Suppressor of cytokine signaling 1: Difference between revisions

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{{Infobox_gene}}
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'''Suppressor of cytokine signaling 1''' is a [[protein]] that in humans is encoded by the ''SOCS1'' [[gene]].<ref name="pmid7796808">{{cite journal |vauthors=Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A | title = A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors | journal = EMBO J | volume = 14 | issue = 12 | pages = 2816–26 | date = August 1995 | pmid = 7796808 | pmc = 398400 | doi = }}</ref><ref name="pmid9266833">{{cite journal |vauthors=Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T | title = Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3 | journal = Biochem Biophys Res Commun | volume = 237 | issue = 1 | pages = 79–83 | date = September 1997 | pmid = 9266833 | pmc = | doi = 10.1006/bbrc.1997.7080 }}</ref> ''SOCS1'' [[orthologs]] <ref name="OrthoMaM">{{cite web | title = OrthoMaM phylogenetic marker: SOCS1 coding sequence | url = http://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000185338_SOCS1.xml }}</ref> have been identified in several [[mammals]] for which complete genome data are available.
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| image = 
| image_source = 
| PDB =
| Name = Suppressor of cytokine signaling 1
| HGNCid = 19383
| Symbol = SOCS1
| AltSymbols =; CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3
| OMIM = 603597
| ECnumber = 
| Homologene = 2776
| MGIid = 1354910
| GeneAtlas_image1 = PBB_GE_SOCS1_210001_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SOCS1_209999_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004860 |text = protein kinase inhibitor activity}} {{GNF_GO|id=GO:0005159 |text = insulin-like growth factor receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}  
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0001932 |text = regulation of protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0042518 |text = negative regulation of tyrosine phosphorylation of Stat3 protein}} {{GNF_GO|id=GO:0045444 |text = fat cell differentiation}} {{GNF_GO|id=GO:0046426 |text = negative regulation of JAK-STAT cascade}} {{GNF_GO|id=GO:0046627 |text = negative regulation of insulin receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8651
    | Hs_Ensembl = ENSG00000185338
    | Hs_RefseqProtein = NP_003736
    | Hs_RefseqmRNA = NM_003745
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 11255775
    | Hs_GenLoc_end = 11257540
    | Hs_Uniprot = O15524
    | Mm_EntrezGene = 12703
    | Mm_Ensembl = ENSMUSG00000038037
    | Mm_RefseqmRNA = NM_009896
    | Mm_RefseqProtein = NP_034026
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 10695821
    | Mm_GenLoc_end = 10699114
    | Mm_Uniprot = O35716
  }}
}}
'''Suppressor of cytokine signaling 1''', also known as '''SOCS1''', is a human [[gene]].


