Short QT syndrome diagnostic criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Recent diagnostic criteria have been published out of the Arrhythmia Research Laboratory at the University of Ottawa Heart Institute from Drs. Michael H Gollob and Jason D Roberts.[1]

The Short QT Syndrome diagnostic criteria is based on a point system as follows:

  • QTc in milliseconds
<370 = 1 point
<350 = 2 points
<330 = 3 points
  • J point - T peak interval in milliseconds
<120 = 1 point
  • Clinical History
Sudden cardiac arrest = 2 points
Polymorphic VT or VF = 2 points
Unexplained syncope = 1 point
Atrial fibrillation = 1 point
  • Family History
1st or 2nd degree relative with SQTS = 2 points
1st or 2nd degree relative with sudden death = 1 point
Sudden infant death syndrome = 1 point
  • Genotype
Genotype positive = 2 points
Mutation of undetermined significance in a culprit gene = 1 point

The points are summed and interpreted as follows:

  • > or equal to 4 points: High-probability of SQTS
  • 3 Points: Intermediate probability of SQTS
  • 2 points or less: Low probability of SQTS

References

  1. Gollob M, Redpath C, Roberts J. (2011). "The Short QT syndrome: Proposed Diagnostic Criteria". J Am Coll Cardiol. 57 (7): 802–812. doi:10.1016/j.jacc.2010.09.048. PMID 21310316.