St. Louis encephalitis laboratory findings: Difference between revisions

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==Overview==
==Overview==
In acute SLEV neuroinvasive disease cases, cerebrospinal fluid (CSF) examination shows a moderate (typically lymphocytic) pleocytosis. CSF protein is elevated in about a half to two-thirds of cases. SLEV is difficult to isolate from clinical samples and almost all isolates have come from brain tissue or CSF. In the absence of a sensitive and non-invasive virus detection method, serologic testing is the primary method for diagnosing SLEV infection. Combined with a consistent clinico-epidemiologic presentation, a rapid and accurate diagnosis of acute neuroinvasive SLEV disease can be made by the detection of SLEV-specific IgM antibody in serum or CSF. SLEV IgM tests are available commercially, in some state health department laboratories, and at CDC. A positive SLEV IgM test result should be confirmed by neutralizing antibody testing of acute- and convalescent-phase serum specimens at a state public health laboratory or CDC. To submit specimens for testing at CDC, contact your state health department. All SLEV disease cases should be reported to local public health authorities.


==Laboratory Findings==
==Laboratory Findings==
The diagnostic method of choice for St. Louis encephalitis is laboratory testing. In St. Louis encephalitis, cerebrospinal fluid examination shows a moderate (typically lymphocytic) pleocytosis. An elevated concentration of CSF protein is diagnostic of St. Louis encephalitis. In the absence of a sensitive and non-invasive virus detection method, serologic testing is the primary method for diagnosing SLEV infection. A rapid and accurate diagnosis of St. Louis encephalitis can be made by the detection of St. Louis encephalitis-specific IgM antibody in serum or CSF.<ref name= SLEV>Saint Louis Encephalitis. Centers for Disease Prevention and Control (2009). https://www.cdc.gov/sle/technical/symptoms.html Accessed on August 1, 2016.</ref>
A positive St. Louis encephalitis IgM test result should be confirmed by neutralizing antibody testing of acute- and convalescent-phase serum specimens at the CDC. [[CDC|CDChttps://www.cdc.gov/sle/technical/symptoms.html]]


==References==
==References==

Revision as of 12:13, 1 August 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anthony Gallo, B.S. [2]; Contributor(s): Vishnu Vardhan Serla M.B.B.S. [3]

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Overview

Laboratory Findings

The diagnostic method of choice for St. Louis encephalitis is laboratory testing. In St. Louis encephalitis, cerebrospinal fluid examination shows a moderate (typically lymphocytic) pleocytosis. An elevated concentration of CSF protein is diagnostic of St. Louis encephalitis. In the absence of a sensitive and non-invasive virus detection method, serologic testing is the primary method for diagnosing SLEV infection. A rapid and accurate diagnosis of St. Louis encephalitis can be made by the detection of St. Louis encephalitis-specific IgM antibody in serum or CSF.[1]

A positive St. Louis encephalitis IgM test result should be confirmed by neutralizing antibody testing of acute- and convalescent-phase serum specimens at the CDC. CDChttps://www.cdc.gov/sle/technical/symptoms.html

References

  1. Saint Louis Encephalitis. Centers for Disease Prevention and Control (2009). https://www.cdc.gov/sle/technical/symptoms.html Accessed on August 1, 2016.

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