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{{Infobox_gene}}
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'''Transducin-like enhancer protein 2''' is a [[protein]] that in humans is encoded by the ''TLE2'' [[gene]].<ref name="pmid8808280">{{cite journal |vauthors=Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S | title = Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia | journal = Genomics | volume = 31 | issue = 1 | pages = 58–64 |date=Oct 1996 | pmid = 8808280 | pmc =  | doi = 10.1006/geno.1996.0009 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7089| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
| HGNCid = 11838
| Symbol = TLE2
| AltSymbols =; ESG; ESG2; FLJ41188; GRG2
| OMIM = 601041
| ECnumber = 
| Homologene = 20693
| MGIid = 104635
| GeneAtlas_image1 = PBB_GE_TLE2_40837_at_tn.png
| GeneAtlas_image2 = PBB_GE_TLE2_204431_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7089
    | Hs_Ensembl = ENSG00000065717
    | Hs_RefseqProtein = NP_003251
    | Hs_RefseqmRNA = NM_003260
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 2948637
    | Hs_GenLoc_end = 2980022
    | Hs_Uniprot = Q04725
    | Mm_EntrezGene = 21886
    | Mm_Ensembl = ENSMUSG00000034771
    | Mm_RefseqmRNA = NM_019725
    | Mm_RefseqProtein = NP_062699
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 80978460
    | Mm_GenLoc_end = 80993974
    | Mm_Uniprot = Q3UN01
  }}
}}
'''Transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)''', also known as '''TLE2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7089| accessdate = }}</ref>