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| section_title =
| summary_text = This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.<ref name="entrez">{{cite web | title = Entrez Gene: SOCS1 suppressor of cytokine signaling 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8651| accessdate = }}</ref>
| summary_text = This gene encodes a member of the [[STAT protein|STAT]]-induced STAT inhibitor (SSI), also known as [[suppressor of cytokine signalling]] (SOCS), family. SSI family members are cytokine-inducible negative regulators of [[cytokine]] signaling. The expression of this gene can be induced by a subset of cytokines, including [[Interleukin 2|IL2]], [[Interleukin 3|IL3]] [[erythropoietin]] (EPO), [[Granulocyte macrophage colony-stimulating factor|GM-CSF]], and [[interferon-gamma]] (IFN-γ). The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival.<ref name="entrez">{{cite web | title = Entrez Gene: SOCS1 suppressor of cytokine signaling 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8651| accessdate = }}</ref>
}}
}}
==Interactions==
Suppressor of cytokine signaling 1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[CD117]],<ref name = pmid10022833>{{cite journal |vauthors=De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R | title = Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation | journal = EMBO J. | volume = 18 | issue = 4 | pages = 904–15 | date = February 1999 | pmid = 10022833 | pmc = 1171183 | doi = 10.1093/emboj/18.4.904 }}</ref>
* [[Colony stimulating factor 1 receptor]]<ref name = pmid11297560>{{cite journal |vauthors=Bourette RP, De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G | title = Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal | journal = J. Biol. Chem. | volume = 276 | issue = 25 | pages = 22133–9 | date = June 2001 | pmid = 11297560 | doi = 10.1074/jbc.M101878200 }}</ref>
* [[Growth hormone receptor]],<ref name = pmid10585430>{{cite journal |vauthors=Ram PA, Waxman DJ | title = SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms | journal = J. Biol. Chem. | volume = 274 | issue = 50 | pages = 35553–61 | date = Dec 1999 | pmid = 10585430 | doi =  10.1074/jbc.274.50.35553}}</ref>
* [[IRS2]],<ref name = pmid12228220>{{cite journal |vauthors=Rui L, Yuan M, Frantz D, Shoelson S, White MF | title = SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2 | journal = J. Biol. Chem. | volume = 277 | issue = 44 | pages = 42394–8 | date = November 2002 | pmid = 12228220 | doi = 10.1074/jbc.C200444200 }}</ref>
* [[Janus kinase 2]],<ref name = pmid10064597>{{cite journal |vauthors=Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A | title = The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop | journal = EMBO J. | volume = 18 | issue = 5 | pages = 1309–20 | date = March 1999 | pmid = 10064597 | pmc = 1171221 | doi = 10.1093/emboj/18.5.1309 }}</ref><ref name = pmid11713228>{{cite journal |vauthors=Dif F, Saunier E, Demeneix B, Kelly PA, Edery M | title = Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor | journal = Endocrinology | volume = 142 | issue = 12 | pages = 5286–93 | date = Dec 2001 | pmid = 11713228 | doi = 10.1210/endo.142.12.8549 }}</ref><ref name = pmid9202126>{{cite journal |vauthors=Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A | title = A new protein containing an SH2 domain that inhibits JAK kinases | journal = Nature | volume = 387 | issue = 6636 | pages = 921–4 | date = June 1997 | pmid = 9202126 | doi = 10.1038/43213 }}</ref><ref name = pmid10455112>{{cite journal |vauthors=Pezet A, Favre H, Kelly PA, Edery M | title = Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling | journal = J. Biol. Chem. | volume = 274 | issue = 35 | pages = 24497–502 | date = August 1999 | pmid = 10455112 | doi =  10.1074/jbc.274.35.24497}}</ref><ref name = pmid11971965>{{cite journal |vauthors=Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O | title = Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1 | journal = Mol. Cell. Biol. | volume = 22 | issue = 10 | pages = 3316–26 | date = May 2002 | pmid = 11971965 | pmc = 133778 | doi =  10.1128/mcb.22.10.3316-3326.2002}}</ref><ref name = pmid9344848>{{cite journal |vauthors=Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A | title = Cloning and characterization of novel CIS family genes | journal = Biochem. Biophys. Res. Commun. | volume = 239 | issue = 2 | pages = 439–46 | date = October 1997 | pmid = 9344848 | doi = 10.1006/bbrc.1997.7484 }}</ref>  and
