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Differentiating Legionnaires' disease from other diseases

The following conditions must be considered in the differential diagnosis of Legionnaires' disease: DDx [1][2][3][4][5][6][7]

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Mahshid Mir, M.D. [2]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3] Mahshid Mir, M.D. [4]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [5] Mahshid Mir, M.D. [6]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [7] Mahshid Mir, M.D. [8]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [9] Mahshid Mir, M.D. [10]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [11] Mahshid Mir, M.D. [12]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [13] Mahshid Mir, M.D. [14]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Distinctive features of Legionnaires' disease

Signs and symptoms

  • High grade fever
  • Dry cough
  • Progressive dyspnea
  • Bronchial breath sounds
  • Adult respiratory distress syndrome

Laboratory abnormalities

  • Legionella urinary antigen positive
  • Alveolar consolidation on chest radiograph
  • Lobar consolidation on chest radiograph

Distinctive features of Acute interstitial pneumonia

Signs and symptoms

  • Dry cough
  • Progressive dyspnea
  • Adult respiratory distress syndrome

Laboratory abnormalities

  • Disseminated consolidation on chest radiograph
  • Interstitial infiltrate on chest radiograph
  • Increased uptake on Gallium scan

Distinctive features of Mycoplasma pneumonia

Signs and symptoms

  • Dry cough
  • Pleuritic chest pain
  • Inflammed, opaque, hypomobile tympanic membrane
  • Bronchial breath sounds

Laboratory abnormalities

  • Lymphocytosis
  • Cold agglutinins positive
  • Alveolar consolidation on chest radiograph
  • Interstitial infiltrate on chest radiograph
  • Lobar consolidation on chest radiograph

Distinctive features of Pneumococcal pneumonia

Signs and symptoms

  • Hemoptysis
  • Fine rales
  • Pleuritic chest pain
  • Increased breath sounds
  • Bronchial breath sounds
  • Chest dull to percussion
  • Purulent sputum
  • Shallow respiration
  • Pectoriloquy
  • Increased tactile fremitus
  • Productive cough
  • Egophony
  • High grade fever

Laboratory abnormalities

  • Pleural effusion (exudative)
  • Respiratory alkalosis
  • Parenchymal hyperlucency on chest radiograph
  • Increased uptake on Gallium scan
  • Unilateral diaphragm elevation on chest radiograph
  • Alveolar consolidation on chest radiograph
  • Lobar consolidation on chest radiograph
  • Gram positive diplococci on sputum Gram stain

Distinctive features of Pneumocystis carinii pneumonia

Signs and symptoms

  • Immunosuppressive state
  • Mediastinal emphysema
  • Subcutaneous emphysema
  • Hacking cough
  • Progressive dyspnea

Laboratory abnormalities

  • Respiratory alkalosis
  • Serum beta-D-glucan elevated
  • Alveolar consolidation on chest radiograph
  • Lobar consolidation on chest radiograph
  • Interstitial infiltrate on chest radiograph

Distinctive features of Pulmonary embolism

Signs and symptoms

  • Calf pain / swelling
  • Decreased pulse pressure
  • Dyspnea with normal chest X-ray
  • Hemoptysis
  • Hyperventilation
  • Immobility
  • Increased pulmonic component of heart sound
  • Pleuritic chest pain
  • Prior DVT
  • Pulmonary hypertension
  • Right ventricular heave
  • Right ventricular hypertrophy
  • Right-to-left shunt
  • Substernal chest pain
  • Tachypnea
  • Thrombophlebitis
  • Unilateral lower extremity edema
  • Venous stasis


Laboratory abnormalities

  • Atrial fibrillation
  • Bone fracture
  • Atelectasis on chest radiograph
  • Lobar consolidation on chest radiograph
  • Prominent pulmonary artery on chest radiograph
  • Hampton's hump on chest radiograph
  • D-dimer elevated
  • Right ventricular enlargement on echocardiography
  • Thrombus on echocardiography
  • Hypocapnia
  • Hypoxia
  • Segmental perfusion defect on lung scan
  • V/Q mismatch on lung scan
  • Pleural effusion (exudative / bloody)
  • RVH on ECG
  • Right axis deviation on ECG

Distinctive features of Streptococcal pneumonia

Signs and symptoms

Laboratory abnormalities

Distinctive features of Viral pneumonia

Signs and symptoms

Laboratory abnormalities

  1. Ferri, Fred (2011). Ferri's differential diagnosis: a practical guide to the differential diagnosis of symptoms, signs, and clinical disorders. Philadelphia, PA: Elsevier/Mosby. ISBN 978-0323076999.
  2. Siegenthaler, Walter (2007). Differential diagnosis in internal medicine: from symptom to diagnosis. Stuttgart New York: Thieme. ISBN 978-1588905512.
  3. Mesko, Dusan (2002). Differential diagnosis by laboratory medicine: a quick reference for physicians. Berlin New York: Springer-Verlag. ISBN 978-3540430575.
  4. Reeder and Felson's gamuts in radiology: comprehensive lists of roentgen differential diagnosis. Place of publication not identified: Springer. 2014. ISBN 978-1475781229.
  5. Burgener, Francis (2008). Differential diagnosis in conventional radiology. Stuttgart New York: Thieme. ISBN 978-1588902757.
  6. Gattuso, Paolo (2015). Differential diagnosis in surgical pathology. Philadelphia, PA: Saunders/Elsevier. ISBN 978-1455770137.
  7. "DXplain".