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==Interactions==
TLE2 has been shown to [[Protein-protein interaction|interact]] with [[TLE1]]<ref name=pmid9874198>{{cite journal |last=Grbavec |first=D |authorlink= |author2=Lo R |author3=Liu Y |author4=Stifani S  |date=Dec 1998 |title=Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development |journal=Eur. J. Biochem. |volume=258 |issue=2 |pages=339–49 |publisher= |location = GERMANY| issn = 0014-2956| pmid = 9874198 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1046/j.1432-1327.1998.2580339.x }}</ref> and [[HES1]].<ref name=pmid9874198/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Stifani S, Blaumueller CM, Redhead NJ, ''et al.'' |title=Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. |journal=Nat. Genet. |volume=2 |issue= 2 |pages= 119-27 |year= 1993 |pmid= 1303260 |doi= 10.1038/ng1092-119 }}
*{{cite journal   |vauthors=Stifani S, Blaumueller CM, Redhead NJ, etal |title=Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. |journal=Nat. Genet. |volume=2 |issue= 2 |pages= 119–27 |year= 1993 |pmid= 1303260 |doi= 10.1038/ng1092-119 }}
*{{cite journal  | author=Miyasaka H, Choudhury BK, Hou EW, Li SS |title=Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. |journal=Eur. J. Biochem. |volume=216 |issue= 1 |pages= 343-52 |year= 1993 |pmid= 8365415 |doi= }}
*{{cite journal  |vauthors=Miyasaka H, Choudhury BK, Hou EW, Li SS |title=Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. |journal=Eur. J. Biochem. |volume=216 |issue= 1 |pages= 343–52 |year= 1993 |pmid= 8365415 |doi=10.1111/j.1432-1033.1993.tb18151.x  }}
*{{cite journal  | author=Liu Y, Dehni G, Purcell KJ, ''et al.'' |title=Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. |journal=Genomics |volume=31 |issue= 1 |pages= 58-64 |year= 1996 |pmid= 8808280 |doi= 10.1006/geno.1996.0009 }}
*{{cite journal  |vauthors=Palaparti A, Baratz A, Stifani S |title=The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26604–10 |year= 1997 |pmid= 9334241 |doi=10.1074/jbc.272.42.26604 }}
*{{cite journal  | author=Palaparti A, Baratz A, Stifani S |title=The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26604-10 |year= 1997 |pmid= 9334241 |doi=  }}
*{{cite journal   |vauthors=Grbavec D, Lo R, Liu Y, etal |title=Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms. |journal=Biochem. J. |volume=337 |issue=  1|pages= 13–7 |year= 1999 |pmid= 9854018 |doi=10.1042/0264-6021:3370013  | pmc=1219929 }}
*{{cite journal | author=Grbavec D, Lo R, Liu Y, ''et al.'' |title=Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms. |journal=Biochem. J. |volume=337 ( Pt 1) |issue=  |pages= 13-7 |year= 1999 |pmid= 9854018 |doi=  }}
*{{cite journal  |vauthors=Grbavec D, Lo R, Liu Y, Stifani S |title=Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. |journal=Eur. J. Biochem. |volume=258 |issue= 2 |pages= 339–49 |year= 1999 |pmid= 9874198 |doi=10.1046/j.1432-1327.1998.2580339.x }}
*{{cite journal  | author=Grbavec D, Lo R, Liu Y, Stifani S |title=Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. |journal=Eur. J. Biochem. |volume=258 |issue= 2 |pages= 339-49 |year= 1999 |pmid= 9874198 |doi=  }}
*{{cite journal  |vauthors=Ren B, Chee KJ, Kim TH, Maniatis T |title=PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. |journal=Genes Dev. |volume=13 |issue= 1 |pages= 125–37 |year= 1999 |pmid= 9887105 |doi=10.1101/gad.13.1.125  | pmc=316372 }}
*{{cite journal  | author=Ren B, Chee KJ, Kim TH, Maniatis T |title=PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. |journal=Genes Dev. |volume=13 |issue= 1 |pages= 125-37 |year= 1999 |pmid= 9887105 |doi=  }}
*{{cite journal   |vauthors=Javed A, Guo B, Hiebert S, etal |title=Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. |journal=J. Cell Sci. |volume=113 |issue=  12|pages= 2221–31 |year= 2000 |pmid= 10825294 |doi=  }}
*{{cite journal | author=Javed A, Guo B, Hiebert S, ''et al.'' |title=Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. |journal=J. Cell. Sci. |volume=113 ( Pt 12) |issue=  |pages= 2221-31 |year= 2000 |pmid= 10825294 |doi=  }}
*{{cite journal  |vauthors=Brantjes H, Roose J, van De Wetering M, Clevers H |title=All Tcf HMG box transcription factors interact with Groucho-related co-repressors. |journal=Nucleic Acids Res. |volume=29 |issue= 7 |pages= 1410–9 |year= 2001 |pmid= 11266540 |doi=10.1093/nar/29.7.1410  | pmc=31284 }}
*{{cite journal  | author=Brantjes H, Roose J, van De Wetering M, Clevers H |title=All Tcf HMG box transcription factors interact with Groucho-related co-repressors. |journal=Nucleic Acids Res. |volume=29 |issue= 7 |pages= 1410-9 |year= 2001 |pmid= 11266540 |doi=  }}
*{{cite journal  |vauthors=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021–8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 }}
*{{cite journal  | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021-8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Higa LA, Wu M, Ye T, etal |title=CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. |journal=Nat. Cell Biol. |volume=8 |issue= 11 |pages= 1277–83 |year= 2006 |pmid= 17041588 |doi= 10.1038/ncb1490 }}
*{{cite journal | author=Higa LA, Wu M, Ye T, ''et al.'' |title=CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. |journal=Nat. Cell Biol. |volume=8 |issue= 11 |pages= 1277-83 |year= 2006 |pmid= 17041588 |doi= 10.1038/ncb1490 }}
}}
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{{refend}}
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Latest revision as of 19:13, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transducin-like enhancer protein 2 is a protein that in humans is encoded by the TLE2 gene.[1][2]


Interactions

TLE2 has been shown to interact with TLE1[3] and HES1.[3]

References

  1. ↑ Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Oct 1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics. 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280.
  2. ↑ "Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)".
  3. ↑ 3.0 3.1 Grbavec, D; Lo R; Liu Y; Stifani S (Dec 1998). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development". Eur. J. Biochem. GERMANY. 258 (2): 339–49. doi:10.1046/j.1432-1327.1998.2580339.x. ISSN 0014-2956. PMID 9874198.

Further reading



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