Difference between revisions of "Secondary amyloidosis other diagnostic studies"

Jump to: navigation, search
(Created page with "__NOTOC__ {{Secondary amyloidosis}} {{CMG}} {{AE}} {{SHH}} ==Overview== A tissue biopsy or fat aspirate should be done to confirm the presence or type of amyloid...")
 
 
Line 8: Line 8:
 
==Other Diagnostic Studies==
 
==Other Diagnostic Studies==
 
*  A tissue [[biopsy]] or fat [[aspirate]] should be done to confirm the presence or type of [[amyloid]] protein which is involved in the [[pathogenesis]] of the disease.<ref name="pmid24497558">{{cite journal |vauthors=Mahmood S, Palladini G, Sanchorawala V, Wechalekar A |title=Update on treatment of light chain amyloidosis |journal=Haematologica |volume=99 |issue=2 |pages=209–21 |date=February 2014 |pmid=24497558 |pmc=3912950 |doi=10.3324/haematol.2013.087619 |url=}}</ref>
 
*  A tissue [[biopsy]] or fat [[aspirate]] should be done to confirm the presence or type of [[amyloid]] protein which is involved in the [[pathogenesis]] of the disease.<ref name="pmid24497558">{{cite journal |vauthors=Mahmood S, Palladini G, Sanchorawala V, Wechalekar A |title=Update on treatment of light chain amyloidosis |journal=Haematologica |volume=99 |issue=2 |pages=209–21 |date=February 2014 |pmid=24497558 |pmc=3912950 |doi=10.3324/haematol.2013.087619 |url=}}</ref>
 
+
* To obtain a sample for histologic examination, multiple anatomical places have been used so far.
 +
* In 1960s, gingival and mucosa biopsy were the anatomic places of choice, but they were now replaced by other more accessible places.
 +
* Table below compares the recommended anatomical places.<ref name="Real de AsuaGalvan2014">{{cite journal|last1=Real de Asua|first1=Diego|last2=Galvan|first2=Jose Maria|last3=Filigghedu|first3=Maria Teresa|last4=Trujillo|first4=Davinia|last5=Costa|first5=Ramon|last6=Cadinanos|first6=Julen|title=Systemic AA amyloidosis: epidemiology, diagnosis, and management|journal=Clinical Epidemiology|year=2014|pages=369|issn=1179-1349|doi=10.2147/CLEP.S39981}}</ref>
 +
* It is of particular note that, a negative biopsy result for amyloid deposition would not exclude the diagnosis of amyloidosis, especially in the presence of high clinical suspicion.
 +
{|
 +
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
 +
! style="background: #4479BA; color: #FFFFFF; text-align: center;" | Test
 +
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Sensitivity
 +
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Specificity
 +
|-
 +
! style="background: #696969; color: #FFFFFF; text-align: center;" |Subcutaneous abdominal fat tissue aspiration
 +
| style="background: #DCDCDC; padding: 5px; text-align: center;" |57%–82%
 +
| style="background: #DCDCDC; padding: 5px; text-align: center;" |93%–100%
 +
|-
 +
! style="background: #696969; color: #FFFFFF; text-align: center;" |Rectal mucosa biopsy
 +
| style="background: #DCDCDC; padding: 5px; text-align: center;" |75%–85%
 +
| style="background: #DCDCDC; padding: 5px; text-align: center;" |_
 +
|-
 +
! style="background: #696969; color: #FFFFFF; text-align: center;" |Minor salivary gland biopsy
 +
| style="background: #DCDCDC; padding: 5px; text-align: center;" |83%–100%
 +
| style="background: #DCDCDC; padding: 5px; text-align: center;" |_
 +
|}
 
==References==
 
==References==
 
{{reflist|2}}
 
{{reflist|2}}

Latest revision as of 22:38, 10 November 2019

Secondary amyloidosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Secondary amyloidosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Secondary amyloidosis other diagnostic studies On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Secondary amyloidosis other diagnostic studies

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Secondary amyloidosis other diagnostic studies

CDC on Secondary amyloidosis other diagnostic studies

Secondary amyloidosis other diagnostic studies in the news

Blogs on Secondary amyloidosis other diagnostic studies

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Secondary amyloidosis other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Overview

A tissue biopsy or fat aspirate should be done to confirm the presence or type of amyloid protein which is involved in the pathogenesis of the disease.

Other Diagnostic Studies

  •  A tissue biopsy or fat aspirate should be done to confirm the presence or type of amyloid protein which is involved in the pathogenesis of the disease.[1]
  • To obtain a sample for histologic examination, multiple anatomical places have been used so far.
  • In 1960s, gingival and mucosa biopsy were the anatomic places of choice, but they were now replaced by other more accessible places.
  • Table below compares the recommended anatomical places.[2]
  • It is of particular note that, a negative biopsy result for amyloid deposition would not exclude the diagnosis of amyloidosis, especially in the presence of high clinical suspicion.
Test Sensitivity Specificity
Subcutaneous abdominal fat tissue aspiration 57%–82% 93%–100%
Rectal mucosa biopsy 75%–85% _
Minor salivary gland biopsy 83%–100% _

References

  1. Mahmood S, Palladini G, Sanchorawala V, Wechalekar A (February 2014). "Update on treatment of light chain amyloidosis". Haematologica. 99 (2): 209–21. doi:10.3324/haematol.2013.087619. PMC 3912950. PMID 24497558.
  2. Real de Asua, Diego; Galvan, Jose Maria; Filigghedu, Maria Teresa; Trujillo, Davinia; Costa, Ramon; Cadinanos, Julen (2014). "Systemic AA amyloidosis: epidemiology, diagnosis, and management". Clinical Epidemiology: 369. doi:10.2147/CLEP.S39981. ISSN 1179-1349.



Linked-in.jpg