Silicosis future or investigational therapies: Difference between revisions
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Esther Lee (talk | contribs) (Created page with "__NOTOC__ {{Silicosis}} {{CMG}} ==Overview== Silicosis is an irreversible condition with no cure. Treatment options currently focus on alleviating the symptoms and preventin...") |
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| quote = Previously it was shown that the action of tetrandrine is attributed to its ability to inhibit the release of reactive oxygen metabolites and inflammatory cytokines by alveolar macrophages, and that targeted delivery of tetrandrine to alveolar macrophages using a multiple emulsion system minimizes drug toxicity, maintains the drug's pharmacological activity, and enhances tetrandrine distribution in the lungs while reducing systemic drug distribution. This study provides ''in vivo'' evidence of emulsion-mediated enhancement of drug action in the lungs against silica-induced lung injury using a rat model. }}</ref> | | quote = Previously it was shown that the action of tetrandrine is attributed to its ability to inhibit the release of reactive oxygen metabolites and inflammatory cytokines by alveolar macrophages, and that targeted delivery of tetrandrine to alveolar macrophages using a multiple emulsion system minimizes drug toxicity, maintains the drug's pharmacological activity, and enhances tetrandrine distribution in the lungs while reducing systemic drug distribution. This study provides ''in vivo'' evidence of emulsion-mediated enhancement of drug action in the lungs against silica-induced lung injury using a rat model. }}</ref> | ||
==References== | ==References== | ||
Revision as of 19:27, 17 June 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Silicosis is an irreversible condition with no cure. Treatment options currently focus on alleviating the symptoms and preventing complications.
Future or Investigational Therapies
Experimental treatments include:
- Whole-lung lavage (see Bronchoalveolar lavage)
- Inhalation of powdered aluminium, d-penicillamine and polyvinyl pyridine-N-oxide.
- Corticosteroid therapy.
- The herbal extract tetrandine may slow progression of silicosis.[1]