xie Z, Price DH (Nov 1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member". J Biol Chem. 273 (40): 25541–4. doi:10.1074/jbc.273.40.25541. PMID 9748214.
- ↑ 2.0 2.1 "Entrez Gene: TTF2 transcription termination factor, RNA polymerase II".
- ↑ Leonard, Deana; Ajuh Paul; Lamond Angus I; Legerski Randy J (Sep 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. United States. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. ISSN 0006-291X. PMID 12927788.
Further reading
- Girdham CH, Glover DM (1991). "Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein". Genes Dev. 5 (10): 1786–99. doi:10.1101/gad.5.10.1786. PMID 1916263.
- Hara R, Selby CP, Liu M, et al. (1999). "Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer". J. Biol. Chem. 274 (35): 24779–86. doi:10.1074/jbc.274.35.24779. PMID 10455150.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
- Jiang Y, Liu M, Spencer CA, Price DH (2004). "Involvement of transcription termination factor 2 in mitotic repression of transcription elongation". Mol. Cell. 14 (3): 375–85. doi:10.1016/S1097-2765(04)00234-5. PMID 15125840.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Jiang Y, Price DH (2006). "Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector". Cell Cycle. 3 (9): 1151–3. doi:10.4161/cc.3.9.1151. PMID 15467445.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
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