Signaling lymphocytic activation molecule: Difference between revisions

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'''Signaling lymphocytic activation molecule''' is a family of genes.  Homophilic binding between SLAMs is involved in cellular adhesion <ref>{{cite web|title=SLAM FAMILY, MEMBER 1|url=http://omim.org/entry/603492|publisher=OMIM|accessdate=19 March 2014}}</ref><ref>{{Cite journal
{{Pfam_box
| Symbol = SLAM
| Name = Signaling lymphocytic activation molecule
| image =
| width =
| caption =
| InterPro= IPR010407
| PROSITE =
| SCOP =
| TCDB =
| OPM family=
| OPM protein=
| Pfam= PF06214
| PDB=
| Membranome family= 164
}}


  | pmid = 2829957
'''Signaling lymphocytic activation molecule''' is a family of genes. Homophilic binding between SLAMs is involved in cellular adhesion <ref>{{cite web|title=SLAM FAMILY, MEMBER 1|url=http://omim.org/entry/603492|publisher=OMIM|access-date=19 March 2014}}</ref><ref>{{cite journal | vauthors = Rosenbach T, Csatò M, Czarnetzki BM | title = Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis | journal = The British Journal of Dermatology | volume = 118 | issue = 1 | pages = 1–6 | date = January 1988 | pmid = 2829957 | doi = 10.1111/j.1365-2133.1988.tb01743.x }}</ref>
| year = 1988
| author1 = Rosenbach
| first1 = T
| title = Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis
| journal = The British Journal of Dermatology
| volume = 118
| issue = 1
| pages = 1–6
| last2 = Csatò
| first2 = M
| last3 = Czarnetzki
| first3 = B. M.
| doi=10.1111/j.1365-2133.1988.tb01743.x
}}</ref>


Signaling lymphocytic activation molecule (SLAM) is a CD2-related surface receptor expressed by activated T cells and B cells. SLAM is a self ligand and enhances T cellular proliferation and IFN-gamma production.
Signaling lymphocytic activation molecule (SLAM) is a CD2-related surface receptor expressed by activated T cells and B cells. SLAM is a self ligand and enhances T cellular proliferation and IFN-gamma production.
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* [[SLAMF1]] (CD150)
* [[SLAMF1]] (CD150)
* [[SLAMF2]] (CD48)<ref>{{cite journal|pmid=21102539|year=2011|last1=Sintes|first1=J|last2=Engel|first2=P|title=SLAM (CD150) is a multitasking immunoreceptor: From cosignalling to bacterial recognition|volume=89|issue=2|pages=161–3|doi=10.1038/icb.2010.145|journal=Immunology and cell biology}}</ref>
* [[SLAMF2]] (CD48)<ref>{{cite journal | vauthors = Sintes J, Engel P | title = SLAM (CD150) is a multitasking immunoreceptor: from cosignalling to bacterial recognition | journal = Immunology and Cell Biology | volume = 89 | issue = 2 | pages = 161–3 | date = February 2011 | pmid = 21102539 | doi = 10.1038/icb.2010.145 }}</ref>
* [[SLAMF3]] (CD229, LY9)
* [[SLAMF3]] (CD229, LY9)
* [[SLAMF4]] (CD244)
* [[SLAMF4]] (CD244)
* [[SLAMF5]] (CD84)
* [[SLAMF5]] (CD84)
* [[SLAMF6]] (CD352)<ref>{{Cite journal | last1 = Chatterjee | first1 = M. | last2 = Kis-Toth | first2 = K. | last3 = Thai | first3 = TH. | last4 = Terhorst | first4 = C. | last5 = Tsokos | first5 = GC. | title = SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells. | journal = Autoimmunity | volume = 44 | issue = 3 | pages = 211–8 |date=May 2011 | doi = 10.3109/08916934.2010.530627 | pmid = 21231893 | pmc=4465387}}
* [[SLAMF6]] (CD352)<ref>{{cite journal | vauthors = Chatterjee M, Kis-Toth K, Thai TH, Terhorst C, Tsokos GC | title = SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells | journal = Autoimmunity | volume = 44 | issue = 3 | pages = 211–8 | date = May 2011 | pmid = 21231893 | pmc = 4465387 | doi = 10.3109/08916934.2010.530627 }}
</ref>
</ref>
* [[SLAMF7]] (CD319)<ref>{{cite journal|pmid=23695528|year=2013|last1=Kim|first1=JR|last2=Horton|first2=NC|last3=Mathew|first3=SO|last4=Mathew|first4=PA|title=CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes|volume=62|issue=8|pages=765–72|doi=10.1007/s00011-013-0632-1|journal=Inflammation Research}}</ref>
* [[SLAMF7]] (CD319)<ref>{{cite journal | vauthors = Kim JR, Horton NC, Mathew SO, Mathew PA | title = CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes | journal = Inflammation Research | volume = 62 | issue = 8 | pages = 765–72 | date = August 2013 | pmid = 23695528 | doi = 10.1007/s00011-013-0632-1 }}</ref>
* [[SLAMF8]] (CD353)<ref>{{cite journal|pmid=22593622|year=2012|last1=Wang|first1=G|last2=Abadía-Molina|first2=AC|last3=Berger|first3=SB|last4=Romero|first4=X|last5=O'Keeffe|first5=MS|last6=Rojas-Barros|first6=DI|last7=Aleman|first7=M|last8=Liao|first8=G|last9=Maganto-García|first9=E|last10=Fresno|first10=M.|last11=Wang|first11=N.|last12=Detre|first12=C.|last13=Terhorst|first13=C.|title=Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages|volume=188|issue=12|pages=5829–32|doi=10.4049/jimmunol.1102620|pmc=3370125|journal=Journal of Immunology|display-authors=8}}</ref>
* [[SLAMF8]] (CD353)<ref>{{cite journal | vauthors = Wang G, Abadía-Molina AC, Berger SB, Romero X, O'Keeffe MS, Rojas-Barros DI, Aleman M, Liao G, Maganto-García E, Fresno M, Wang N, Detre C, Terhorst C | title = Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages | journal = Journal of Immunology | volume = 188 | issue = 12 | pages = 5829–32 | date = June 2012 | pmid = 22593622 | pmc = 3370125 | doi = 10.4049/jimmunol.1102620 }}</ref>
* [[SLAMF9]]<ref>{{Cite journal | last1 = Pott | first1 = S. | last2 = Kamrani | first2 = N. K. | last3 = Bourque | first3 = G. | last4 = Pettersson | first4 = S. | last5 = Liu | first5 = E. T. | editor1-last = Jothi | editor1-first = Raja | title = PPARG Binding Landscapes in Macrophages Suggest a Genome-Wide Contribution of PU.1 to Divergent PPARG Binding in Human and Mouse | doi = 10.1371/journal.pone.0048102 | journal = PLoS ONE | volume = 7 | issue = 10 | pages = e48102 | year = 2012 | pmid = 23118933| pmc =3485280 }}</ref>
* [[SLAMF9]]<ref>{{cite journal | vauthors = Pott S, Kamrani NK, Bourque G, Pettersson S, Liu ET | title = PPARG binding landscapes in macrophages suggest a genome-wide contribution of PU.1 to divergent PPARG binding in human and mouse | journal = PLOS One | volume = 7 | issue = 10 | pages = e48102 | year = 2012 | pmid = 23118933 | pmc = 3485280 | doi = 10.1371/journal.pone.0048102 | editor1-last = Jothi | editor1-first = Raja }}</ref>


