Spontaneous coronary artery dissection epidemiology and demographics: Difference between revisions

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===Gender===
===Gender===


SCAD has a strong predilection for young women with no or minimal traditional atherosclerotic risk factors. Studies indicate that SCAD accounts for approximately 25% of women aged < 50 who present with [[Myocardial infarction|MI]].<ref name="pmid24726091">{{cite journal| author=Saw J, Aymong E, Mancini GB, Sedlak T, Starovoytov A, Ricci D| title=Nonatherosclerotic coronary artery disease in young women. | journal=Can J Cardiol | year= 2014 | volume= 30 | issue= 7 | pages= 814-9 | pmid=24726091 | doi=10.1016/j.cjca.2014.01.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24726091  }} </ref>


===Race===
===Race===
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SCAD has a strong predilection for young women with no or minimal traditional atherosclerotic risk factors. Studies indicate that SCAD accounts for approximately 25% of women aged < 50 who present with [[Myocardial infarction|MI]].<ref name="pmid24726091">{{cite journal| author=Saw J, Aymong E, Mancini GB, Sedlak T, Starovoytov A, Ricci D| title=Nonatherosclerotic coronary artery disease in young women. | journal=Can J Cardiol | year= 2014 | volume= 30 | issue= 7 | pages= 814-9 | pmid=24726091 | doi=10.1016/j.cjca.2014.01.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24726091  }} </ref> SCAD should be highly suspected in any young subject presenting with acute myocardial ischemia, but without traditional risk factors for [[coronary artery disease]] ([[CAD]]).The [[left anterior descending artery]] (LAD) is the most commonly affected artery.<ref name="pmid19046896">{{cite journal |author=Vanzetto G, Berger-Coz E, Barone-Rochette G, ''et al.'' |title=Prevalence, therapeutic management and medium-term prognosis of spontaneous coronary artery dissection: results from a database of 11,605 patients |journal=[[European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery]] |volume=35 |issue=2 |pages=250–4 |year=2009 |month=February |pmid=19046896 |doi=10.1016/j.ejcts.2008.10.023 |url=}}</ref><ref name="pmid18830003">{{cite journal |author=Kamran M, Guptan A, Bogal M|title=Spontaneous coronary artery dissection: case series and review |journal=J Invasive Cardiol |volume=20 |issue=10 |pages=553–9 |year=2008 |month=October |pmid=18830003|doi= |url=http://jic.epubxpress.com/link/jic/2008/oct/90?s=0}}</ref>  Although multivessel SCAD has been reported, single vessel SCAD is much more common. In women [[LAD]] is frequently involved<ref name="pmid19046896">{{cite journal |author=Vanzetto G, Berger-Coz E, Barone-Rochette G, ''et al.'' |title=Prevalence, therapeutic management and medium-term prognosis of spontaneous coronary artery dissection: results from a database of 11,605 patients |journal=[[European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery]] |volume=35 |issue=2 |pages=250–4 |year=2009 |month=February |pmid=19046896 |doi=10.1016/j.ejcts.2008.10.023 |url=}}</ref> while in men [[right coronary artery]] is involved more often. Men tend to present at a slightly later age and also with evidence of CAD risk factors.  
The [[left anterior descending artery]] (LAD) is the most commonly affected artery.<ref name="pmid19046896">{{cite journal |author=Vanzetto G, Berger-Coz E, Barone-Rochette G, ''et al.'' |title=Prevalence, therapeutic management and medium-term prognosis of spontaneous coronary artery dissection: results from a database of 11,605 patients |journal=[[European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery]] |volume=35 |issue=2 |pages=250–4 |year=2009 |month=February |pmid=19046896 |doi=10.1016/j.ejcts.2008.10.023 |url=}}</ref><ref name="pmid18830003">{{cite journal |author=Kamran M, Guptan A, Bogal M|title=Spontaneous coronary artery dissection: case series and review |journal=J Invasive Cardiol |volume=20 |issue=10 |pages=553–9 |year=2008 |month=October |pmid=18830003|doi= |url=http://jic.epubxpress.com/link/jic/2008/oct/90?s=0}}</ref>  Although multivessel SCAD has been reported, single vessel SCAD is much more common. In women [[LAD]] is frequently involved<ref name="pmid19046896">{{cite journal |author=Vanzetto G, Berger-Coz E, Barone-Rochette G, ''et al.'' |title=Prevalence, therapeutic management and medium-term prognosis of spontaneous coronary artery dissection: results from a database of 11,605 patients |journal=[[European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery]] |volume=35 |issue=2 |pages=250–4 |year=2009 |month=February |pmid=19046896 |doi=10.1016/j.ejcts.2008.10.023 |url=}}</ref> while in men [[right coronary artery]] is involved more often. Men tend to present at a slightly later age and also with evidence of CAD risk factors.  


