View source for THOC1

{{Infobox_gene}}
'''THO complex subunit 1''' is a [[protein]] that in humans is encoded by the ''THOC1'' [[gene]].<ref name="pmid11979277">{{cite journal |vauthors=Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E | title = TREX is a conserved complex coupling transcription with messenger RNA export | journal = Nature | volume = 417 | issue = 6886 | pages = 304–8 |date=May 2002 | pmid = 11979277 | pmc =  | doi = 10.1038/nature746 | bibcode =2002Natur.417..304S }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: THOC1 THO complex 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9984| accessdate = }}</ref>

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{{PBB_Summary
| section_title =
| summary_text = HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM]<ref name="entrez"/>
}}

==Interactions==
THOC1 has been shown to [[Protein-protein interaction|interact]] with [[Retinoblastoma protein]].<ref name=pmid7525595>{{cite journal |last=Durfee |first=T |authorlink= |author2=Mancini M A |author3=Jones D |author4=Elledge S J |author5=Lee W H  |date=November 1994  |title=The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing |journal=J. Cell Biol. |volume=127 |issue=3 |pages=609–22 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 7525595 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1083/jcb.127.3.609 |pmc=2120229 }}</ref>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
* {{cite journal   |vauthors=Durfee T, Mancini MA, Jones D, etal |title=The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. |journal=J. Cell Biol. |volume=127 |issue= 3 |pages= 609–22 |year= 1994 |pmid= 7525595 |doi=10.1083/jcb.127.3.609  | pmc=2120229  }}
* {{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
* {{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
* {{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
* {{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal  |vauthors=Dennehey BK, Gutches DG, McConkey EH, Krauter KS |title=Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution. |journal=Genomics |volume=83 |issue= 3 |pages= 493–501 |year= 2004 |pmid= 14962675 |doi= 10.1016/j.ygeno.2003.08.017 }}
* {{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 |bibcode=2004PNAS..10112130B }}
* {{cite journal  |vauthors=Gasparri F, Sola F, Locatelli G, Muzio M |title=The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm. |journal=FEBS Lett. |volume=574 |issue= 1–3 |pages= 13–9 |year= 2004 |pmid= 15358532 |doi= 10.1016/j.febslet.2004.07.074 }}
* {{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
* {{cite journal  |vauthors=Li Y, Wang X, Zhang X, Goodrich DW |title=Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. |journal=Mol. Cell. Biol. |volume=25 |issue= 10 |pages= 4023–33 |year= 2005 |pmid= 15870275 |doi= 10.1128/MCB.25.10.4023-4033.2005  | pmc=1087710 }}
* {{cite journal   |vauthors=Masuda S, Das R, Cheng H, etal |title=Recruitment of the human TREX complex to mRNA during splicing. |journal=Genes Dev. |volume=19 |issue= 13 |pages= 1512–7 |year= 2005 |pmid= 15998806 |doi= 10.1101/gad.1302205  | pmc=1172058 }}
* {{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
* {{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
* {{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
* {{cite journal   |vauthors=Li Y, Lin AW, Zhang X, etal |title=Cancer cells and normal cells differ in their requirements for Thoc1. |journal=Cancer Res. |volume=67 |issue= 14 |pages= 6657–64 |year= 2007 |pmid= 17638875 |doi= 10.1158/0008-5472.CAN-06-3234  | pmc=2804983 }}
* {{cite journal   |vauthors=Garner E, Martinon F, Tschopp J, etal |title=Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6. |journal=Cancer Res. |volume=67 |issue= 16 |pages= 7631–7 |year= 2007 |pmid= 17699767 |doi= 10.1158/0008-5472.CAN-07-0334 }}
}}
{{refend}}
{{PDB Gallery|geneid=9984}}

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