TEA consensus sequence gene transcriptions

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Associate Editor(s)-in-Chief: Henry A. Hoff

"The TEA/ATTS transcription factor family consists of mammalian, avian, nematode, insect and fungal members that share a conserved TEA domain. The TEA domain (Bürglin, 1991) represents a DNA‐binding region that is composed of 66–76 conserved amino acids (aa) in the N‐terminal section of the proteins."[1]

Human genes

Gene expressions

Interactions

Consensus sequences

"The TEA consensus sequence (TCS) in a fungal TEA/ATTS transcription factor target promoter has been defined as 5′‐CATTCY‐3′ (Andrianopoulos and Timberlake, 1994)."[1]

Binding site for

Enhancer activity

Promoter occurrences

Hypotheses

  1. A1BG has no regulatory elements in either promoter.
  2. A1BG is not transcribed by a regulatory element.
  3. No regulatory element participates in the transcription of A1BG.

TEA samplings

Copying a responsive elements consensus sequence CATTC(C/T) and putting the sequence in "⌘F" finds three between ZNF497 and A1BG or 2 between ZSCAN22 and A1BG as can be found by the computer programs.

For the Basic programs testing consensus sequence CATTC(C/T) (starting with SuccessablesTEA.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

  1. negative strand, negative direction, looking for CATTC(C/T), 2, CATTCT at 3893, CATTCT at 2503.
  2. positive strand, negative direction, looking for CATTC(C/T), 0.
  3. positive strand, positive direction, looking for CATTC(C/T), 1, CATTCC at 2457.
  4. negative strand, positive direction, looking for CATTC(C/T), 2, CATTCT at 3074, CATTCC at 2208.
  1. inverse complement, negative strand, negative direction, looking for TTTTTTTT, 0.
  2. inverse complement, positive strand, negative direction, looking for (A/G)GAATG, 0.
  3. inverse complement, positive strand, positive direction, looking for TTTTTTTT, 0.
  4. inverse complement, negative strand, positive direction, looking for TTTTTTTT, 0.

TEA UTRs

Negative strand, negative direction: CATTCT at 3893.

TEA core promoters

TEA proximal promoters

TEA distal promoters

Negative strand, negative direction: CATTCT at 2503.

Negative strand, positive direction: CATTCT at 3074, CATTCC at 2208.

Positive strand, positive direction: CATTCC at 2457.

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

See also

References

  1. 1.0 1.1 Anja Schweizer, Steffen Rupp, Brad N. Taylor, Martin Röllinghoff, Klaus Schröppel (November 2000). "The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans". Molecular Microbiology. 38 (3): 435–445. doi:10.1046/j.1365-2958.2000.02132.x. Retrieved 21 April 2021.

External links