Observational studies have reported that SCAD is common among young women during their peripartum period<ref name="pmid19708230">{{cite journal |author=Fontanelli A, Olivari Z, La Vecchia L, ''et al.'' |title=Spontaneous dissections of coronary arteries and acute coronary syndromes: rationale and design of the DISCOVERY, a multicenter prospective registry with a case-control group |journal=[[Journal of Cardiovascular Medicine (Hagerstown, Md.)]] |volume=10 |issue=1 |pages=94–9 |year=2009 |month=January |pmid=19708230 |doi= |url=}}</ref> or in association with use of oral contraceptives. About 80% of SCAD cases reported so far have occurred in young women, especially those taking [[birth control|oral contraceptives]] [[OCP|(OCP]]s) or those in the peripartum period.<ref>{{cite journal |author=Narasimhan, S|title=Spontaneous coronary artery dissection (SCAD)|journal=IJTCVS |volume=20 |issue=4 |pages=189-91 |year=2004 |pmid= |doi= 10.1007/s12055-004-0084-x|url=http://medind.nic.in/ibq/t04/i4/ibqt04i4p189.pdf}}</ref><ref name="pmid8673763">{{cite journal |author=Zampieri P, Aggio S, Roncon L, ''et al.''|title=Follow up after spontaneous coronary artery dissection: a report of five cases |journal=[[Heart (British Cardiac Society)]] |volume=75 |issue=2|pages=206–9 |year=1996 |month=February |pmid=8673763 |pmc=484263 |doi= |url=}}</ref><ref name="pmid10700066">{{cite journal |author=Cohen DE, Strimike CL|title=A case of multiple spontaneous coronary artery dissections |journal=[[Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions]] |volume=49 |issue=3 |pages=318–20 |year=2000 |month=March |pmid=10700066 |doi= |url=}}</ref> Possible mechanisms underlying increased prevalence of SCAD in this population include: changes in the arterial wall media due to increasing hormone levels, shear stress during labor, fragmentation of reticulin fibers, loosening of ground substance, and hypertrophy of smooth muscle.<ref name="pmid19127318">{{cite journal |author=Van den Branden BJ, Bruggeling WA, Corbeij HM, Dunselman PH |title=Spontaneous coronary artery dissection in the postpartum period |journal=Neth Heart J |volume=16 |issue=12 |pages=412–4 |year=2008|month=December |pmid=19127318 |pmc=2612109 |doi= |url=}}</ref>
Observational studies have reported that SCAD is common among young women during their peripartum period<ref name="pmid19708230">{{cite journal |author=Fontanelli A, Olivari Z, La Vecchia L, ''et al.'' |title=Spontaneous dissections of coronary arteries and acute coronary syndromes: rationale and design of the DISCOVERY, a multicenter prospective registry with a case-control group |journal=[[Journal of Cardiovascular Medicine (Hagerstown, Md.)]] |volume=10 |issue=1 |pages=94–9 |year=2009 |month=January |pmid=19708230 |doi= |url=}}</ref> or in association with use of oral contraceptives. About 80% of SCAD cases reported so far have occurred in young women, especially those taking [[birth control|oral contraceptives]] [[OCP|(OCP]]s) or those in the peripartum period.<ref>{{cite journal |author=Narasimhan, S|title=Spontaneous coronary artery dissection (SCAD)|journal=IJTCVS |volume=20 |issue=4 |pages=189-91 |year=2004 |pmid= |doi= 10.1007/s12055-004-0084-x|url=http://medind.nic.in/ibq/t04/i4/ibqt04i4p189.pdf}}</ref><ref name="pmid8673763">{{cite journal |author=Zampieri P, Aggio S, Roncon L, ''et al.''|title=Follow up after spontaneous coronary artery dissection: a report of five cases |journal=[[Heart (British Cardiac Society)]] |volume=75 |issue=2|pages=206–9 |year=1996 |month=February |pmid=8673763 |pmc=484263 |doi= |url=}}</ref><ref name="pmid10700066">{{cite journal |author=Cohen DE, Strimike CL|title=A case of multiple spontaneous coronary artery dissections |journal=[[Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions]] |volume=49 |issue=3 |pages=318–20 |year=2000 |month=March |pmid=10700066 |doi= |url=}}</ref> Possible mechanisms underlying increased prevalence of SCAD in this population include: changes in the arterial wall media due to increasing hormone levels, shear stress during labor, fragmentation of reticulin fibers, loosening of ground substance, and hypertrophy of smooth muscle.<ref name="pmid19127318">{{cite journal |author=Van den Branden BJ, Bruggeling WA, Corbeij HM, Dunselman PH |title=Spontaneous coronary artery dissection in the postpartum period |journal=Neth Heart J |volume=16 |issue=12 |pages=412–4 |year=2008|month=December |pmid=19127318 |pmc=2612109 |doi= |url=}}</ref>

