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(Created page with "__NOTOC__ {{Stroke}} {{CMG}}; {{AE}} ==Definition== ==Causes== ===Life Threatening Causes=== Life-threatening causes include conditions which may result in death or permanent ...")
 
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===Common Causes===
===Common Causes===
==Management==
==Management==
{{familytree/start}}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | A01 |-|-|-|-|-|-| A02 |A01=<u>Evaluation</u><br>'''Goal: Evaluation done within 60 mins of patient's arrival'''<ref name="Jauch-2013">{{Cite journal  | last1 = Jauch | first1 = EC. | last2 = Saver | first2 = JL. | last3 = Adams | first3 = HP. | last4 = Bruno | first4 = A. | last5 = Connors | first5 = JJ. | last6 = Demaerschalk | first6 = BM. | last7 = Khatri | first7 = P. | last8 = McMullan | first8 = PW. |last9 = Qureshi | first9 = AI. | title = Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. | journal = Stroke | volume = 44 | issue = 3 | pages = 870-947 | month = Mar | year = 2013 |doi = 10.1161/STR.0b013e318284056a | PMID = 23370205 }}</ref><br><br>Check vitals<br>ABCs<br>Rapid Hx - time of onset, time of arrival at the ED, medications (especially anticoagulants)<br>Rapid physical exam - neuro exam, '''NIHSS'''<br>Activate stroke team<br>'''Stat fingerstick'''<br>Labs<br>EKG, troponin, CXR<br>NPO<br>Obtain stroke protocol|A02=<u>Rule out DD</u><br>Seizure, syncope, migraine, hypoglycemia}}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | |  }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | B01 |-|-|-| B02 |-|-| B03 | | | | | | | | | | | | | | | | | |B01=Non-contrast enhanced CT (or MRI) to r/o hemorrhage|B02='''Bleed positive'''|B03='''Hemorrhagic stroke'''}}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | |!| | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | C01 | | | | | | | | | C02 | | | | | | | | | | | | | | | | | |C01='''Bleed negative'''|C02=Hemorrhagic stroke algorithm}}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | D01 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |D01='''Acute ischemic stroke'''}}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | |  }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | E01 | | | | | | | | | | | | | | | | | | | | | | | | | | | |E01=Time of onset}}
{{familytree | | | | | | | | | | | | | | | | | | | | |,|-|-|-|-|-|-|+|-|-|-|-|-|-|.| | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | F01 | | | | | F02 | | | | | F03 | | | | | | | | | | | | | | | | | | | | | | |F01='''<3 hours'''|F02='''3 -4.5 hours'''|F03='''>4.5 hours'''}}
{{familytree | | | | | | | | | | | | | | | | | | | | |!| | | | | | |!| | | | | | |!| | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | G01 | | | | | G02 | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | |G01=Eligibility criteria for IV rTPA|G02=Consider rTPA after '''excluding''' patients >80 years old, those taking anticoagulants regardless of INR, baseline NIHSS >25, those with imaging evidence of ischemic injury involving >1/3 of the MCA territory, or those with a history of both stroke and diabetes mellitus}}
{{familytree | | | | | | | | | | | | | | | | | | | | |!| | | | | | |!| | | | | | |!| | | | | | | | | | | | | | | | | | | | |  }}
{{familytree | | | | | | | | | | | | |,|-|-|-|-|-|-|-|^|-|-|-|.| | |!| | | | | | |!| | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | H01 | | | | | | | | | | H02 | |!| | | | | | H03 | | | | | | | | | | | | | | | | | | | | | | |H01=Eligible|H02=Not eligible|H03=Blood pressure control algorithm<br><br>Treat fever with IV antipyretics}}
{{familytree | | | | | | | | | | | | |!| | | | | | | | | | | | | | |!| | | | | | |!| | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | |,|-|-|-|^|-|-|-|.| | | | | | | | | | |!| | | | | | |!| | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | I01 | | | | | | I02 | | | | | | | | | |!| | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | ||I01='''BP≤180/110'''|I02='''BP≥180/110'''}}
{{familytree | | | | | | | | |!| | | | | | | |!| | | | | | | | | | |!| | | | | | |!| | | | | | | | | | | | | | | | | | | | |  }}
{{familytree | | | | | | | | J01 | | | | | | JO2 | | | | | | | | | |!| | | | | | |!| | | | | | | | | | | | | | | | | | | | | | |J01=IV rTPA 0.9 mg/kg (maximum of 90 mg) with 10% given as intravenous bolus over 1 minute and the rest as IV infusion over 1 hour|JO2=Commence IV antihypertensives}}
{{familytree | | | | | | | | |!| | | | | | | | | | | | | | | | | | |!| | | | | | |!| | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | |!| | | | | | | | | | | | | | | | | | |!| | | | | | |!| | | | | | | | | | | | | | | | | | | | | |}}
{{familytree | | | | | | | | K01 |-|-|-|-|-|-|-|-|-|-|-|-|-|-|-|-|-|+|-|-|-|-|-|-|'| | | | | | | | | | | | | | | | | | | | | |K01=Admit ICU for BP monitoring + bleeding complications<br>Vitals<br>Neurocheck hourly<br>Aspiration precautions}}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | | | |}}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | L01 | | | | | | | | | | | | | | | | | | | | | | | | | | | |L01='''After 24 hours post rTPA or no rTPA'''}}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | M01 | | | | | | | | | | | | | | | | | | | | | | | | | | | |M01=Follow-up head CT/MRI before commencing antiplatelets}}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | | |,|-|-|-|-|-|+|-|-|-|-|-|-|.| | | | | | | | | | | | | | | | | | | | | | |}}
{{familytree | | | | | | | | | | | | | | | | | | | | | N01 | | | | N02 | | | | | N03 | | | | | | | | | | | | | | | | | | | | | | |N01='''ASA''' 325 mg (if no contraindication)<br>'''Statins'''<br>'''DVT prophylaxis'''|N02=PTOT evaluation<br>Speech and swallow evaluation|N03='''Investigate the cause'''<br>MRA/CTA/carotid duplex<br>Venous doppler USS<br>Echocardiography}}
{{familytree/end}}
==Dos==
==Dos==
==Don'ts==
==Don'ts==

