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{{Infobox_gene}}
{{PBB_Controls
'''RISC-loading complex subunit TARBP2''' is a [[protein]] that in humans is encoded by the ''TARBP2'' [[gene]].<ref name="pmid2011739">{{cite journal | vauthors = Gatignol A, Buckler-White A, Berkhout B, Jeang KT | title = Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR | journal = Science | volume = 251 | issue = 5001 | pages = 1597–600 | date = Mar 1991 | pmid = 2011739 | pmc =  | doi = 10.1126/science.2011739 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TARBP2 Tar (HIV-1) RNA binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6895| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_TARBP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cpn.
| PDB = {{PDB2|2cpn}}
| Name = Tar (HIV-1) RNA binding protein 2
| HGNCid = 11569
| Symbol = TARBP2
| AltSymbols =; TRBP; TRBP1; TRBP2
| OMIM = 605053
| ECnumber = 
| Homologene = 7562
| MGIid = 103027
| GeneAtlas_image1 = PBB_GE_TARBP2_203677_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003725 |text = double-stranded RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6895
    | Hs_Ensembl = ENSG00000139546
    | Hs_RefseqProtein = NP_004169
    | Hs_RefseqmRNA = NM_004178
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 52180972
    | Hs_GenLoc_end = 52186480
    | Hs_Uniprot = Q15633
    | Mm_EntrezGene = 21357
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_009319
    | Mm_RefseqProtein = NP_033345
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Tar (HIV-1) RNA binding protein 2''', also known as '''TARBP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TARBP2 Tar (HIV-1) RNA binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6895| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[HIV-1]], the causative agent of [[acquired immunodeficiency syndrome]] (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a [[pseudogene]].<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.<ref name="entrez">{{cite web | title = Entrez Gene: TARBP2 Tar (HIV-1) RNA binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6895| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Gatignol A, Buckler-White A, Berkhout B, Jeang KT |title=Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. |journal=Science |volume=251 |issue= 5001 |pages= 1597-600 |year= 1991 |pmid= 2011739 |doi=  }}
*{{cite journal  | author=Cosentino GP, Venkatesan S, Serluca FC, ''et al.'' |title=Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9445-9 |year= 1995 |pmid= 7568151 |doi=  }}
*{{cite journal  | author=Kozak CA, Gatignol A, Graham K, ''et al.'' |title=Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1). |journal=Genomics |volume=25 |issue= 1 |pages= 66-72 |year= 1995 |pmid= 7774957 |doi=  }}
*{{cite journal  | author=Gatignol A, Buckler C, Jeang KT |title=Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen. |journal=Mol. Cell. Biol. |volume=13 |issue= 4 |pages= 2193-202 |year= 1993 |pmid= 8455607 |doi=  }}
*{{cite journal  | author=Gatignol A, Duarte M, Daviet L, ''et al.'' |title=Sequential steps in Tat trans-activation of HIV-1 mediated through cellular DNA, RNA, and protein binding factors. |journal=Gene Expr. |volume=5 |issue= 4-5 |pages= 217-28 |year= 1996 |pmid= 8723388 |doi=  }}
*{{cite journal  | author=Kasof GM, Goyal L, White E |title=Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4390-404 |year= 1999 |pmid= 10330179 |doi=  }}
*{{cite journal  | author=Daviet L, Erard M, Dorin D, ''et al.'' |title=Analysis of a binding difference between the two dsRNA-binding domains in TRBP reveals the modular function of a KR-helix motif. |journal=Eur. J. Biochem. |volume=267 |issue= 8 |pages= 2419-31 |year= 2000 |pmid= 10759868 |doi=  }}
*{{cite journal  | author=Duarte M, Graham K, Daher A, ''et al.'' |title=Characterization of TRBP1 and TRBP2. Stable stem-loop structure at the 5' end of TRBP2 mRNA resembles HIV-1 TAR and is not found in its processed pseudogene. |journal=J. Biomed. Sci. |volume=7 |issue= 6 |pages= 494-506 |year= 2001 |pmid= 11060498 |doi=  }}
*{{cite journal  | author=Siffroi JP, Pawlak A, Alfonsi MF, ''et al.'' |title=Expression of the TAR RNA binding protein in human testis. |journal=Mol. Hum. Reprod. |volume=7 |issue= 3 |pages= 219-25 |year= 2001 |pmid= 11228241 |doi=  }}
*{{cite journal  | author=Daher A, Longuet M, Dorin D, ''et al.'' |title=Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33899-905 |year= 2001 |pmid= 11438532 |doi= 10.1074/jbc.M103584200 }}
*{{cite journal  | author=Iwasaki T, Chin WW, Ko L |title=Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33375-83 |year= 2001 |pmid= 11443112 |doi= 10.1074/jbc.M101517200 }}
*{{cite journal  | author=Bannwarth S, Talakoub L, Letourneur F, ''et al.'' |title=Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line. |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 48803-13 |year= 2002 |pmid= 11641396 |doi= 10.1074/jbc.M104645200 }}
*{{cite journal  | author=Xu YC, Wu RF, Gu Y, ''et al.'' |title=Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28051-7 |year= 2002 |pmid= 12023963 |doi= 10.1074/jbc.M202665200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Battisti PL, Daher A, Bannwarth S, ''et al.'' |title=Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells. |journal=AIDS Res. Hum. Retroviruses |volume=19 |issue= 9 |pages= 767-78 |year= 2003 |pmid= 14585207 |doi= 10.1089/088922203769232566 }}
*{{cite journal  | author=Lee JY, Kim H, Ryu CH, ''et al.'' |title=Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity. |journal=J. Biol. Chem. |volume=279 |issue= 29 |pages= 30265-73 |year= 2004 |pmid= 15123692 |doi= 10.1074/jbc.M312083200 }}
*{{cite journal  | author=Haase AD, Jaskiewicz L, Zhang H, ''et al.'' |title=TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. |journal=EMBO Rep. |volume=6 |issue= 10 |pages= 961-7 |year= 2006 |pmid= 16142218 |doi= 10.1038/sj.embor.7400509 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Bannwarth S, Lainé S, Daher A, ''et al.'' |title=Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes. |journal=J. Mol. Biol. |volume=355 |issue= 5 |pages= 898-910 |year= 2006 |pmid= 16343534 |doi= 10.1016/j.jmb.2005.11.026 }}
*{{cite journal  | author=Christensen HS, Daher A, Soye KJ, ''et al.'' |title=Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production. |journal=J. Virol. |volume=81 |issue= 10 |pages= 5121-31 |year= 2007 |pmid= 17360756 |doi= 10.1128/JVI.01511-06 }}
}}
{{refend}}