Revision as of 21:55, 1 December 2017

Spontaneous Coronary Artery Dissection Microchapters

Home

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Spontaneous coronary artery dissection from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Approach

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Angiography

CT

MRI

Echocardiography

Other Imaging Findings

Other Diagnostic Studies

Treatment

Treatment Approach

Medical Therapy

Percutaneous Coronary Intervention

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Type 1

Type 2A

Type 2B

Type 3

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nate Michalak, B.A.

Synonyms and keywords: SCAD

Overview

Epidemiology and Demographics

Prevalence

The true prevalence of spontaneous coronary artery dissection (SCAD) remains unknown and is estimated at 100 to 1,100 per 100,000 persons (0.1 to 1.1%) based on angiographic registries.[1]

Incidence

The incidence of SCAD is approximately 60 to 270 per 100,000 persons (0.06 to 0.27%).[2][3][4][5][6][7][8][9]

In the United States, there are approximately 800 new cases of SCAD occur every year.[10]

Case Fatality Rate

Age

Gender

SCAD has a strong predilection for young women with no or minimal traditional atherosclerotic risk factors. Studies indicate that SCAD accounts for approximately 25% of women aged < 50 who present with MI.[11]

Race






The left anterior descending artery (LAD) is the most commonly affected artery.[12][13] Although multivessel SCAD has been reported, single vessel SCAD is much more common. In women LAD is frequently involved[12] while in men right coronary artery is involved more often. Men tend to present at a slightly later age and also with evidence of CAD risk factors.

Observational studies have reported that SCAD is common among young women during their peripartum period[14] or in association with use of oral contraceptives. About 80% of SCAD cases reported so far have occurred in young women, especially those taking oral contraceptives (OCPs) or those in the peripartum period.[15][8][16] Possible mechanisms underlying increased prevalence of SCAD in this population include: changes in the arterial wall media due to increasing hormone levels, shear stress during labor, fragmentation of reticulin fibers, loosening of ground substance, and hypertrophy of smooth muscle.[17]

