Squamous cell carcinoma of the lung staging: Difference between revisions

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{{Squamous cell carcinoma of the lung}}
{{Squamous cell carcinoma of the lung}}
{{CMG}}; {{AE}} {{SC}}
{{CMG}}; {{AE}} {{SC}}
==Overview==
Squamous cell carcinoma of the lung may be classified into several subtypes based on [[TNM]] and [[UICC]] staging system.<ref name=canadian>Stages of non–small cell lung cancer. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/lung/staging/?region=ab</ref>
==Staging==
'''TNM staging'''<ref name=canadian>Stages of non–small cell lung cancer. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/lung/staging/?region=ab</ref>
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
|valign=top|
|+
! style="background: #4479BA; width: 100px;" | {{fontcolor|#FFF|TNM}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF| Definition}}
|-
| style="padding: 5px 5px; background: #DCDCDC;" |TX
| style="padding: 5px 5px; background: #F5F5F5;" |The primary [[tumour]] cannot be assessed, or there are [[malignant]] [[cell (biology)|cells]] in the [[sputum]] or [[bronchoalveolar lavage]] but not seen on imaging or [[bronchoscopy]].
|-
| style="padding: 5px 5px; background: #DCDCDC;" |T0
| style="padding: 5px 5px; background: #F5F5F5;" |No evidence of primary tumor.
|-
| style="padding: 5px 5px; background: #DCDCDC;" |Tis
| style="padding: 5px 5px; background: #F5F5F5;" |[[Carcinoma in situ]].
|-
| style="padding: 5px 5px; background: #DCDCDC;" rowspan=3|T1
| style="padding: 5px 5px; background: #F5F5F5;" |Tumour is 3 cm or less in size and has not spread to the visceral pleura or the main bronchi.
|-
| style="padding: 5px 5px; background: #F5F5F5;" |T1a – Tumour is smaller than 2 cm.
|-
| style="padding: 5px 5px; background: #F5F5F5;" |T1b – Tumour is larger than 2 cm, but smaller than 3 cm.
|-
| style="padding: 5px 5px; background: #DCDCDC;" rowspan=3 |T2
| style="padding: 5px 5px; background: #F5F5F5;" |Tumour is larger than 3 cm, but smaller than 7 cm; or the tumour has any of the following features: Cancer has spread to the main bronchi, but is not closer than 2 cm to the carina; Cancer has spread to the visceral pleura; Tumour is associated with obstructive pneumonitis or atelectasis.
|-
| style="padding: 5px 5px; background: #F5F5F5;" |T2a – Tumour is larger than 3 cm, but 5 cm or less in size.
|-
| style="padding: 5px 5px; background: #F5F5F5;" |T2b – Tumour is larger than 5 cm, but 7 cm or less in size
|-
| style="padding: 5px 5px; background: #DCDCDC;" |T3
| style="padding: 5px 5px; background: #F5F5F5;" |A tumour with any of: Invasion of the chest wall, [[Thoracic diaphragm|diaphragm]], [[mediastinum|mediastinal]] pleura, or parietal [[pericardium]]; Extending into the main bronchus, within 2 cm of the carina, but not involving the carina; Obstructive pneumonitis of the entire lung.
|-
| style="padding: 5px 5px; background: #DCDCDC;" |T4
| style="padding: 5px 5px; background: #F5F5F5;" |A tumour with any of: Invasion of the mediastinum, [[heart]], great vessels, [[Vertebrate trachea|trachea]], [[oesophagus]], [[vertebra]], or carina; Separate tumour nodules in the same lobe; Malignant [[pleural effusion]].
|-
| style="padding: 0 5px; background: #4479BA" colspan=3 |{{fontcolor|#FFF| Regional Lymph Nodes}}
|-
| style="padding: 5px 5px; background: #DCDCDC;" |NX
| style="padding: 5px 5px; background: #F5F5F5;" |[[Lymph node]]s cannot be assessed.
|-
| style="padding: 5px 5px; background: #DCDCDC;" |N0
| style="padding: 5px 5px; background: #F5F5F5;" |No lymph nodes involved.
|-
| style="padding: 5px 5px; background: #DCDCDC;" |N1
| style="padding: 5px 5px; background: #F5F5F5;" |[[Metastasis]] to [[ipsilateral]] peribronchial or ipsilateral hilar lymph nodes.
|-
| style="padding: 5px 5px; background: #DCDCDC;" |N2
| style="padding: 5px 5px; background: #F5F5F5;" |Metastasis to ipsilateral mediastinal or subcarinal lymph nodes.
|-
| style="padding: 5px 5px; background: #DCDCDC;" |N3
| style="padding: 5px 5px; background: #F5F5F5;" |Metastasis to any of: Ipsilateral supraclavicular lymph nodes; Ipsilateral scalene lymph nodes; [[Contralateral]] lymph nodes.
