Signaling lymphocytic activation molecule

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Signaling lymphocytic activation molecule is a family of genes. Homophilic binding between SLAMs is involved in cellular adhesion [1][2]

Signaling lymphocytic activation molecule (SLAM) is a CD2-related surface receptor expressed by activated T cells and B cells. SLAM is a self ligand and enhances T cellular proliferation and IFN-gamma production.

A defective SLAM associated protein (SAP) causes X-linked lymphoproliferative syndrome (XLP), a frequently lethal mononucleosis based on the inability to control EBV

Members of the family include:

References

  1. ↑ "SLAM FAMILY, MEMBER 1". OMIM. Retrieved 19 March 2014.
  2. ↑ Rosenbach, T; Csatò, M; Czarnetzki, B. M. (1988). "Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis". The British Journal of Dermatology. 118 (1): 1–6. doi:10.1111/j.1365-2133.1988.tb01743.x. PMID 2829957.
  3. ↑ Sintes, J; Engel, P (2011). "SLAM (CD150) is a multitasking immunoreceptor: From cosignalling to bacterial recognition". Immunology and cell biology. 89 (2): 161–3. doi:10.1038/icb.2010.145. PMID 21102539.
  4. ↑ Chatterjee, M.; Kis-Toth, K.; Thai, TH.; Terhorst, C.; Tsokos, GC. (May 2011). "SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells". Autoimmunity. 44 (3): 211–8. doi:10.3109/08916934.2010.530627. PMC 4465387. PMID 21231893.
  5. ↑ Kim, JR; Horton, NC; Mathew, SO; Mathew, PA (2013). "CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes". Inflammation Research. 62 (8): 765–72. doi:10.1007/s00011-013-0632-1. PMID 23695528.
  6. ↑ Wang, G; Abadía-Molina, AC; Berger, SB; Romero, X; O'Keeffe, MS; Rojas-Barros, DI; Aleman, M; Liao, G; et al. (2012). "Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages". Journal of Immunology. 188 (12): 5829–32. doi:10.4049/jimmunol.1102620. PMC 3370125. PMID 22593622.
  7. ↑ Pott, S.; Kamrani, N. K.; Bourque, G.; Pettersson, S.; Liu, E. T. (2012). Jothi, Raja, ed. "PPARG Binding Landscapes in Macrophages Suggest a Genome-Wide Contribution of PU.1 to Divergent PPARG Binding in Human and Mouse". PLoS ONE. 7 (10): e48102. doi:10.1371/journal.pone.0048102. PMC 3485280. PMID 23118933.


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