TNNT2

Troponin T type 2 (cardiac)
File:PBB Protein TNNT2 image.jpg PDB rendering based on 1j1d.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1j1d​, 1j1e​
Identifiers
Symbols	TNNT2 ; CMH2; MGC3889; TnTC; cTnT
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68050
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TNNT2 215389 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Troponin T type 2 (cardiac), also known as TNNT2, is a human gene.

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.

Further reading

• Gomes AV, Barnes JA, Harada K, Potter JD (2005). "Role of troponin T in disease". Mol. Cell. Biochem. 263 (1–2): 115–29. PMID 15524172.CS1 maint: Multiple names: authors list (link)
• Noland TA, Raynor RL, Kuo JF (1990). "Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites". J. Biol. Chem. 264 (34): 20778–85. PMID 2584239.CS1 maint: Multiple names: authors list (link)
• Breitbart RE, Nadal-Ginard B (1987). "Developmentally induced, muscle-specific trans factors control the differential splicing of alternative and constitutive troponin T exons". Cell. 49 (6): 793–803. PMID 3581171.
• Medford RM, Nguyen HT, Destree AT; et al. (1984). "A novel mechanism of alternative RNA splicing for the developmentally regulated generation of troponin T isoforms from a single gene". Cell. 38 (2): 409–21. PMID 6205765.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanokura M, Ohtsuki I (1984). "Interactions among chymotryptic troponin T subfragments, tropomyosin, troponin I and troponin C.". J. Biochem. 95 (5): 1417–21. PMID 6746613.
• Pearlstone JR, Smillie LB (1983). "Effects of troponin-I plus-C on the binding of troponin-T and its fragments to alpha-tropomyosin. Ca2+ sensitivity and cooperativity". J. Biol. Chem. 258 (4): 2534–42. PMID 6822572.
• Kovalyov LI, Shishkin SS, Efimochkin AS; et al. (1996). "The major protein expression profile and two-dimensional protein database of human heart". Electrophoresis. 16 (7): 1160–9. PMID 7498159.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anderson PA, Greig A, Mark TM; et al. (1995). "Molecular basis of human cardiac troponin T isoforms expressed in the developing, adult, and failing heart". Circ. Res. 76 (4): 681–6. PMID 7534662.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mesnard L, Logeart D, Taviaux S; et al. (1995). "Human cardiac troponin T: cloning and expression of new isoforms in the normal and failing heart". Circ. Res. 76 (4): 687–92. PMID 7895342.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Watkins H, McKenna WJ, Thierfelder L; et al. (1995). "Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy". N. Engl. J. Med. 332 (16): 1058–64. PMID 7898523.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Watkins H, MacRae C, Thierfelder L; et al. (1995). "A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3". Nat. Genet. 3 (4): 333–7. doi:10.1038/ng0493-333. PMID 7981753.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Townsend PJ, Farza H, MacGeoch C; et al. (1994). "Human cardiac troponin T: identification of fetal isoforms and assignment of the TNNT2 locus to chromosome 1q". Genomics. 21 (2): 311–6. doi:10.1006/geno.1994.1271. PMID 8088824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thierfelder L, Watkins H, MacRae C; et al. (1994). "Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere". Cell. 77 (5): 701–12. PMID 8205619.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mesnard L, Samson F, Espinasse I; et al. (1993). "Molecular cloning and developmental expression of human cardiac troponin T.". FEBS Lett. 328 (1–2): 139–44. PMID 8344420.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Durand JB, Bachinski LL, Bieling LC; et al. (1996). "Localization of a gene responsible for familial dilated cardiomyopathy to chromosome 1q32". Circulation. 92 (12): 3387–9. PMID 8521556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Townsend PJ, Barton PJ, Yacoub MH, Farza H (1996). "Molecular cloning of human cardiac troponin T isoforms: expression in developing and failing heart". J. Mol. Cell. Cardiol. 27 (10): 2223–36. PMID 8576938.CS1 maint: Multiple names: authors list (link)
• Jideama NM, Noland TA, Raynor RL; et al. (1996). "Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties". J. Biol. Chem. 271 (38): 23277–83. PMID 8798526.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Forissier JF, Carrier L, Farza H; et al. (1997). "Codon 102 of the cardiac troponin T gene is a putative hot spot for mutations in familial hypertrophic cardiomyopathy". Circulation. 94 (12): 3069–73. PMID 8989109.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moolman JC, Corfield VA, Posen B; et al. (1997). "Sudden death due to troponin T mutations". J. Am. Coll. Cardiol. 29 (3): 549–55. PMID 9060892.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakajima-Taniguchi C, Matsui H, Fujio Y; et al. (1997). "Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy". J. Mol. Cell. Cardiol. 29 (2): 839–43. doi:10.1006/jmcc.1996.0322. PMID 9140840.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)