Revision as of 21:27, 3 December 2013

Stroke Main page

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Epidemiology and Demographics

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NIH stroke scale
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Natural History, Complications and Prognosis

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Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

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Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Definition

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Management

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Evaluation
Goal: Evaluation done within 60 mins of patient's arrival[1]

Check vitals
ABCs
Rapid Hx - time of onset, time of arrival at the ED, medications (especially anticoagulants)
Rapid physical exam - neuro exam, NIHSS
Activate stroke team
Stat fingerstick
Labs
EKG, troponin, CXR
NPO
Obtain stroke protocol
 
 
 
 
 
 
Rule out DD
Seizure, syncope, migraine, hypoglycemia
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
{{{ }}}
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Non-contrast enhanced CT (or MRI) to r/o hemorrhage
 
 
 
Bleed positive
 
 
Hemorrhagic stroke
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bleed negative
 
 
 
 
 
 
 
 
Hemorrhagic stroke algorithm
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Acute ischemic stroke
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
{{{ }}}
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Time of onset
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
<3 hours
 
 
 
 
3 -4.5 hours
 
 
 
 
>4.5 hours
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Eligibility criteria for IV rTPA
 
 
 
 
Consider rTPA after excluding patients >80 years old, those taking anticoagulants regardless of INR, baseline NIHSS >25, those with imaging evidence of ischemic injury involving >1/3 of the MCA territory, or those with a history of both stroke and diabetes mellitus
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
{{{ }}}
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Eligible
 
 
 
 
 
 
 
 
 
Not eligible
 
 
 
 
 
 
 
 
Blood pressure control algorithm

Treat fever with IV antipyretics
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
BP≤180/110
 
 
 
 
 
BP≥180/110
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
{{{ }}}
 
 
 
 
 
 
 
IV rTPA 0.9 mg/kg (maximum of 90 mg) with 10% given as intravenous bolus over 1 minute and the rest as IV infusion over 1 hour
 
 
 
 
 
Commence IV antihypertensives
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Admit ICU for BP monitoring + bleeding complications
Vitals
Neurocheck hourly
Aspiration precautions
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
After 24 hours post rTPA or no rTPA
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Follow-up head CT/MRI before commencing antiplatelets
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ASA 325 mg (if no contraindication)
Statins
DVT prophylaxis
 
 
 
PTOT evaluation
Speech and swallow evaluation
 
 
 
 
Investigate the cause
MRA/CTA/carotid duplex
Venous doppler USS
Echocardiography
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Dos

Don'ts

References

  1. Jauch, EC.; Saver, JL.; Adams, HP.; Bruno, A.; Connors, JJ.; Demaerschalk, BM.; Khatri, P.; McMullan, PW.; Qureshi, AI. (2013). "Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association". Stroke. 44 (3): 870–947. doi:10.1161/STR.0b013e318284056a. PMID 23370205. Unknown parameter |month= ignored (help)

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