* [[TEC (gene)|TEC]].<ref name = pmid9341160>{{cite journal |author1=Ohya Ki |author2=Kajigaya S |author3=Yamashita Y |author4=Miyazato A |author5=Hatake K |author6=Miura Y |author7=Ikeda U |author8=Shimada K |author9=Ozawa K |author10=Mano H | title = SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase | journal = J. Biol. Chem. | volume = 272 | issue = 43 | pages = 27178–82 | date = October 1997 | pmid = 9341160 | doi =  10.1074/jbc.272.43.27178}}</ref>
{{Div col end}}
{{Clear}}
==See also==
==See also==
*[[SOCS]]
*[[SOCS]]
*[[JAK-STAT signaling pathway]]
*[[JAK-STAT signaling pathway]]
==References==
{{Reflist|35em}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin|35em}}
{{PBB_Further_reading
*{{cite journal |vauthors=Krebs DL, Hilton DJ | title = SOCS proteins: negative regulators of cytokine signaling | journal = Stem Cells | volume = 19 | issue = 5 | pages = 378–87 | year = 2001 | pmid = 11553846 | doi = 10.1634/stemcells.19-5-378 }}
| citations =
*{{cite journal |vauthors=Wang J, Campbell IL | title = Cytokine signaling in the brain: putting a SOCS in it? | journal = J. Neurosci. Res. | volume = 67 | issue = 4 | pages = 423–7 | year = 2002 | pmid = 11835308 | doi = 10.1002/jnr.10145 }}
*{{cite journal | author=Krebs DL, Hilton DJ |title=SOCS proteins: negative regulators of cytokine signaling. |journal=Stem Cells |volume=19 |issue= 5 |pages= 378-87 |year= 2001 |pmid= 11553846 |doi= }}
*{{cite journal |vauthors=Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ | title = The SOCS box: a tale of destruction and degradation | journal = Trends Biochem. Sci. | volume = 27 | issue = 5 | pages = 235–41 | year = 2002 | pmid = 12076535 | doi = 10.1016/S0968-0004(02)02085-6 }}
*{{cite journal | author=Wang J, Campbell IL |title=Cytokine signaling in the brain: putting a SOCS in it? |journal=J. Neurosci. Res. |volume=67 |issue= 4 |pages= 423-7 |year= 2002 |pmid= 11835308 |doi= }}
*{{cite journal |vauthors=Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ | title = A family of cytokine-inducible inhibitors of signalling | journal = Nature | volume = 387 | issue = 6636 | pages = 917–21 | year = 1997 | pmid = 9202125 | doi = 10.1038/43206 }}
*{{cite journal | author=Kile BT, Schulman BA, Alexander WS, ''et al.'' |title=The SOCS box: a tale of destruction and degradation. |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235-41 |year= 2002 |pmid= 12076535 |doi= }}
*{{cite journal |vauthors=Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A | title = A new protein containing an SH2 domain that inhibits JAK kinases | journal = Nature | volume = 387 | issue = 6636 | pages = 921–4 | year = 1997 | pmid = 9202126 | doi = 10.1038/43213 }}
*{{cite journal | author=Yoshimura A, Ohkubo T, Kiguchi T, ''et al.'' |title=A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. |journal=EMBO J. |volume=14 |issue= 12 |pages= 2816-26 |year= 1995 |pmid= 7796808 |doi= }}
*{{cite journal |author1=Ohya Ki |author2=Kajigaya S |author3=Yamashita Y |author4=Miyazato A |author5=Hatake K |author6=Miura Y |author7=Ikeda U |author8=Shimada K |author9=Ozawa K |author10=Mano H | title = SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase | journal = J. Biol. Chem. | volume = 272 | issue = 43 | pages = 27178–82 | year = 1997 | pmid = 9341160 | doi = 10.1074/jbc.272.43.27178 }}
*{{cite journal | author=Starr R, Willson TA, Viney EM, ''et al.'' |title=A family of cytokine-inducible inhibitors of signalling. |journal=Nature |volume=387 |issue= 6636 |pages= 917-21 |year= 1997 |pmid= 9202125 |doi= 10.1038/43206 }}