{{protein-stub}}
TARBP2 has been shown to [[Protein-protein interaction|interact]] with [[Protein kinase R]]<ref name=pmid7568151>{{cite journal | vauthors = Cosentino GP, Venkatesan S, Serluca FC, Green SR, Mathews MB, Sonenberg N | title = Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 21 | pages = 9445–9 | date = Oct 1995 | pmid = 7568151 | pmc = 40818 | doi = 10.1073/pnas.92.21.9445 }}</ref><ref name=pmid11438532>{{cite journal | vauthors = Daher A, Longuet M, Dorin D, Bois F, Segeral E, Bannwarth S, Battisti PL, Purcell DF, Benarous R, Vaquero C, Meurs EF, Gatignol A | title = Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression | journal = The Journal of Biological Chemistry | volume = 276 | issue = 36 | pages = 33899–905 | date = Sep 2001 | pmid = 11438532 | doi = 10.1074/jbc.M103584200 }}</ref> and [[RBM14]].<ref name=pmid11443112>{{cite journal | vauthors = Iwasaki T, Chin WW, Ko L | title = Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM) | journal = The Journal of Biological Chemistry | volume = 276 | issue = 36 | pages = 33375–83 | date = Sep 2001 | pmid = 11443112 | doi = 10.1074/jbc.M101517200 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Cosentino GP, Venkatesan S, Serluca FC, Green SR, Mathews MB, Sonenberg N | title = Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 21 | pages = 9445–9 | date = Oct 1995 | pmid = 7568151 | pmc = 40818 | doi = 10.1073/pnas.92.21.9445 }}
* {{cite journal | vauthors = Kozak CA, Gatignol A, Graham K, Jeang KT, McBride OW | title = Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1) | journal = Genomics | volume = 25 | issue = 1 | pages = 66–72 | date = Jan 1995 | pmid = 7774957 | doi = 10.1016/0888-7543(95)80110-8 }}
* {{cite journal | vauthors = Gatignol A, Buckler C, Jeang KT | title = Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen | journal = Molecular and Cellular Biology | volume = 13 | issue = 4 | pages = 2193–202 | date = Apr 1993 | pmid = 8455607 | pmc = 359540 | doi =  10.1128/mcb.13.4.2193}}
* {{cite journal | vauthors = Gatignol A, Duarte M, Daviet L, Chang YN, Jeang KT | title = Sequential steps in Tat trans-activation of HIV-1 mediated through cellular DNA, RNA, and protein binding factors | journal = Gene Expression | volume = 5 | issue = 4-5 | pages = 217–28 | year = 1996 | pmid = 8723388 | doi =  }}
* {{cite journal | vauthors = Kasof GM, Goyal L, White E | title = Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 6 | pages = 4390–404 | date = Jun 1999 | pmid = 10330179 | pmc = 104398 | doi =  10.1128/mcb.19.6.4390}}
* {{cite journal | vauthors = Daviet L, Erard M, Dorin D, Duarte M, Vaquero C, Gatignol A | title = Analysis of a binding difference between the two dsRNA-binding domains in TRBP reveals the modular function of a KR-helix motif | journal = European Journal of Biochemistry / FEBS | volume = 267 | issue = 8 | pages = 2419–31 | date = Apr 2000 | pmid = 10759868 | doi = 10.1046/j.1432-1327.2000.01256.x }}
* {{cite journal | vauthors = Duarte M, Graham K, Daher A, Battisti PL, Bannwarth S, Segeral E, Jeang KT, Gatignol A | title = Characterization of TRBP1 and TRBP2. Stable stem-loop structure at the 5' end of TRBP2 mRNA resembles HIV-1 TAR and is not found in its processed pseudogene | journal = Journal of Biomedical Science | volume = 7 | issue = 6 | pages = 494–506 | year = 2001 | pmid = 11060498 | doi = 10.1007/bf02253365 }}
