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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Transducin (beta)-like 1X-linked''', also known as '''TBL1X''', is a [[protein]] which in humans is encoded by the ''TBL1X'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TBL1X transducin (beta)-like 1X-linked| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6907| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transducin (beta)-like 1X-linked
| HGNCid = 11585
| Symbol = TBL1X
| AltSymbols =; EBI; TBL1
| OMIM = 300196
| ECnumber = 
| Homologene = 4128
| MGIid = 1336172
| GeneAtlas_image1 = PBB_GE_TBL1X_213400_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TBL1X_201867_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TBL1X_201868_s_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6907
    | Hs_Ensembl = ENSG00000101849
    | Hs_RefseqProtein = NP_005638
    | Hs_RefseqmRNA = NM_005647
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 9391369
    | Hs_GenLoc_end = 9647777
    | Hs_Uniprot = O60907
    | Mm_EntrezGene = 21372
    | Mm_Ensembl = ENSMUSG00000025246
    | Mm_RefseqmRNA = NM_020601
    | Mm_RefseqProtein = NP_065626
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 73894169
    | Mm_GenLoc_end = 73911524
    | Mm_Uniprot = Q9QXE7
  }}
}}
'''Transducin (beta)-like 1X-linked''', also known as '''TBL1X''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TBL1X transducin (beta)-like 1X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6907| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene has sequence similarity with members of the [[WD40 repeat]]-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in [[signal transduction]], RNA processing, [[gene regulation]], vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in [[corepressor (genetics)|corepressor]] [[nuclear receptor co-repressor 2|SMRT]] (silencing mediator for retinoid and thyroid receptors) complex along with [[histone deacetylase]] 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the [[ocular albinism]] with late-onset [[sensorineural hearing loss|sensorineural deafness]] phenotype. This gene is highly similar to the Y chromosome TBL1Y gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. This gene is highly similar to the Y chromosome TBL1Y gene.<ref name="entrez">{{cite web | title = Entrez Gene: TBL1X transducin (beta)-like 1X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6907| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
TBL1X has been shown to [[Protein-protein interaction|interact]] with:
* [[GPS2 (gene)|GPS2]],<ref name = pmid11931768/> and
* [[HDAC3]],<ref name = pmid11931768/><ref name = pmid10809664/>
* [[Nuclear receptor co-repressor 1|NCOA1]],<ref name = pmid11931768>{{cite journal | vauthors = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | journal = Mol. Cell | volume = 9 | issue = 3 | pages = 611–23 | date = March 2002 | pmid = 11931768 | doi =  10.1016/s1097-2765(02)00468-9}}</ref><ref name = pmid10809664>{{cite journal | vauthors = Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R | title = A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness | journal = Genes Dev. | volume = 14 | issue = 9 | pages = 1048–57 | date = May 2000 | pmid = 10809664 | pmc = 316569 | doi =  10.1101/gad.14.9.1048| doi-broken-date = 2018-09-05 }}</ref><ref name = pmid12628926>{{cite journal | vauthors = Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J | title = Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 | journal = EMBO J. | volume = 22 | issue = 6 | pages = 1336–46 | date = March 2003 | pmid = 12628926 | pmc = 151047 | doi = 10.1093/emboj/cdg120 }}</ref><ref name = pmid10944117>{{cite journal | vauthors = Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J | title = Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 | journal = EMBO J. | volume = 19 | issue = 16 | pages = 4342–50 | date = August 2000 | pmid = 10944117 | pmc = 302030 | doi = 10.1093/emboj/19.16.4342 }}</ref>  and
* [[Nuclear receptor co-repressor 2|NCOA2]].<ref name = pmid10809664/><ref name = pmid12628926/><ref name = pmid10944117/><ref name = pmid12502735>{{cite journal | vauthors = Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA | title = Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex | journal = Genes Dev. | volume = 16 | issue = 24 | pages = 3130–5 | date = December 2002 | pmid = 12502735 | pmc = 187500 | doi = 10.1101/gad.1037502 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bassi MT, Ramesar RS, Caciotti B, Winship IM, De Grandi A, Riboni M, Townes PL, Beighton P, Ballabio A, Borsani G | title = X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats | journal = Am. J. Hum. Genet. | volume = 64 | issue = 6 | pages = 1604–16 | year = 1999 | pmid = 10330347 | pmc = 1377903 | doi = 10.1086/302408 }}
| citations =
* {{cite journal | vauthors = Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R | title = A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness | journal = Genes Dev. | volume = 14 | issue = 9 | pages = 1048–57 | year = 2000 | pmid = 10809664 | pmc = 316569 | doi =  10.1101/gad.14.9.1048| doi-broken-date = 2018-09-05 }}
*{{cite journal | author=Bassi MT, Ramesar RS, Caciotti B, ''et al.'' |title=X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats. |journal=Am. J. Hum. Genet. |volume=64 |issue= 6 |pages= 1604-16 |year= 1999 |pmid= 10330347 |doi= }}
* {{cite journal | vauthors = Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J | title = Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 | journal = EMBO J. | volume = 19 | issue = 16 | pages = 4342–50 | year = 2000 | pmid = 10944117 | pmc = 302030 | doi = 10.1093/emboj/19.16.4342 }}