*{{cite journal |vauthors=Dey BR, Spence SL, Nissley P, Furlanetto RW | title = Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor | journal = J. Biol. Chem. | volume = 273 | issue = 37 | pages = 24095–101 | year = 1998 | pmid = 9727029 | doi = 10.1074/jbc.273.37.24095 }}
*{{cite journal | author=Endo TA, Masuhara M, Yokouchi M, ''et al.'' |title=A new protein containing an SH2 domain that inhibits JAK kinases. |journal=Nature |volume=387 |issue= 6636 |pages= 921-4 |year= 1997 |pmid= 9202126 |doi= 10.1038/43213 }}
*{{cite journal |vauthors=De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R | title = Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation | journal = EMBO J. | volume = 18 | issue = 4 | pages = 904–15 | year = 1999 | pmid = 10022833 | pmc = 1171183 | doi = 10.1093/emboj/18.4.904 }}
*{{cite journal | author=Minamoto S, Ikegame K, Ueno K, ''et al.'' |title=Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 1 |pages= 79-83 |year= 1997 |pmid= 9266833 |doi= 10.1006/bbrc.1997.7080 }}
*{{cite journal |vauthors=Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BJ, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M | title = The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 5 | pages = 2071–6 | year = 1999 | pmid = 10051596 | pmc = 26738 | doi = 10.1073/pnas.96.5.2071 }}
*{{cite journal | author=Ohya K, Kajigaya S, Yamashita Y, ''et al.'' |title=SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27178-82 |year= 1997 |pmid= 9341160 |doi= }}
*{{cite journal |vauthors=Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A | title = The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop | journal = EMBO J. | volume = 18 | issue = 5 | pages = 1309–20 | year = 1999 | pmid = 10064597 | pmc = 1171221 | doi = 10.1093/emboj/18.5.1309 }}
*{{cite journal | author=Dey BR, Spence SL, Nissley P, Furlanetto RW |title=Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. |journal=J. Biol. Chem. |volume=273 |issue= 37 |pages= 24095-101 |year= 1998 |pmid= 9727029 |doi= }}
*{{cite journal |vauthors=Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A, Ihle JN | title = SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality | journal = Cell | volume = 98 | issue = 5 | pages = 609–16 | year = 1999 | pmid = 10490100 | doi = 10.1016/S0092-8674(00)80048-3 }}
*{{cite journal | author=De Sepulveda P, Okkenhaug K, Rose JL, ''et al.'' |title=Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. |journal=EMBO J. |volume=18 |issue= 4 |pages= 904-15 |year= 1999 |pmid= 10022833 |doi= 10.1093/emboj/18.4.904 }}
*{{cite journal |vauthors=Yandava CN, Pillari A, Drazen JM | title = Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively | journal = Genomics | volume = 61 | issue = 1 | pages = 108–11 | year = 1999 | pmid = 10512686 | doi = 10.1006/geno.1999.5937 }}
*{{cite journal | author=Zhang JG, Farley A, Nicholson SE, ''et al.'' |title=The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 2071-6 |year= 1999 |pmid= 10051596 |doi= }}
*{{cite journal |vauthors=Okabe S, Tauchi T, Morita H, Ohashi H, Yoshimura A, Ohyashiki K | title = Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway | journal = Exp. Hematol. | volume = 27 | issue = 10 | pages = 1542–7 | year = 1999 | pmid = 10517496 | doi = 10.1016/S0301-472X(99)00094-6 }}
*{{cite journal | author=Yasukawa H, Misawa H, Sakamoto H, ''et al.'' |title=The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. |journal=EMBO J. |volume=18 |issue= 5 |pages= 1309-20 |year= 1999 |pmid= 10064597 |doi= 10.1093/emboj/18.5.1309 }}
*{{cite journal |vauthors=Ram PA, Waxman DJ | title = SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms | journal = J. Biol. Chem. | volume = 274 | issue = 50 | pages = 35553–61 | year = 2000 | pmid = 10585430 | doi = 10.1074/jbc.274.50.35553 }}
*{{cite journal | author=Marine JC, Topham DJ, McKay C, ''et al.'' |title=SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. |journal=Cell |volume=98 |issue= 5 |pages= 609-16 |year= 1999 |pmid= 10490100 |doi= }}