* {{cite journal | vauthors = Siffroi JP, Pawlak A, Alfonsi MF, Troalen F, Guellaen G, Dadoune JP | title = Expression of the TAR RNA binding protein in human testis | journal = Molecular Human Reproduction | volume = 7 | issue = 3 | pages = 219–25 | date = Mar 2001 | pmid = 11228241 | doi = 10.1093/molehr/7.3.219 }}
* {{cite journal | vauthors = Daher A, Longuet M, Dorin D, Bois F, Segeral E, Bannwarth S, Battisti PL, Purcell DF, Benarous R, Vaquero C, Meurs EF, Gatignol A | title = Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression | journal = The Journal of Biological Chemistry | volume = 276 | issue = 36 | pages = 33899–905 | date = Sep 2001 | pmid = 11438532 | doi = 10.1074/jbc.M103584200 }}
* {{cite journal | vauthors = Iwasaki T, Chin WW, Ko L | title = Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM) | journal = The Journal of Biological Chemistry | volume = 276 | issue = 36 | pages = 33375–83 | date = Sep 2001 | pmid = 11443112 | doi = 10.1074/jbc.M101517200 }}
* {{cite journal | vauthors = Bannwarth S, Talakoub L, Letourneur F, Duarte M, Purcell DF, Hiscott J, Gatignol A | title = Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line | journal = The Journal of Biological Chemistry | volume = 276 | issue = 52 | pages = 48803–13 | date = Dec 2001 | pmid = 11641396 | doi = 10.1074/jbc.M104645200 }}
* {{cite journal | vauthors = Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS | title = Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 28051–7 | date = Aug 2002 | pmid = 12023963 | doi = 10.1074/jbc.M202665200 }}
* {{cite journal | vauthors = Battisti PL, Daher A, Bannwarth S, Voortman J, Peden KW, Hiscott J, Mouland AJ, Benarous R, Gatignol A | title = Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells | journal = AIDS Research and Human Retroviruses | volume = 19 | issue = 9 | pages = 767–78 | date = Sep 2003 | pmid = 14585207 | doi = 10.1089/088922203769232566 }}
* {{cite journal | vauthors = Lee JY, Kim H, Ryu CH, Kim JY, Choi BH, Lim Y, Huh PW, Kim YH, Lee KH, Jun TY, Rha HK, Kang JK, Choi CR | title = Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity | journal = The Journal of Biological Chemistry | volume = 279 | issue = 29 | pages = 30265–73 | date = Jul 2004 | pmid = 15123692 | doi = 10.1074/jbc.M312083200 }}
* {{cite journal | vauthors = Haase AD, Jaskiewicz L, Zhang H, Lainé S, Sack R, Gatignol A, Filipowicz W | title = TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing | journal = EMBO Reports | volume = 6 | issue = 10 | pages = 961–7 | date = Oct 2005 | pmid = 16142218 | pmc = 1369185 | doi = 10.1038/sj.embor.7400509 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Bannwarth S, Lainé S, Daher A, Grandvaux N, Clerzius G, Leblanc AC, Hiscott J, Gatignol A | title = Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes | journal = Journal of Molecular Biology | volume = 355 | issue = 5 | pages = 898–910 | date = Feb 2006 | pmid = 16343534 | doi = 10.1016/j.jmb.2005.11.026 }}
* {{cite journal | vauthors = Christensen HS, Daher A, Soye KJ, Frankel LB, Alexander MR, Lainé S, Bannwarth S, Ong CL, Chung SW, Campbell SM, Purcell DF, Gatignol A | title = Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production | journal = Journal of Virology | volume = 81 | issue = 10 | pages = 5121–31 | date = May 2007 | pmid = 17360756 | pmc = 1900231 | doi = 10.1128/JVI.01511-06 }}
{{Refend}}
 
