Small cell carcinoma of the lung epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]; Rim Halaby, M.D. [3]
Overview
Small cell lung cancer (SCLC) represents 13.4% of all lung cancers in the Unites States. The majority of SCLC occurs among patients > 65 years of age. The age-adjusted incidence of SCLC in the United States is reported to be 6.23 per 100,000 in 2011.[1]
Epidemiology and Demographics
Incidence
- In the United States, the age adjusted incidence of small cell carcinoma is reported to be 8.94 per 100,000 between 1975 and 2011.
- The age adjusted incidence of SCLC in 1975: 6.64 per 100,000
- The age adjusted incidence of SCLC in 1998: 11.39 per 100,000
- The age adjusted incidence of SCLC in 2000: 8.80 per 100,000
- The age adjusted incidence of SCLC in 2011: 6.23 per 100,000[1]
- Small cell lung cancer accounts for 13.4% of all histologically confirmed cases of lung cancers.[1]
Stage Distribution
Among patients with small cell carcinoma, the percentages of the stages of the disease between 2004 and 2010 in the United States are:[1]
- Localized: 5%
- Regional: 21%
- Distant: 72%
- Unstaged: 3%
Age
- Most small cell lung cancer occur in patients > 65 years of age.
- While the overall age-adjusted incidence of SCLC in the United States between 2007 and 2011 is 7.2 per 100,000, the age-adjusted incidence of SCLC by age category is:[1]
- Under 65 years: 2.6 per 100,000
- 65 and over: 3.8 per 100,000
Gender
- In the past decade the male to female ratio of incidence of small cell lung cancer has decreased and the incidence per gender has come closer. The incidence of small cell lung cancer in different years is:[1]
- In 1975: 10.33 per 100,000 in males vs 3.79 per 100,000 in females
- In 2011: 6.81 per 100,000 in males vs 5.82 per 100,000 in females
- Shown below is an image depicting the incidence of small cell lung cancer by gender. Note the trend in the decrease in incidence of small cell lung cancer in males.[2]
Race
- Shown below is a table depicting the percentage of small cell lung cancer among patients with histologically confirmed lung cancer by race according to the SEER reports in 18 areas in the United States between 2007 and 2011.[1]
| Race | All Races | White | Black | Asian/Pacific Islander | American Indian/Alaska Native* | Hispanic |
| Percentage of small cell lung cancer | 13.4% | 14.1% | 10.5% | 7.9% | 18% | 11.5% |
| Adapted from SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD[1] *Estimates for American Indian/Alaska Native are based on the CHSDA (Contract Health Service Delivery Area) counties. | ||||||
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.
- ↑ NCCN Clinical Practice Guidelines in Oncology. Small Cell Lung Cancer, version 2.2014