Spontaneous bacterial peritonitis other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Some emerging tests may provide a significant contribution to the diagnosis and therapeutic management of SBP although current laboratory diagnosis of SBP entail a limited number of conventional investigations, like ascitic fluid PMN count and culture.
Other Diagnostic Studies
Other emerging diagnostic tests used for the diagnosis of SBP include:
- The serum procalcitonin level has a 95% sensitivity, and 98% specificity with a 0.75 ng/mL cutoff.[1] Procalcitonin.[2][3]
- A value < 0.5 ng/ml rules out SBP.Highly sensitive.
- Assessment of Neutrophil gelatinase-associated lipocalin ( NGAL) in peritoneal fluid.[4][5]
- Amylase.
- C reactive protein.[2]
- Assessment of bacterial DNA in ascitic fluid by nucleic acid amplification.[6]
References
- ↑ Viallon A, Zeni F, Pouzet V, Lambert C, Quenet S, Aubert G; et al. (2000). "Serum and ascitic procalcitonin levels in cirrhotic patients with spontaneous bacterial peritonitis: diagnostic value and relationship to pro-inflammatory cytokines". Intensive Care Med. 26 (8): 1082–8. PMID 11030164.
- ↑ 2.0 2.1 Yuan, Le-Yong; Ke, Zun-Qiong; Wang, Ming; Li, Yan (2013). "Procalcitonin and C-Reactive Protein in the Diagnosis and Prediction of Spontaneous Bacterial Peritonitis Associated With Chronic Severe Hepatitis B". Annals of Laboratory Medicine. 33 (6): 449. doi:10.3343/alm.2013.33.6.449. ISSN 2234-3806.
- ↑ Su DH, Zhuo C, Liao K, Cheng WB, Cheng H, Zhao XF (2013). "Value of serum procalcitonin levels in predicting spontaneous bacterial peritonitis". Hepatogastroenterology. 60 (124): 641–6. doi:10.5754/hge12645. PMID 23159389.
- ↑ Lippi, Giuseppe; Caleffi, Alberta; Pipitone, Silvia; Elia, Gianfranco; Ngah, Anna; Aloe, Rosalia; Avanzini, Paola; Ferrari, Carlo (2013). "Assessment of neutrophil gelatinase-associated lipocalin and lactate dehydrogenase in peritoneal fluids for the screening of bacterial peritonitis". Clinica Chimica Acta. 418: 59–62. doi:10.1016/j.cca.2012.12.020. ISSN 0009-8981.
- ↑ Martino FK, Filippi I, Giavarina D, Kaushik M, Rodighiero MP, Crepaldi C; et al. (2012). "Neutrophil gelatinase-associated lipocalin in the early diagnosis of peritonitis: the case of neutrophil gelatinase-associated lipocalin". Contrib Nephrol. 178: 258–63. doi:10.1159/000337888. PMID 22652747.
- ↑ Hardick, J.; Won, H.; Jeng, K.; Hsieh, Y.-H.; Gaydos, C. A.; Rothman, R. E.; Yang, S. (2012). "Identification of Bacterial Pathogens in Ascitic Fluids from Patients with Suspected Spontaneous Bacterial Peritonitis by Use of Broad-Range PCR (16S PCR) Coupled with High-Resolution Melt Analysis". Journal of Clinical Microbiology. 50 (7): 2428–2432. doi:10.1128/JCM.00345-12. ISSN 0095-1137.