{{PDB Gallery|geneid=6895}}
 
{{Gene-12-stub}}

Latest revision as of 11:34, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

RISC-loading complex subunit TARBP2 is a protein that in humans is encoded by the TARBP2 gene.[1][2]

Function

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.[2]

Interactions

TARBP2 has been shown to interact with Protein kinase R[3][4] and RBM14.[5]

References

  1. ↑ Gatignol A, Buckler-White A, Berkhout B, Jeang KT (Mar 1991). "Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR". Science. 251 (5001): 1597–600. doi:10.1126/science.2011739. PMID 2011739.
  2. ↑ 2.0 2.1 "Entrez Gene: TARBP2 Tar (HIV-1) RNA binding protein 2".
  3. ↑ Cosentino GP, Venkatesan S, Serluca FC, Green SR, Mathews MB, Sonenberg N (Oct 1995). "Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo". Proceedings of the National Academy of Sciences of the United States of America. 92 (21): 9445–9. doi:10.1073/pnas.92.21.9445. PMC 40818. PMID 7568151.
  4. ↑ Daher A, Longuet M, Dorin D, Bois F, Segeral E, Bannwarth S, Battisti PL, Purcell DF, Benarous R, Vaquero C, Meurs EF, Gatignol A (Sep 2001). "Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression". The Journal of Biological Chemistry. 276 (36): 33899–905. doi:10.1074/jbc.M103584200. PMID 11438532.
  5. ↑ Iwasaki T, Chin WW, Ko L (Sep 2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". The Journal of Biological Chemistry. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=TARBP2&oldid=1415776"