Sarcomatoid carcinoma of the lung: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{SI}} | |||
{{Sarcomatoid carcinoma of the lung | {{CMG}} {{AE}} {{MV}} | ||
{{ | |||
{{SK}} Synonym 1; Synonym 2; Synonym 3 | |||
==Overview== | |||
Sarcomatoid carcinoma of the lung is a rare histologic subtype of non-small cell lung cancer. Sarcomatoid carcinoma of the lung is a "sarcoma-like" carcinoma neoplasm. The overall prevalence of sarcomatoid carcinoma of the lung is 0.1% to 0.4% of all lung malignancies.<ref name="pmid20073605">{{cite journal |vauthors=Franks TJ, Galvin JR |title=Sarcomatoid carcinoma of the lung: histologic criteria and common lesions in the differential diagnosis |journal=Arch. Pathol. Lab. Med. |volume=134 |issue=1 |pages=49–54 |year=2010 |pmid=20073605 |doi=10.1043/2008-0547-RAR.1 |url=}}</ref> | |||
== | ==Historical Perspective== | ||
*In 1988, EGFR gene mutations were first identified in the pathogenesis of sarcomatoid carcinoma of the lung. | |||
== | ==Classification== | ||
*Sarcomatoid carcinoma of the lung may be classified according to WHO classification into 5 subtypes: | |||
:*Pleomorphic carcinoma | |||
:*Spindle cell carcinoma | |||
:*Giant cell carcinoma | |||
:*Carcinosarcoma | |||
:*Pulmonary blastoma | |||
*Other variants of sarcomatoid carcinoma of the lung is primary lung sarcoma. | |||
==Pathophysiology== | |||
*The pathogenesis of sarcomatoid carcinoma of the lung is characterized by a rare epithelial origin, and morphologic features suggestive of a malignant mesenchymal tumour. | |||
*Sarcomatoid carcinoma of the lung arises from epithelial cells but has morphologic features suggestive of a malignant mesenchymal tumour It is a sarcoma-like carcinoma. | |||
*The EGFR gene and K-ras mutations mutation has been associated with the development of sarcomatoid carcinoma of the lung. | |||
*On gross pathology, a large size, mass lesion, upper lobe and peripheral located are characteristic findings of sarcomatoid carcinoma of the lung. | |||
*On microscopic histopathological analysis, sarcomatous components are characteristic findings of sarcomatoid carcinoma of the lung. | |||
==Causes== | |||
== | * Sarcomatoid carcinoma of the lung may be caused by a mutation in the EGFR and K-ras genes. | ||
==Differentiating sarcomatoid carcinoma of the lung from other Diseases== | |||
== | *Sarcomatoid carcinoma of the lung must be differentiated from other diseases that cause cough, weight loss, hemoptysis, and dyspnea among adults, such as: | ||
:*Tuberculosis | |||
:*Adenocarcinoma of the lung | |||
:*Pulmonary fungal disease | |||
:*Lung abscess | |||
==Epidemiology and Demographics== | |||
* The prevalence of sarcomatoid carcinoma of the lung is approximately 0.4 cases per 100,000 individuals worldwide. | |||
*The overall prevalence of sarcomatoid carcinoma of the lung is 0.1% to 0.4% of all lung malignancies.<ref name="pmid20073605">{{cite journal |vauthors=Franks TJ, Galvin JR |title=Sarcomatoid carcinoma of the lung: histologic criteria and common lesions in the differential diagnosis |journal=Arch. Pathol. Lab. Med. |volume=134 |issue=1 |pages=49–54 |year=2010 |pmid=20073605 |doi=10.1043/2008-0547-RAR.1 |url=}}</ref> | |||
== | |||
===Age=== | |||
* Sarcomatoid carcinoma of the lung is more commonly observed among patients aged 50 to 75 years old. | |||
* Sarcomatoid carcinoma of the lung is more commonly observed among elderly patients and adults | |||
===Gender=== | |||
*Males are more commonly affected with sarcomatoid carcinoma of the lung than [gender 2]. | |||
==[[ | ===Race=== | ||
*There is no racial predilection for sarcomatoid carcinoma of the lung. | |||
*[Disease name] usually affects individuals of the [race 1] race. | |||
*[Race 2] individuals are less likely to develop sarcomatoid carcinoma of the lung. | |||
==Risk Factors== | |||
*Common risk factors in the development of sarcomatoid carcinoma of the lung are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4]. | |||
== Natural History, Complications and Prognosis== | |||
*The majority of patients with sarcomatoid carcinoma of the lung remain asymptomatic for [duration/years]. | |||
*Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3]. | |||
*If left untreated, [#%] of patients with sarcomatoid carcinoma of the lung may progress to develop lymphatic invasion, distant metastasis, and | |||