References

  1. ↑ Adams, Heath; Paratz, Elizabeth; Somaratne, Jithendra; Layland, Jamie; Burns, Andrew; Palmer, Sonny; MacIsaac, Andrew; Whitbourn, Robert (2017). "Different patients, different outcomes: A case-control study of spontaneous coronary artery dissection versus acute coronary syndrome". Journal of Interventional Cardiology. doi:10.1111/joic.12447. ISSN 0896-4327.
  2. ↑ Vanzetto, Gerald; Berger-Coz, Estelle; Barone-Rochette, Gilles; Chavanon, Olivier; Bouvaist, Helene; Hacini, Rachid; Blin, Dominique; Machecourt, Jacques (2009). "Prevalence, therapeutic management and medium-term prognosis of spontaneous coronary artery dissection: results from a database of 11,605 patients". European Journal of Cardio-Thoracic Surgery. 35 (2): 250–254. doi:10.1016/j.ejcts.2008.10.023. ISSN 1010-7940.
  3. ↑ Celik SK, Sagcan A, Altintig A, Yuksel M, Akin M, Kultursay H (2001). "Primary spontaneous coronary artery dissections in atherosclerotic patients. Report of nine cases with review of the pertinent literature". Eur J Cardiothorac Surg. 20 (3): 573–6. PMID 11509281.
  4. ↑ Alfonso, Fernando; Paulo, Manuel; Lennie, Vera; Dutary, Jaime; Bernardo, Esther; Jiménez-Quevedo, Pilar; Gonzalo, Nieves; Escaned, Javier; Bañuelos, Camino; Pérez-Vizcayno, María J.; Hernández, Rosana; Macaya, Carlos (2012). "Spontaneous Coronary Artery Dissection". JACC: Cardiovascular Interventions. 5 (10): 1062–1070. doi:10.1016/j.jcin.2012.06.014. ISSN 1936-8798.
  5. ↑ Mortensen, K.H.; Thuesen, L.; Kristensen, I.B.; Christiansen, E.H. (2009). "Spontaneous coronary artery dissection: A Western Denmark Heart Registry Study". Catheterization and Cardiovascular Interventions. 74 (5): 710–717. doi:10.1002/ccd.22115. ISSN 1522-1946.
  6. ↑ Pasalodos Pita J, Vazquez Gonzalez N, Perez Alvarez L, Vazquez Rodriguez JM, Castro Beiras A (1994). "Spontaneous coronary artery dissection". Cathet Cardiovasc Diagn. 32 (1): 27–32. PMID 8039214.
  7. ↑ Jorgensen MB, Aharonian V, Mansukhani P, Mahrer PR (1994). "Spontaneous coronary dissection: a cluster of cases with this rare finding". Am. Heart J. 127 (5): 1382–7. PMID 8172069.
  8. ↑ 8.0 8.1 Zampieri P, Aggio S, Roncon L, Rinuncini M, Canova C, Zanazzi G, Fiorencis R, Zonzin P (1996). "Follow up after spontaneous coronary artery dissection: a report of five cases". Heart. 75 (2): 206–9. PMC 484263. PMID 8673763.
  9. ↑ Hering D, Piper C, Hohmann C, Schultheiss HP, Horstkotte D (1998). "[Prospective study of the incidence, pathogenesis and therapy of spontaneous, by coronary angiography diagnosed coronary artery dissection]". Z Kardiol (in German). 87 (12): 961–70. PMID 10025069.
  10. ↑ Tweet, MS.; Hayes, SN.; Pitta, SR.; Simari, RD.; Lerman, A.; Lennon, RJ.; Gersh, BJ.; Khambatta, S.; Best, PJ. (2012). "Clinical features, management, and prognosis of spontaneous coronary artery dissection". Circulation. 126 (5): 579–88. doi:10.1161/CIRCULATIONAHA.112.105718. PMID 22800851. Unknown parameter |month= ignored (help)
  11. ↑ Saw J, Aymong E, Mancini GB, Sedlak T, Starovoytov A, Ricci D (2014). "Nonatherosclerotic coronary artery disease in young women". Can J Cardiol. 30 (7): 814–9. doi:10.1016/j.cjca.2014.01.011. PMID 24726091.
  12. ↑ 12.0 12.1 Vanzetto G, Berger-Coz E, Barone-Rochette G; et al. (2009). "Prevalence, therapeutic management and medium-term prognosis of spontaneous coronary artery dissection: results from a database of 11,605 patients". European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. 35 (2): 250–4. doi:10.1016/j.ejcts.2008.10.023. PMID 19046896. Unknown parameter |month= ignored (help)
  13. ↑ Kamran M, Guptan A, Bogal M (2008). "Spontaneous coronary artery dissection: case series and review". J Invasive Cardiol. 20 (10): 553–9. PMID 18830003. Unknown parameter |month= ignored (help)
  14. ↑ Fontanelli A, Olivari Z, La Vecchia L; et al. (2009). "Spontaneous dissections of coronary arteries and acute coronary syndromes: rationale and design of the DISCOVERY, a multicenter prospective registry with a case-control group". Journal of Cardiovascular Medicine (Hagerstown, Md.). 10 (1): 94–9. PMID 19708230. Unknown parameter |month= ignored (help)
  15. ↑ Narasimhan, S (2004). "Spontaneous coronary artery dissection (SCAD)" (PDF). IJTCVS. 20 (4): 189–91. doi:10.1007/s12055-004-0084-x.
  16. ↑ Cohen DE, Strimike CL (2000). "A case of multiple spontaneous coronary artery dissections". Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions. 49 (3): 318–20. PMID 10700066. Unknown parameter |month= ignored (help)
  17. ↑ Van den Branden BJ, Bruggeling WA, Corbeij HM, Dunselman PH (2008). "Spontaneous coronary artery dissection in the postpartum period". Neth Heart J. 16 (12): 412–4. PMC 2612109. PMID 19127318. Unknown parameter |month= ignored (help)
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