T-cell large granular lymphocyte leukemia laboratory findings
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Laboratory Findings
- Complete blood count and differential count - neutropenia, anemia, lymphocytosis (in the range of 2-20x109/L)
- Immunoglobulin derangements including hypergammaglobulinemia, autoantibodies, and circulating immune complexes are commonly seen.[1][2][3]
Immunophenotype
The neoplastic cells of this disease display a mature T-cell immunophenotype, with the majority of cases showing a CD4-/CD8+ T-cell subset immunophenotype versus other permutations of those markers. Variable expression of CD11b, CD56, and CD57 are observed. Immunohistochemisty for perforin, TIA-1, and granzyme B are usually positive.
| Type | Immunophenotype |
|---|---|
| Common type (80% of cases) | CD3+, TCRαβ+, CD4-, CD8+ |
| Rare variants | CD3+, TCRαβ+, CD4+, CD8- |
| CD3+, TCRαβ+, CD4+, CD8+ | |
| CD3+, TCRγδ+, CD4 and CD8 variable |
References
- ↑ Oshimi K, Yamada O, Kaneko T; et al. (1993). "Laboratory findings and clinical courses of 33 patients with granular lymphocyte-proliferative disorders". Leukemia. 7 (6): 782–8. PMID 8388971. Unknown parameter
|month=ignored (help) - ↑ Loughran TP, Starkebaum G, Aprile JA (1988). "Rearrangement and expression of T-cell receptor genes in large granular lymphocyte leukemia". Blood. 71 (3): 822–4. PMID 3345349. Unknown parameter
|month=ignored (help) - ↑ Loughran TP, Kadin ME, Starkebaum G; et al. (1985). "Leukemia of large granular lymphocytes: association with clonal chromosomal abnormalities and autoimmune neutropenia, thrombocytopenia, and hemolytic anemia". Ann. Intern. Med. 102 (2): 169–75. PMID 3966754. Unknown parameter
|month=ignored (help)