Seminoma causes: Difference between revisions
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===Common Causes=== | ===Common Causes=== | ||
Common causes of | Common causes of seminoma may include:<ref name="pmid23519268">{{cite journal |vauthors=Ferguson L, Agoulnik AI |title=Testicular cancer and cryptorchidism |journal=Front Endocrinol (Lausanne) |volume=4 |issue= |pages=32 |date=2013 |pmid=23519268 |doi=10.3389/fendo.2013.00032 |url=}}</ref> | ||
*Cryptorchidism | |||
*Undescended testis | |||
*Abdominal testis | |||
*Trauma | |||
*Mumps | |||
*Maternal estrogen exposure | |||
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===Genetic Causes=== | ===Genetic Causes=== | ||
* | *Seminoma is caused by a mutation in the KIT gene.<ref name="pmid17943970">{{cite journal |vauthors=Coffey J, Linger R, Pugh J, Dudakia D, Sokal M, Easton DF, Timothy Bishop D, Stratton M, Huddart R, Rapley EA |title=Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature |journal=Genes Chromosomes Cancer |volume=47 |issue=1 |pages=34–42 |date=January 2008 |pmid=17943970 |doi=10.1002/gcc.20503 |url=}}</ref> | ||
*12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases.<ref name="pmid27584029">{{cite journal |vauthors=Woldu SL, Amatruda JF, Bagrodia A |title=Testicular germ cell tumor genomics |journal=Curr Opin Urol |volume=27 |issue=1 |pages=41–47 |date=January 2017 |pmid=27584029 |pmc=6368344 |doi=10.1097/MOU.0000000000000347 |url=}}</ref> | |||
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Revision as of 13:00, 15 May 2019
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Seminoma Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Disease name] may be caused by [cause1], [cause2], or [cause3].
OR
Common causes of [disease] include [cause1], [cause2], and [cause3].
OR
The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
OR
The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.
Causes
Life-threatening Causes
- Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of disease name, however complications resulting from untreated disease name is common.
- Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
- [Cause] is a life-threatening cause of [disease].
Common Causes
Common causes of seminoma may include:[1]
- Cryptorchidism
- Undescended testis
- Abdominal testis
- Trauma
- Mumps
- Maternal estrogen exposure
Genetic Causes
- Seminoma is caused by a mutation in the KIT gene.[2]
- 12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases.[3]
References
- ↑ Ferguson L, Agoulnik AI (2013). "Testicular cancer and cryptorchidism". Front Endocrinol (Lausanne). 4: 32. doi:10.3389/fendo.2013.00032. PMID 23519268.
- ↑ Coffey J, Linger R, Pugh J, Dudakia D, Sokal M, Easton DF, Timothy Bishop D, Stratton M, Huddart R, Rapley EA (January 2008). "Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature". Genes Chromosomes Cancer. 47 (1): 34–42. doi:10.1002/gcc.20503. PMID 17943970.
- ↑ Woldu SL, Amatruda JF, Bagrodia A (January 2017). "Testicular germ cell tumor genomics". Curr Opin Urol. 27 (1): 41–47. doi:10.1097/MOU.0000000000000347. PMC 6368344. PMID 27584029.