|-|-
| style="padding: 0 5px; background: #4479BA" colspan=3 |{{fontcolor|#FFF| Distant Metastasis}}
|-
| style="padding: 5px 5px; background: #DCDCDC;" |M0
| style="padding: 5px 5px; background: #F5F5F5;" |No distant metastasis.
|-
| style="padding: 5px 5px; background: #DCDCDC;" rowspan=3|M1
| style="padding: 5px 5px; background: #F5F5F5;" |Distant metastasis is present.
|-
| style="padding: 5px 5px; background: #F5F5F5;" |M1a – Any one of the following: Separate tumour nodule(s) in the opposite lung; Tumour nodules on the parietal pleura; Pleural effusion or pericardial effusion.
|-
| style="padding: 5px 5px; background: #F5F5F5;" |M1b – Distant metastasis.
|}
'''UICC staging'''<ref name=canadian>Stages of non–small cell lung cancer. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/lung/staging/?region=ab</ref>
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
|valign=top|
|+
! style="background: #4479BA; width: 100px;" | {{fontcolor|#FFF|Stage}}
! style="background: #4479BA; width: 100px;" | {{fontcolor|#FFF| T}}
! style="background: #4479BA; width: 100px;" | {{fontcolor|#FFF| N}}
! style="background: #4479BA; width: 100px;" | {{fontcolor|#FFF| M}}
|-
| style="padding: 5px 5px; background: #DCDCDC;" |Occult carcinoma
| style="padding: 5px 5px; background: #F5F5F5;" |TX
| style="padding: 5px 5px; background: #F5F5F5;" |N0
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #DCDCDC;" |Stage 0
| style="padding: 5px 5px; background: #F5F5F5;" |Tis
| style="padding: 5px 5px; background: #F5F5F5;" |N0
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #DCDCDC;" |Stage IA
| style="padding: 5px 5px; background: #F5F5F5;" |T1
| style="padding: 5px 5px; background: #F5F5F5;" |N0
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #DCDCDC;" |Stage IB
| style="padding: 5px 5px; background: #F5F5F5;" |T2a
| style="padding: 5px 5px; background: #F5F5F5;" |N0
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #DCDCDC;" rowspan=3 |Stage IIA
| style="padding: 5px 5px; background: #F5F5F5;" |T2b
| style="padding: 5px 5px; background: #F5F5F5;" |N0
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #F5F5F5;" |T1
| style="padding: 5px 5px; background: #F5F5F5;" |N1
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #F5F5F5;" |T2a
| style="padding: 5px 5px; background: #F5F5F5;" |N1
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #DCDCDC;" rowspan="2"|Stage IIB
| style="padding: 5px 5px; background: #F5F5F5;" |T2b
| style="padding: 5px 5px; background: #F5F5F5;" |N1
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #F5F5F5;" |T3
| style="padding: 5px 5px; background: #F5F5F5;" |N0
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #DCDCDC;" rowspan=6|Stage IIIA
| style="padding: 5px 5px; background: #F5F5F5;" |T1
| style="padding: 5px 5px; background: #F5F5F5;" |N2
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #F5F5F5;" |T2
| style="padding: 5px 5px; background: #F5F5F5;" |N2
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #F5F5F5;" |T3
| style="padding: 5px 5px; background: #F5F5F5;" |N1
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #F5F5F5;" |T3
| style="padding: 5px 5px; background: #F5F5F5;" |N2
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #F5F5F5;" |T4
| style="padding: 5px 5px; background: #F5F5F5;" |N0
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #F5F5F5;" |T4
| style="padding: 5px 5px; background: #F5F5F5;" |N1
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #DCDCDC;" rowspan="2"|Stage IIIB
| style="padding: 5px 5px; background: #F5F5F5;" |T4
| style="padding: 5px 5px; background: #F5F5F5;" |N2
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #F5F5F5;" |Any T   
| style="padding: 5px 5px; background: #F5F5F5;" |N3
| style="padding: 5px 5px; background: #F5F5F5;" |M0
|-
| style="padding: 5px 5px; background: #DCDCDC;" |Stage IV
| style="padding: 5px 5px; background: #F5F5F5;" |Any T 
| style="padding: 5px 5px; background: #F5F5F5;" |Any N
| style="padding: 5px 5px; background: #F5F5F5;" |M1
|}


