TLX3

T-cell leukemia homeobox 3
Identifiers
Symbols	TLX3 ; HOX11L2; MGC29804; RNX
External IDs	Template:OMIM5 Template:MGI HomoloGene: 23181
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TLX3 208495 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

T-cell leukemia homeobox 3, also known as TLX3, is a human gene.

RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993).[supplied by OMIM]

Further reading

• Dear TN, Sanchez-Garcia I, Rabbitts TH (1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4431–5. PMID 8099440.CS1 maint: Multiple names: authors list (link)
• Cinti R, Fava M, Sancandi M; et al. (2001). "Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization". Cytogenet. Cell Genet. 92 (3–4): 354–5. PMID 11435716.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee-Kirsch MA, Engel K, Paditz E; et al. (2001). "Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34-->q35 by radiation hybrid mapping". Cytogenet. Cell Genet. 92 (3–4): 358. PMID 11435718.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bernard OA, Busson-LeConiat M, Ballerini P; et al. (2002). "A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia". Leukemia. 15 (10): 1495–504. PMID 11587205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ballerini P, Blaise A, Busson-Le Coniat M; et al. (2002). "HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis". Blood. 100 (3): 991–7. doi:10.1182/blood-2001-11-0093. PMID 12130513.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matera I, Bachetti T, Cinti R; et al. (2003). "Mutational analysis of the RNX gene in congenital central hypoventilation syndrome". Am. J. Med. Genet. 113 (2): 178–82. doi:10.1002/ajmg.10746. PMID 12407709.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mauvieux L, Leymarie V, Helias C; et al. (2003). "High incidence of Hox11L2 expression in children with T-ALL". Leukemia. 16 (12): 2417–22. doi:10.1038/sj.leu.2402709. PMID 12454747.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berger R, Dastugue N, Busson M; et al. (2003). "t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH)". Leukemia. 17 (9): 1851–7. doi:10.1038/sj.leu.2403061. PMID 12970786.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cavé H, Suciu S, Preudhomme C; et al. (2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951". Blood. 103 (2): 442–50. doi:10.1182/blood-2003-05-1495. PMID 14504110.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Su XY, Busson M, Della Valle V; et al. (2004). "Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia". Genes Chromosomes Cancer. 41 (3): 243–9. doi:10.1002/gcc.20088. PMID 15334547.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ballerini P, Busson M, Fasola S; et al. (2005). "NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance". Leukemia. 19 (3): 468–70. doi:10.1038/sj.leu.2403654. PMID 15674415.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gottardo NG, Jacoby PA, Sather HN; et al. (2005). "Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols". Leukemia. 19 (9): 1705–8. doi:10.1038/sj.leu.2403834. PMID 15990867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Borghini S, Vargiolu M, Di Duca M; et al. (2006). "Nuclear factor Y drives basal transcription of the human TLX3, a gene overexpressed in T-cell acute lymphocytic leukemia". Mol. Cancer Res. 4 (9): 635–43. doi:10.1158/1541-7786.MCR-05-0250. PMID 16966433.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagel S, Scherr M, Kel A; et al. (2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1". Cancer Res. 67 (4): 1461–71. doi:10.1158/0008-5472.CAN-06-2615. PMID 17308084.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)