*{{cite journal |vauthors=Sporri B, Kovanen PE, Sasaki A, Yoshimura A, Leonard WJ | title = JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling | journal = Blood | volume = 97 | issue = 1 | pages = 221–6 | year = 2001 | pmid = 11133764 | doi = 10.1182/blood.V97.1.221 }}
*{{cite journal | author=Yandava CN, Pillari A, Drazen JM |title=Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively. |journal=Genomics |volume=61 |issue= 1 |pages= 108-11 |year= 1999 |pmid= 10512686 |doi= 10.1006/geno.1999.5937 }}
*{{cite journal |vauthors=Kawazoe Y, Naka T, Fujimoto M, Kohzaki H, Morita Y, Narazaki M, Okumura K, Saitoh H, Nakagawa R, Uchiyama Y, Akira S, Kishimoto T | title = Signal Transducer and Activator of Transcription (Stat)-Induced Stat Inhibitor 1 (Ssi-1)/Suppressor of Cytokine Signaling 1 (Socs1) Inhibits Insulin Signal Transduction Pathway through Modulating Insulin Receptor Substrate 1 (Irs-1) Phosphorylation | journal = J. Exp. Med. | volume = 193 | issue = 2 | pages = 263–9 | year = 2001 | pmid = 11208867 | pmc = 2193341 | doi = 10.1084/jem.193.2.263 }}
*{{cite journal | author=Okabe S, Tauchi T, Morita H, ''et al.'' |title=Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway. |journal=Exp. Hematol. |volume=27 |issue= 10 |pages= 1542-7 |year= 1999 |pmid= 10517496 |doi= }}
*{{cite journal |vauthors=Bourette RP, De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G | title = Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal | journal = J. Biol. Chem. | volume = 276 | issue = 25 | pages = 22133–9 | year = 2001 | pmid = 11297560 | doi = 10.1074/jbc.M101878200 }}
*{{cite journal | author=Ram PA, Waxman DJ |title=SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35553-61 |year= 2000 |pmid= 10585430 |doi= }}
*{{cite journal |vauthors=Mooney RA, Senn J, Cameron S, Inamdar N, Boivin LM, Shang Y, Furlanetto RW | title = Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance | journal = J. Biol. Chem. | volume = 276 | issue = 28 | pages = 25889–93 | year = 2001 | pmid = 11342531 | doi = 10.1074/jbc.M010579200 }}
*{{cite journal | author=Sporri B, Kovanen PE, Sasaki A, ''et al.'' |title=JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling. |journal=Blood |volume=97 |issue= 1 |pages= 221-6 |year= 2001 |pmid= 11133764 |doi= }}
*{{cite journal |vauthors=Bellezza I, Neuwirt H, Nemes C, Cavarretta IT, Puhr M, Steiner H, Minelli A, Bartsch G, Offner F, Hobisch A, Doppler W, Culig Z | title = Suppressor of Cytokine Signaling-3 Antagonizes cAMP Effects on Proliferation and Apoptosis and Is Expressed in Human Prostate Cancer | journal = American Journal of Pathology | volume = 169 | issue = 6 | pages = 2199–2208 | year = 2006 | pmid = 17148681 | pmc = 1762483 | doi = 10.2353/ajpath.2006.060171 }}
*{{cite journal | author=Kawazoe Y, Naka T, Fujimoto M, ''et al.'' |title=Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. |journal=J. Exp. Med. |volume=193 |issue= 2 |pages= 263-9 |year= 2001 |pmid= 11208867 |doi= }}
*{{cite journal |vauthors=Neuwirt H, Puhr M, Santer FR, Susani M, Doppler W, Marcias G, Rauch V, Brugger M, Hobisch A, Kenner L, Culig Z | title = Suppressor of Cytokine Signaling (SOCS)-1 Is Expressed in Human Prostate Cancer and Exerts Growth-Inhibitory Function through Down-Regulation of Cyclins and Cyclin-Dependent Kinases | journal = American Journal of Pathology | volume = 174 | issue = 5 | pages = 921–1930 | year = 2009 | pmid = 19342366 | pmc = 2671279 | doi = 10.2353/ajpath.2009.080751 }}
*{{cite journal | author=Bourette RP, De Sepulveda P, Arnaud S, ''et al.'' |title=Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22133-9 |year= 2001 |pmid= 11297560 |doi= 10.1074/jbc.M101878200 }}
{{Refend}}
*{{cite journal | author=Mooney RA, Senn J, Cameron S, ''et al.'' |title=Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25889-93 |year= 2001 |pmid= 11342531 |doi= 10.1074/jbc.M010579200 }}
}}
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{{JAK-STAT signaling pathway}}