*{{cite journal | author=Guenther MG, Lane WS, Fischle W, ''et al.'' |title=A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. |journal=Genes Dev. |volume=14 |issue= 9 |pages= 1048-57 |year= 2000 |pmid= 10809664 |doi=  }}
* {{cite journal | vauthors = Matsuzawa SI, Reed JC | title = Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses | journal = Mol. Cell | volume = 7 | issue = 5 | pages = 915–26 | year = 2001 | pmid = 11389839 | doi = 10.1016/S1097-2765(01)00242-8 }}
*{{cite journal | author=Li J, Wang J, Wang J, ''et al.'' |title=Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. |journal=EMBO J. |volume=19 |issue= 16 |pages= 4342-50 |year= 2000 |pmid= 10944117 |doi= 10.1093/emboj/19.16.4342 }}
* {{cite journal | vauthors = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | journal = Mol. Cell | volume = 9 | issue = 3 | pages = 611–23 | year = 2002 | pmid = 11931768 | doi = 10.1016/S1097-2765(02)00468-9 }}
*{{cite journal | author=Matsuzawa SI, Reed JC |title=Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. |journal=Mol. Cell |volume=7 |issue= 5 |pages= 915-26 |year= 2001 |pmid= 11389839 |doi= }}
* {{cite journal | vauthors = Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J | title = Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 | journal = EMBO J. | volume = 22 | issue = 6 | pages = 1336–46 | year = 2003 | pmid = 12628926 | pmc = 151047 | doi = 10.1093/emboj/cdg120 }}
*{{cite journal | author=Zhang J, Kalkum M, Chait BT, Roeder RG |title=The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. |journal=Mol. Cell |volume=9 |issue= 3 |pages= 611-23 |year= 2002 |pmid= 11931768 |doi= }}
* {{cite journal | vauthors = Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J | title = N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso | journal = Mol. Cell | volume = 12 | issue = 3 | pages = 723–34 | year = 2003 | pmid = 14527417 | doi = 10.1016/j.molcel.2003.08.008 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG | title = A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors | journal = Cell | volume = 116 | issue = 4 | pages = 511–26 | year = 2004 | pmid = 14980219 | doi = 10.1016/S0092-8674(04)00133-3 }}
*{{cite journal | author=Yoon HG, Chan DW, Huang ZQ, ''et al.'' |title=Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. |journal=EMBO J. |volume=22 |issue= 6 |pages= 1336-46 |year= 2003 |pmid= 12628926 |doi= 10.1093/emboj/cdg120 }}
* {{cite journal | vauthors = Yoon HG, Choi Y, Cole PA, Wong J | title = Reading and function of a histone code involved in targeting corepressor complexes for repression | journal = Mol. Cell. Biol. | volume = 25 | issue = 1 | pages = 324–35 | year = 2005 | pmid = 15601853 | pmc = 538779 | doi = 10.1128/MCB.25.1.324-335.2005 }}
*{{cite journal | author=Yoon HG, Chan DW, Reynolds AB, ''et al.'' |title=N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 723-34 |year= 2003 |pmid= 14527417 |doi= }}
* {{cite journal | vauthors = Gerlitz G, Darhin E, Giorgio G, Franco B, Reiner O | title = Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization | journal = Cell Cycle | volume = 4 | issue = 11 | pages = 1632–40 | year = 2005 | pmid = 16258276 | doi = 10.4161/cc.4.11.2151 }}
*{{cite journal | author=Perissi V, Aggarwal A, Glass CK, ''et al.'' |title=A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. |journal=Cell |volume=116 |issue= 4 |pages= 511-26 |year= 2004 |pmid= 14980219 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Yoon HG, Choi Y, Cole PA, Wong J |title=Reading and function of a histone code involved in targeting corepressor complexes for repression. |journal=Mol. Cell. Biol. |volume=25 |issue= 1 |pages= 324-35 |year= 2005 |pmid= 15601853 |doi= 10.1128/MCB.25.1.324-335.2005 }}
*{{cite journal | author=Gerlitz G, Darhin E, Giorgio G, ''et al.'' |title=Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization. |journal=Cell Cycle |volume=4 |issue= 11 |pages= 1632-40 |year= 2007 |pmid= 16258276 |doi= }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-X-stub}}

Latest revision as of 22:52, 5 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transducin (beta)-like 1X-linked, also known as TBL1X, is a protein which in humans is encoded by the TBL1X gene.[1]

Function

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. This gene is highly similar to the Y chromosome TBL1Y gene.[1]

Interactions

TBL1X has been shown to interact with:

References

  1. ↑ 1.0 1.1 "Entrez Gene: TBL1X transducin (beta)-like 1X-linked".
  2. ↑ 2.0 2.1 2.2 Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell. 9 (3): 611–23. doi:10.1016/s1097-2765(02)00468-9. PMID 11931768.
  3. ↑ 3.0 3.1 3.2 Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (May 2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes Dev. 14 (9): 1048–57. doi:10.1101/gad.14.9.1048 (inactive 2018-09-05). PMC 316569. PMID 10809664.
  4. ↑ 4.0 4.1 Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (March 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
  5. ↑ 5.0 5.1 Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (August 2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". EMBO J. 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. PMC 302030. PMID 10944117.
  6. ↑ Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA (December 2002). "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex". Genes Dev. 16 (24): 3130–5. doi:10.1101/gad.1037502. PMC 187500. PMID 12502735.

Further reading


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