==References==
== References ==
{{reflist}}
{{reflist}}
{{Clear}}
{{Clear}}


[[Category:Genes on human chromosome 1]]
[[Category:Genes on human chromosome 1]]
[[Category:Single-pass transmembrane proteins]]




{{Biochem-stub}}
{{Biochem-stub}}
{{immunology-stub}}
{{immunology-stub}}

Latest revision as of 23:37, 13 August 2018

Signaling lymphocytic activation molecule
Identifiers
SymbolSLAM
PfamPF06214
InterProIPR010407
Membranome164

Signaling lymphocytic activation molecule is a family of genes. Homophilic binding between SLAMs is involved in cellular adhesion [1][2]

Signaling lymphocytic activation molecule (SLAM) is a CD2-related surface receptor expressed by activated T cells and B cells. SLAM is a self ligand and enhances T cellular proliferation and IFN-gamma production.

A defective SLAM associated protein (SAP) causes X-linked lymphoproliferative syndrome (XLP), a frequently lethal mononucleosis based on the inability to control EBV

Members of the family include:

References

  1. ↑ "SLAM FAMILY, MEMBER 1". OMIM. Retrieved 19 March 2014.
  2. ↑ Rosenbach T, Csatò M, Czarnetzki BM (January 1988). "Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis". The British Journal of Dermatology. 118 (1): 1–6. doi:10.1111/j.1365-2133.1988.tb01743.x. PMID 2829957.
  3. ↑ Sintes J, Engel P (February 2011). "SLAM (CD150) is a multitasking immunoreceptor: from cosignalling to bacterial recognition". Immunology and Cell Biology. 89 (2): 161–3. doi:10.1038/icb.2010.145. PMID 21102539.
  4. ↑ Chatterjee M, Kis-Toth K, Thai TH, Terhorst C, Tsokos GC (May 2011). "SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells". Autoimmunity. 44 (3): 211–8. doi:10.3109/08916934.2010.530627. PMC 4465387. PMID 21231893.
  5. ↑ Kim JR, Horton NC, Mathew SO, Mathew PA (August 2013). "CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes". Inflammation Research. 62 (8): 765–72. doi:10.1007/s00011-013-0632-1. PMID 23695528.
  6. ↑ Wang G, Abadía-Molina AC, Berger SB, Romero X, O'Keeffe MS, Rojas-Barros DI, Aleman M, Liao G, Maganto-García E, Fresno M, Wang N, Detre C, Terhorst C (June 2012). "Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages". Journal of Immunology. 188 (12): 5829–32. doi:10.4049/jimmunol.1102620. PMC 3370125. PMID 22593622.
  7. ↑ Pott S, Kamrani NK, Bourque G, Pettersson S, Liu ET (2012). Jothi R, ed. "PPARG binding landscapes in macrophages suggest a genome-wide contribution of PU.1 to divergent PPARG binding in human and mouse". PLOS One. 7 (10): e48102. doi:10.1371/journal.pone.0048102. PMC 3485280. PMID 23118933.


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