[[Category:Cell signaling]]
[[Category:Cell signaling]]
[[Category:Signal transduction]]
[[Category:Signal transduction]]

Revision as of 08:53, 15 September 2017


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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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View/Edit Human

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene.[1][2] SOCS1 orthologs [3] have been identified in several mammals for which complete genome data are available.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), GM-CSF, and interferon-gamma (IFN-γ). The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival.[4]

Interactions

Suppressor of cytokine signaling 1 has been shown to interact with:

See also

References

  1. ↑ Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A (August 1995). "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors". EMBO J. 14 (12): 2816–26. PMC 398400. PMID 7796808.
  2. ↑ Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (September 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.
  3. ↑ "OrthoMaM phylogenetic marker: SOCS1 coding sequence".
  4. ↑ "Entrez Gene: SOCS1 suppressor of cytokine signaling 1".
  5. ↑ De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R (February 1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". EMBO J. 18 (4): 904–15. doi:10.1093/emboj/18.4.904. PMC 1171183. PMID 10022833.
  6. ↑ Bourette RP, De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G (June 2001). "Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal". J. Biol. Chem. 276 (25): 22133–9. doi:10.1074/jbc.M101878200. PMID 11297560.
  7. ↑ Ram PA, Waxman DJ (Dec 1999). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". J. Biol. Chem. 274 (50): 35553–61. doi:10.1074/jbc.274.50.35553. PMID 10585430.
  8. ↑ Rui L, Yuan M, Frantz D, Shoelson S, White MF (November 2002). "SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2". J. Biol. Chem. 277 (44): 42394–8. doi:10.1074/jbc.C200444200. PMID 12228220.
  9. ↑ Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A (March 1999). "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop". EMBO J. 18 (5): 1309–20. doi:10.1093/emboj/18.5.1309. PMC 1171221. PMID 10064597.
  10. ↑ Dif F, Saunier E, Demeneix B, Kelly PA, Edery M (Dec 2001). "Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor". Endocrinology. 142 (12): 5286–93. doi:10.1210/endo.142.12.8549. PMID 11713228.
  11. ↑ Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A (June 1997). "A new protein containing an SH2 domain that inhibits JAK kinases". Nature. 387 (6636): 921–4. doi:10.1038/43213. PMID 9202126.
  12. ↑ Pezet A, Favre H, Kelly PA, Edery M (August 1999). "Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling". J. Biol. Chem. 274 (35): 24497–502. doi:10.1074/jbc.274.35.24497. PMID 10455112.
  13. ↑ Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O (May 2002). "Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1". Mol. Cell. Biol. 22 (10): 3316–26. doi:10.1128/mcb.22.10.3316-3326.2002. PMC 133778. PMID 11971965.
  14. ↑ Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (October 1997). "Cloning and characterization of novel CIS family genes". Biochem. Biophys. Res. Commun. 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848.
  15. ↑ Ohya Ki; Kajigaya S; Yamashita Y; Miyazato A; Hatake K; Miura Y; Ikeda U; Shimada K; Ozawa K; Mano H (October 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". J. Biol. Chem. 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. PMID 9341160.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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