*Common complications of sarcomatoid carcinoma of the lung include respiratory failure, pneumonia, and distant metastasis. | |||
*Prognosis is generally poor, and the average 5- survival rate of patients with sarcomatoid carcinoma of the lung is approximately [#%]. | |||
== Diagnosis == | |||
===Diagnostic Criteria=== | |||
*The diagnosis of sarcomatoid carcinoma of the lung is made by lung biopsy. | |||
*Biopsy findings associated with sarcomatoid carcinoma of the lung will depend on the subtype of tumor histology, common findings include: | |||
:* | |||
:* | |||
:* | |||
== | === Symptoms === | ||
*Common symptoms of sarcomatoid carcinoma of the lung may include the following: | |||
:*Shortness of breath | |||
:*Fatigue | |||
:*Chest pain | |||
==[[ | === Physical Examination === | ||
*Patients with sarcomatoid carcinoma of the lung usually appear older in age in relation to their chronological age. | |||
*Physical examination may be remarkable for: | |||
'''Inspection''' | |||
*Performed in the anterior chest/posterior chest | |||
*Hoarseness | |||
*Rapid rate of breathing | |||
'''Auscultation''' | |||
*Present [[pleural friction rub]] | |||
*Present [[egophony]] | |||
*Crackling or bubbling noises | |||
*Present whispered pectoriloquy | |||
*Decreased/absent [[breath sounds]] | |||
'''Percussion''' | |||
*Hyporesonance | |||
*Dull percussion | |||
*[[Tactile fremitus]] | |||
*Reduced chest expansion | |||
=== Laboratory Findings === | |||
*There are no specific laboratory findings associated with sarcomatoid carcinoma of the lung. | |||
===Imaging Findings=== | |||
*CT scan is the imaging modality of choice for sarcomatoid carcinoma of the lung. | |||
*On CT, sarcomatoid carcinoma of the lung is characterized by the following findings: | |||
== | |||
=== Other Diagnostic Studies === | |||
*Sarcomatoid carcinoma of the lung may also be diagnosed using [diagnostic study name]. | |||
*Findings on may include: | |||
:* | |||
:* | |||
:* | |||
== Treatment == | |||
=== Medical Therapy === | |||
*There is no treatment for sarcomatoid carcinoma of the lung; the mainstay of therapy is supportive care. | |||
*The mainstay of therapy for sarcomatoid carcinoma of the lung is [medical therapy 1] and [medical therapy 2]. | |||
*[Medical therapy 1] acts by [mechanism of action1]. | |||
*Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration]. | |||
=== Surgery === | |||
*Surgery is the mainstay of therapy for sarcomatoid carcinoma of the lung. | |||
*[Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of sarcomatoid carcinoma of the lung. | |||
*[Surgical procedure] can only be performed for patients with [disease stage] sarcomatoid carcinoma of the lung. | |||
=== Prevention === | |||
*There are no primary preventive measures available for sarcomatoid carcinoma of the lung. | |||
*Effective measures for the primary prevention of sarcomatoid carcinoma of the lung include [measure1], [measure2], and [measure3]. | |||
*Once diagnosed and successfully treated, patients with sarcomatoid carcinoma of the lung are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3]. | |||
==References== | |||
{{Reflist|2}} | |||
== | |||
[[Category:Pick One of 28 Approved]] | |||
{{ | |||
[[Category: | |||
Revision as of 20:05, 31 March 2016
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3
Overview
Sarcomatoid carcinoma of the lung is a rare histologic subtype of non-small cell lung cancer. Sarcomatoid carcinoma of the lung is a "sarcoma-like" carcinoma neoplasm. The overall prevalence of sarcomatoid carcinoma of the lung is 0.1% to 0.4% of all lung malignancies.[1]
Historical Perspective
- In 1988, EGFR gene mutations were first identified in the pathogenesis of sarcomatoid carcinoma of the lung.
Classification
- Sarcomatoid carcinoma of the lung may be classified according to WHO classification into 5 subtypes:
- Pleomorphic carcinoma
- Spindle cell carcinoma
- Giant cell carcinoma
- Carcinosarcoma
- Pulmonary blastoma
- Other variants of sarcomatoid carcinoma of the lung is primary lung sarcoma.
Pathophysiology
- The pathogenesis of sarcomatoid carcinoma of the lung is characterized by a rare epithelial origin, and morphologic features suggestive of a malignant mesenchymal tumour.
