Sulfiram: Difference between revisions

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{{Drugbox
{{Drugbox
| IUPAC_name = ''N'',''N'',''N''&prime;,''N''&prime;-tetraethyldicarbonotrithioic diamide
| IUPAC_name = ''N'',''N'',''N''&prime;,''N''&prime;-tetraethyldicarbonotrithioic diamide
| image = Sulfiram.svg
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<!--Clinical data-->

Revision as of 13:02, 11 March 2015

Sulfiram
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Topical
ATCvet code
Pharmacokinetic data
BioavailabilityVery low
ExcretionRenal, unchanged
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC10H20N2S3
Molar mass264.47 g·mol−1

Sulfiram (INN) or monosulfiram, trade name Tetmosol, is an ectoparasiticide used in the treatment and prevention of scabies.[1] It is usually sold as a solution or medicated soap, sometimes in combination with benzyl benzoate.

Sulfiram is now rarely used, but, as of 2010, is still available in Brazil, India, and South Africa (as monotherapy) and France (with benzyl benzoate).[1]

Adverse effects

Dizziness, headache, fatigue and erythematous rash may occur.[2] A single case of toxic epidermal necrolysis was reported in 1968.[3]

Sulfiram is structurally related to disulfiram (Antabuse), and readily converts to disulfiram when exposed to light. Like disulfiram, it can produce an unpleasant reaction when consumed with alcohol.[1][4]

References

  1. 1.0 1.1 1.2 Sweetman, Sean C., ed. (2009). "Pesticides and repellents". Martindale: the complete drug reference (36th ed.). London: Pharmaceutical Press. p. 2050. ISBN 978-0-85369-840-1.
  2. [No authors listed] (2009). "Sarfiram - Bula". Bulário de Remédios Comerciais (in Portuguese). MedicinaNET. Retrieved 2010-08-11.
  3. Copeman PW (March 1968). "Toxic epidermal necrolysis caused by skin hypersensitivity to monosulfiram". British Medical Journal. 1 (5592): 623–4. doi:10.1136/bmj.1.5592.623. PMC 1985336. PMID 5637574.
  4. Mays DC, Nelson AN, Benson LM, Johnson KL, Naylor S, Lipsky JJ (November 1994). "Photolysis of sulfiram: a mechanism for its disulfiram-like reaction". Biochemical Pharmacology. 48 (10): 1917–25. doi:10.1016/0006-2952(94)90590-8. PMID 7986203.

External links


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