==References==
==References==

Revision as of 19:23, 6 January 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

Squamous cell carcinoma of the lung may be classified into several subtypes based on TNM and UICC staging system.[1]

Staging

TNM staging[1]

TNM Definition
TX The primary tumour cannot be assessed, or there are malignant cells in the sputum or bronchoalveolar lavage but not seen on imaging or bronchoscopy.
T0 No evidence of primary tumor.
Tis Carcinoma in situ.
T1 Tumour is 3 cm or less in size and has not spread to the visceral pleura or the main bronchi.
T1a – Tumour is smaller than 2 cm.
T1b – Tumour is larger than 2 cm, but smaller than 3 cm.
T2 Tumour is larger than 3 cm, but smaller than 7 cm; or the tumour has any of the following features: Cancer has spread to the main bronchi, but is not closer than 2 cm to the carina; Cancer has spread to the visceral pleura; Tumour is associated with obstructive pneumonitis or atelectasis.
T2a – Tumour is larger than 3 cm, but 5 cm or less in size.
T2b – Tumour is larger than 5 cm, but 7 cm or less in size
T3 A tumour with any of: Invasion of the chest wall, diaphragm, mediastinal pleura, or parietal pericardium; Extending into the main bronchus, within 2 cm of the carina, but not involving the carina; Obstructive pneumonitis of the entire lung.
T4 A tumour with any of: Invasion of the mediastinum, heart, great vessels, trachea, oesophagus, vertebra, or carina; Separate tumour nodules in the same lobe; Malignant pleural effusion.
Regional Lymph Nodes
NX Lymph nodes cannot be assessed.
N0 No lymph nodes involved.
N1 Metastasis to ipsilateral peribronchial or ipsilateral hilar lymph nodes.
N2 Metastasis to ipsilateral mediastinal or subcarinal lymph nodes.
N3 Metastasis to any of: Ipsilateral supraclavicular lymph nodes; Ipsilateral scalene lymph nodes; Contralateral lymph nodes.
Distant Metastasis
M0 No distant metastasis.
M1 Distant metastasis is present.
M1a – Any one of the following: Separate tumour nodule(s) in the opposite lung; Tumour nodules on the parietal pleura; Pleural effusion or pericardial effusion.
M1b – Distant metastasis.

UICC staging[1]

Stage T N M
Occult carcinoma TX N0 M0
Stage 0 Tis N0 M0
Stage IA T1 N0 M0
Stage IB T2a N0 M0
Stage IIA T2b N0 M0
T1 N1 M0
T2a N1 M0
Stage IIB T2b N1 M0
T3 N0 M0
Stage IIIA T1 N2 M0
T2 N2 M0
T3 N1 M0
T3 N2 M0
T4 N0 M0
T4 N1 M0
Stage IIIB T4 N2 M0
Any T N3 M0
Stage IV Any T Any N M1

References

  1. 1.0 1.1 1.2 Stages of non–small cell lung cancer. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/lung/staging/?region=ab


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