- Sarcomatoid carcinoma of the lung arises from epithelial cells but has morphologic features suggestive of a malignant mesenchymal tumour It is a sarcoma-like carcinoma.
- The EGFR gene and K-ras mutations mutation has been associated with the development of sarcomatoid carcinoma of the lung.
- On gross pathology, a large size, mass lesion, upper lobe and peripheral located are characteristic findings of sarcomatoid carcinoma of the lung.
- On microscopic histopathological analysis, sarcomatous components are characteristic findings of sarcomatoid carcinoma of the lung.
Causes
- Sarcomatoid carcinoma of the lung may be caused by a mutation in the EGFR and K-ras genes.
Differentiating sarcomatoid carcinoma of the lung from other Diseases
- Sarcomatoid carcinoma of the lung must be differentiated from other diseases that cause cough, weight loss, hemoptysis, and dyspnea among adults, such as:
- Tuberculosis
- Adenocarcinoma of the lung
- Pulmonary fungal disease
- Lung abscess
Epidemiology and Demographics
- The prevalence of sarcomatoid carcinoma of the lung is approximately 0.4 cases per 100,000 individuals worldwide.
- The overall prevalence of sarcomatoid carcinoma of the lung is 0.1% to 0.4% of all lung malignancies.[1]
Age
- Sarcomatoid carcinoma of the lung is more commonly observed among patients aged 50 to 75 years old.
- Sarcomatoid carcinoma of the lung is more commonly observed among elderly patients and adults
Gender
- Males are more commonly affected with sarcomatoid carcinoma of the lung than [gender 2].
Race
- There is no racial predilection for sarcomatoid carcinoma of the lung.
- [Disease name] usually affects individuals of the [race 1] race.
- [Race 2] individuals are less likely to develop sarcomatoid carcinoma of the lung.
Risk Factors
- Common risk factors in the development of sarcomatoid carcinoma of the lung are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
Natural History, Complications and Prognosis
- The majority of patients with sarcomatoid carcinoma of the lung remain asymptomatic for [duration/years].
- Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
- If left untreated, [#%] of patients with sarcomatoid carcinoma of the lung may progress to develop lymphatic invasion, distant metastasis, and
- Common complications of sarcomatoid carcinoma of the lung include respiratory failure, pneumonia, and distant metastasis.
- Prognosis is generally poor, and the average 5- survival rate of patients with sarcomatoid carcinoma of the lung is approximately [#%].
Diagnosis
Diagnostic Criteria
- The diagnosis of sarcomatoid carcinoma of the lung is made by lung biopsy.
- Biopsy findings associated with sarcomatoid carcinoma of the lung will depend on the subtype of tumor histology, common findings include:
Symptoms
- Common symptoms of sarcomatoid carcinoma of the lung may include the following:
- Shortness of breath
- Fatigue
- Chest pain
Physical Examination
- Patients with sarcomatoid carcinoma of the lung usually appear older in age in relation to their chronological age.
- Physical examination may be remarkable for:
Inspection
- Performed in the anterior chest/posterior chest
- Hoarseness
- Rapid rate of breathing
Auscultation
- Present pleural friction rub
- Present egophony
- Crackling or bubbling noises
- Present whispered pectoriloquy
- Decreased/absent breath sounds
Percussion
- Hyporesonance
- Dull percussion
- Tactile fremitus
- Reduced chest expansion
Laboratory Findings
- There are no specific laboratory findings associated with sarcomatoid carcinoma of the lung.
Imaging Findings
- CT scan is the imaging modality of choice for sarcomatoid carcinoma of the lung.
- On CT, sarcomatoid carcinoma of the lung is characterized by the following findings:
Other Diagnostic Studies
- Sarcomatoid carcinoma of the lung may also be diagnosed using [diagnostic study name].
- Findings on may include:
Treatment
Medical Therapy
- There is no treatment for sarcomatoid carcinoma of the lung; the mainstay of therapy is supportive care.
- The mainstay of therapy for sarcomatoid carcinoma of the lung is [medical therapy 1] and [medical therapy 2].
- [Medical therapy 1] acts by [mechanism of action1].
- Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].
Surgery
- Surgery is the mainstay of therapy for sarcomatoid carcinoma of the lung.
- [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of sarcomatoid carcinoma of the lung.
- [Surgical procedure] can only be performed for patients with [disease stage] sarcomatoid carcinoma of the lung.
Prevention
- There are no primary preventive measures available for sarcomatoid carcinoma of the lung.
- Effective measures for the primary prevention of sarcomatoid carcinoma of the lung include [measure1], [measure2], and [measure3].
- Once diagnosed and successfully treated, patients with sarcomatoid carcinoma of the lung are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3].