TARBP2

Tar (HIV-1) RNA binding protein 2
File:PBB Protein TARBP2 image.jpg PDB rendering based on 2cpn.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2cpn​
Identifiers
Symbols	TARBP2 ; TRBP; TRBP1; TRBP2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7562
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE TARBP2 203677 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tar (HIV-1) RNA binding protein 2, also known as TARBP2, is a human gene.

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.

Further reading

• Gatignol A, Buckler-White A, Berkhout B, Jeang KT (1991). "Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR". Science. 251 (5001): 1597–600. PMID 2011739.CS1 maint: Multiple names: authors list (link)
• Cosentino GP, Venkatesan S, Serluca FC; et al. (1995). "Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9445–9. PMID 7568151.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kozak CA, Gatignol A, Graham K; et al. (1995). "Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1)". Genomics. 25 (1): 66–72. PMID 7774957.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gatignol A, Buckler C, Jeang KT (1993). "Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen". Mol. Cell. Biol. 13 (4): 2193–202. PMID 8455607.CS1 maint: Multiple names: authors list (link)
• Gatignol A, Duarte M, Daviet L; et al. (1996). "Sequential steps in Tat trans-activation of HIV-1 mediated through cellular DNA, RNA, and protein binding factors". Gene Expr. 5 (4–5): 217–28. PMID 8723388.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kasof GM, Goyal L, White E (1999). "Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins". Mol. Cell. Biol. 19 (6): 4390–404. PMID 10330179.CS1 maint: Multiple names: authors list (link)
• Daviet L, Erard M, Dorin D; et al. (2000). "Analysis of a binding difference between the two dsRNA-binding domains in TRBP reveals the modular function of a KR-helix motif". Eur. J. Biochem. 267 (8): 2419–31. PMID 10759868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duarte M, Graham K, Daher A; et al. (2001). "Characterization of TRBP1 and TRBP2. Stable stem-loop structure at the 5' end of TRBP2 mRNA resembles HIV-1 TAR and is not found in its processed pseudogene". J. Biomed. Sci. 7 (6): 494–506. PMID 11060498.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Siffroi JP, Pawlak A, Alfonsi MF; et al. (2001). "Expression of the TAR RNA binding protein in human testis". Mol. Hum. Reprod. 7 (3): 219–25. PMID 11228241.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Daher A, Longuet M, Dorin D; et al. (2001). "Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression". J. Biol. Chem. 276 (36): 33899–905. doi:10.1074/jbc.M103584200. PMID 11438532.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iwasaki T, Chin WW, Ko L (2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.CS1 maint: Multiple names: authors list (link)
• Bannwarth S, Talakoub L, Letourneur F; et al. (2002). "Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line". J. Biol. Chem. 276 (52): 48803–13. doi:10.1074/jbc.M104645200. PMID 11641396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu YC, Wu RF, Gu Y; et al. (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase". J. Biol. Chem. 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Battisti PL, Daher A, Bannwarth S; et al. (2003). "Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells". AIDS Res. Hum. Retroviruses. 19 (9): 767–78. doi:10.1089/088922203769232566. PMID 14585207.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee JY, Kim H, Ryu CH; et al. (2004). "Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity". J. Biol. Chem. 279 (29): 30265–73. doi:10.1074/jbc.M312083200. PMID 15123692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haase AD, Jaskiewicz L, Zhang H; et al. (2006). "TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing". EMBO Rep. 6 (10): 961–7. doi:10.1038/sj.embor.7400509. PMID 16142218.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bannwarth S, Lainé S, Daher A; et al. (2006). "Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes". J. Mol. Biol. 355 (5): 898–910. doi:10.1016/j.jmb.2005.11.026. PMID 16343534.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Christensen HS, Daher A, Soye KJ; et al. (2007). "Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production". J. Virol. 81 (10): 5121–31. doi:10.1128/JVI.01511-06. PMID 17360756.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)