Sexcord/ stromal ovarian tumors laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  ; Maneesha Nandimandalam, M.B.B.S.[2]

Overview

Laboratory findings consistent with the diagnosis of sexcord/ stromal ovarian tumors include identifying the presence or absence of tumor markers like AMH: anti-Müllerian hormone; AFP: alpha-fetoprotein; E2: estradiol; hCG: human chorionic gonadotropin; LDH: lactate dehydrogenase; testost: testosterone; andro: androstenedione; DHEA: dehydroepiandrostenedione;

Laboratory Findings

Sex cord-stromal tumors AFP hCG LDH E2 Inhibin Testosterone Androstenedione DHEA AMH
Thecoma-fibroma - - - - - - - - -
Granulosa cell tumors - - - +/- + +/- - - +
Sertoli-Leydig tumors +/- - - +/- +/- +/- +/- +/- -

AMH: anti-Müllerian hormone; AFP: alpha-fetoprotein; E2: estradiol; hCG: human chorionic gonadotropin; LDH: lactate dehydrogenase; testost: testosterone; andro: androstenedione; DHEA: dehydroepiandrostenedione; .

References

  1. Rey RA, Lhommé C, Marcillac I, Lahlou N, Duvillard P, Josso N, Bidart JM (March 1996). "Antimüllerian hormone as a serum marker of granulosa cell tumorsof the ovary: comparative study with serum alpha-inhibin and estradiol". Am. J. Obstet. Gynecol. 174 (3): 958–65. PMID 8633676.
  2. Robertson DM, Cahir N, Burger HG, Mamers P, Groome N (March 1999). "Inhibin forms in serum from postmenopausal women with ovarian cancers". Clin. Endocrinol. (Oxf). 50 (3): 381–6. PMID 10435065.
  3. Robertson DM, Stephenson T, Pruysers E, Burger HG, McCloud P, Tsigos A, Groome N, Mamers P, McNeilage J, Jobling T, Healy D (May 2002). "Inhibins/activins as diagnostic markers for ovarian cancer". Mol. Cell. Endocrinol. 191 (1): 97–103. PMID 12044923.
  4. Markova D, Milchev N, Batashki I, Uchikov A (2008). "[Role of total inhibin in diagnosis and monitoring of ovarian cancer in postmenopausal women]". Akush Ginekol (Sofiia) (in Bulgarian). 47 (1): 16–9. PMID 18642569.
  5. Robertson DM, Stephenson T, Pruysers E, McCloud P, Tsigos A, Groome N, Mamers P, Burger HG (February 2002). "Characterization of inhibin forms and their measurement by an inhibin alpha-subunit ELISA in serum from postmenopausal women with ovarian cancer". J. Clin. Endocrinol. Metab. 87 (2): 816–24. doi:10.1210/jcem.87.2.8198. PMID 11836327.
  6. Kurihara S, Hirakawa T, Amada S, Ariyoshi K, Nakano H (December 2004). "Inhibin-producing ovarian granulosa cell tumor as a cause of secondary amenorrhea: case report and review of the literature". J. Obstet. Gynaecol. Res. 30 (6): 439–43. doi:10.1111/j.1447-0756.2004.00231.x. PMID 15566459.
  7. Ran S, Yu Q, Deng S, Xu L (April 2017). "Luteinizing hormone elevation in ovarian granulosa cell tumor: a case report and review of the literature". J Ovarian Res. 10 (1): 30. doi:10.1186/s13048-017-0327-2. PMC 5404692. PMID 28438188.
  8. Bufa A, Farkas N, Preisz Z, Poór V, Páger C, Szukits S, Farkas B, Gőcze PM (June 2017). "Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports". J Med Case Rep. 11 (1): 166. doi:10.1186/s13256-017-1324-1. PMC 5480180. PMID 28637499.

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