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==Overview==
==Overview==
Some emerging tests may provide a significant contribution to the diagnosis and therapeutic management of SBP although current laboratory diagnosis of SBP entail a limited number of conventional investigations, like ascitic fluid PMN count and culture.
Some emerging tests may provide a significant contribution to the diagnosis and therapeutic management of SBP although current laboratory diagnosis of SBP entail a limited number of conventional investigations, like ascitic fluid [[PMN|PMN count]] and [[Culture media|culture]].


==Other Diagnostic Studies==
==Other Diagnostic Studies==
Other emerging diagnostic tests used for the diagnosis of SBP include:
* The serum procalcitonin level has a 95% sensitivity, and 98% specificity with a 0.75 ng/mL cutoff.<ref name="pmid11030164">{{cite journal| author=Viallon A, Zeni F, Pouzet V, Lambert C, Quenet S, Aubert G et al.| title=Serum and ascitic procalcitonin levels in cirrhotic patients with spontaneous bacterial peritonitis: diagnostic value and relationship to pro-inflammatory cytokines. | journal=Intensive Care Med | year= 2000 | volume= 26 | issue= 8 | pages= 1082-8 | pmid=11030164 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11030164  }} </ref>  Procalcitonin.<ref name="YuanKe2013">{{cite journal|last1=Yuan|first1=Le-Yong|last2=Ke|first2=Zun-Qiong|last3=Wang|first3=Ming|last4=Li|first4=Yan|title=Procalcitonin and C-Reactive Protein in the Diagnosis and Prediction of Spontaneous Bacterial Peritonitis Associated With Chronic Severe Hepatitis B|journal=Annals of Laboratory Medicine|volume=33|issue=6|year=2013|pages=449|issn=2234-3806|doi=10.3343/alm.2013.33.6.449}}</ref><ref name="pmid23159389">{{cite journal| author=Su DH, Zhuo C, Liao K, Cheng WB, Cheng H, Zhao XF| title=Value of serum procalcitonin levels in predicting spontaneous bacterial peritonitis. | journal=Hepatogastroenterology | year= 2013 | volume= 60 | issue= 124 | pages= 641-6 | pmid=23159389 | doi=10.5754/hge12645 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23159389  }} </ref>
** A value < 0.5 ng/ml rules out SBP.Highly sensitive.
* Assessment of Neutrophil gelatinase-associated lipocalin ( NGAL) in peritoneal fluid.<ref name="LippiCaleffi2013">{{cite journal|last1=Lippi|first1=Giuseppe|last2=Caleffi|first2=Alberta|last3=Pipitone|first3=Silvia|last4=Elia|first4=Gianfranco|last5=Ngah|first5=Anna|last6=Aloe|first6=Rosalia|last7=Avanzini|first7=Paola|last8=Ferrari|first8=Carlo|title=Assessment of neutrophil gelatinase-associated lipocalin and lactate dehydrogenase in peritoneal fluids for the screening of bacterial peritonitis|journal=Clinica Chimica Acta|volume=418|year=2013|pages=59–62|issn=00098981|doi=10.1016/j.cca.2012.12.020}}</ref><ref name="pmid22652747">{{cite journal| author=Martino FK, Filippi I, Giavarina D, Kaushik M, Rodighiero MP, Crepaldi C et al.| title=Neutrophil gelatinase-associated lipocalin in the early diagnosis of peritonitis: the case of neutrophil gelatinase-associated lipocalin. | journal=Contrib Nephrol | year= 2012 | volume= 178 | issue=  | pages= 258-63 | pmid=22652747 | doi=10.1159/000337888 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22652747  }} </ref>
* Amylase.
* C reactive protein.<ref name="YuanKe2013">{{cite journal|last1=Yuan|first1=Le-Yong|last2=Ke|first2=Zun-Qiong|last3=Wang|first3=Ming|last4=Li|first4=Yan|title=Procalcitonin and C-Reactive Protein in the Diagnosis and Prediction of Spontaneous Bacterial Peritonitis Associated With Chronic Severe Hepatitis B|journal=Annals of Laboratory Medicine|volume=33|issue=6|year=2013|pages=449|issn=2234-3806|doi=10.3343/alm.2013.33.6.449}}</ref>
* Assessment of bacterial DNA in ascitic fluid by nucleic acid amplification.<ref name="HardickWon2012">{{cite journal|last1=Hardick|first1=J.|last2=Won|first2=H.|last3=Jeng|first3=K.|last4=Hsieh|first4=Y.-H.|last5=Gaydos|first5=C. A.|last6=Rothman|first6=R. E.|last7=Yang|first7=S.|title=Identification of Bacterial Pathogens in Ascitic Fluids from Patients with Suspected Spontaneous Bacterial Peritonitis by Use of Broad-Range PCR (16S PCR) Coupled with High-Resolution Melt Analysis|journal=Journal of Clinical Microbiology|volume=50|issue=7|year=2012|pages=2428–2432|issn=0095-1137|doi=10.1128/JCM.00345-12}}</ref>


Some emerging tests may provide a significant contribution to the diagnosis and therapeutic management of SBP although current laboratory diagnosis of SBP entail a limited number of conventional investigations, like ascitic fluid [[PMN|PMN count]] and [[Culture media|culture]].
==References==
==References==
{{reflist|2}}
{{reflist|2}}
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[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
[[Category:Hepatology]]
[[Category:Hepatology]]
[[Category:Emergency mdicine]]
[[Category:Disease]]
[[Category:Up-To-Date]]
[[Category:Infectious disease]]
[[Category:Infectious disease]]
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Latest revision as of 00:15, 30 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Younes M.B.B.CH [2]

Overview

Some emerging tests may provide a significant contribution to the diagnosis and therapeutic management of SBP although current laboratory diagnosis of SBP entail a limited number of conventional investigations, like ascitic fluid PMN count and culture.

Other Diagnostic Studies

Some emerging tests may provide a significant contribution to the diagnosis and therapeutic management of SBP although current laboratory diagnosis of SBP entail a limited number of conventional investigations, like ascitic fluid PMN count and culture.

References