Senile plaques

Revision as of 15:58, 20 August 2012 by WikiBot (talk | contribs) (Robot: Automated text replacement (-{{SIB}} +, -{{EH}} +, -{{EJ}} +, -{{Editor Help}} +, -{{Editor Join}} +))
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

WikiDoc Resources for Senile plaques


Most recent articles on Senile plaques

Most cited articles on Senile plaques

Review articles on Senile plaques

Articles on Senile plaques in N Eng J Med, Lancet, BMJ


Powerpoint slides on Senile plaques

Images of Senile plaques

Photos of Senile plaques

Podcasts & MP3s on Senile plaques

Videos on Senile plaques

Evidence Based Medicine

Cochrane Collaboration on Senile plaques

Bandolier on Senile plaques

TRIP on Senile plaques

Clinical Trials

Ongoing Trials on Senile plaques at Clinical

Trial results on Senile plaques

Clinical Trials on Senile plaques at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Senile plaques

NICE Guidance on Senile plaques


FDA on Senile plaques

CDC on Senile plaques


Books on Senile plaques


Senile plaques in the news

Be alerted to news on Senile plaques

News trends on Senile plaques


Blogs on Senile plaques


Definitions of Senile plaques

Patient Resources / Community

Patient resources on Senile plaques

Discussion groups on Senile plaques

Patient Handouts on Senile plaques

Directions to Hospitals Treating Senile plaques

Risk calculators and risk factors for Senile plaques

Healthcare Provider Resources

Symptoms of Senile plaques

Causes & Risk Factors for Senile plaques

Diagnostic studies for Senile plaques

Treatment of Senile plaques

Continuing Medical Education (CME)

CME Programs on Senile plaques


Senile plaques en Espanol

Senile plaques en Francais


Senile plaques in the Marketplace

Patents on Senile plaques

Experimental / Informatics

List of terms related to Senile plaques

Senile plaques (syn. neuritic plaques, senile druse, braindruse) are extracellular deposits of amyloid in the gray matter of the brain. The deposits are associated with degenerative neural structures and an abundance of microglia and astrocytes. Large numbers of senile plaques and neurofibrillary tangles are characteristic features of Alzheimer’s disease.

senile plaques (silver impregnation)

The plaques are variable in shape and size, but are on the average 50 µm in size. (Franke, M.) In Alzheimer's disease they are primarily composed of amyloid beta peptides. These polypetides tend to aggregate and are believed to be neurotoxic.


Senile plaques are visible in light microscopy after staining by silver, Congo red, Thioflavin, Kresylviolett, PAS-reaction, and by fluorescence and immunofluorescence microscopy.


Senile plaques can be found in human and animal brains (e.g. mammals and birds). From an age of 60 years (10%) to an age of 80 years (60%) the proportion of people with plaques increases approximately linearly. A small number of plaques can be due to the physiological process of aging. Women are slightly more likely to have plaques than males (Franke, M.). The plaques occur commonly in the amygdoid nucleus and the sulci of the cortex of brain.


Blocq and Marinesco first described plaques in the grey matter in 1892. Because of their similarity to the actinomyces druses they were called druse necrosis by O. Fischer in the beginning of the 20th century. The connection of plaques and demential illness was discovered by Alzheimer in 1906. Bielschowsky supposed in 1911 the amyloid-nature of the plaques. Wisniewski denominated them neuritic plaques in 1973. The second half of the 20th century saw proposed theories of immunological and genetic factors in plaque formation (Katenkamp, Op den Velde und Stam). Statistically investigations were performed by J.A.N. Corsellis and M. Franke in the 1970s. M. Franke showed that a demential disease is likely when the number of senile plaques in the frontal cortex is more than 200/mm3. In 1985 succeeded the biochemical identification of amyloid beta. But there are more unsolved questions of formation and importance of the plaque formation.


The senile plaques are an important criterion of the neuropathological-histological verification of the Alzheimer’s disease; other factors in verification include pathological neurofibrillaries, tangles, atrophic brain with hydrocephalus, and other degenerative signs. The formation and the distribution of the pathological neurofibrillaries have a regularity (H. Braak and E. Braak) and allows to stage the disease. In combination with the occurrence of a great number of plaques the Alzheimer’s disease can diagnosed with high probability.


  • FRANKE, MANFRED: Statistische Untersuchungen über die senilen Drusen im menschlichen Gehirn (zum Problem der Hirndrusenkrankheit). Statistical investigation of the senile plaques in human brains - 1975. Berlin, Akad. für Ärztl. Fortbildung d. DDR, Diss. B, 1976. Deutsche Nationalbiografie Signatur: DBF H 76/10016, IDN: 801313783 Thesen zur Dissertation
  • BRAAK, H., E. BRAAK, J. BOHL: Staging of Alzheimer-related cortical destruction. European Neurology, Basel, 1993, 33: 403-408.
  • JELLINGER, K.A.: Neurodegenerative Erkrankungen (ZNS) - Eine aktuelle Übersicht. Journal für Neurologie, Neurochirurgie und Psychiatrie 2005; 6 (1), 9-18
  • CRUZ, L.; B. URBANC: Aggregation and disaggregation of senile plaques in Alzheimer disease. Proc. Natl. Acad. Sci. USA Vol. 94, pp. 7612±7616, July 1997 Neurobiology

Template:WikiDoc Sources