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<h5>Meningitis, tuberculous {{ID-returntotop-organ}}</h5> | <h5>Meningitis, tuberculous {{ID-returntotop-organ}}</h5> | ||
* Tuberculous meningitis<ref>{{Cite journal| doi = 10.1164/rccm.167.4.603| issn = 1073-449X| volume = 167| issue = 4| pages = 603–662| last1 = Blumberg| first1 = Henry M.| last2 = Burman| first2 = William J.| last3 = Chaisson| first3 = Richard E.| last4 = Daley| first4 = Charles L.| last5 = Etkind| first5 = Sue C.| last6 = Friedman| first6 = Lloyd N.| last7 = Fujiwara| first7 = Paula| last8 = Grzemska| first8 = Malgosia| last9 = Hopewell| first9 = Philip C.| last10 = Iseman| first10 = Michael D.| last11 = Jasmer| first11 = Robert M.| last12 = Koppaka| first12 = Venkatarama| last13 = Menzies| first13 = Richard I.| last14 = O'Brien| first14 = Richard J.| last15 = Reves| first15 = Randall R.| last16 = Reichman| first16 = Lee B.| last17 = Simone| first17 = Patricia M.| last18 = Starke| first18 = Jeffrey R.| last19 = Vernon| first19 = Andrew A.| last20 = American Thoracic Society, Centers for Disease Control and Prevention and the Infectious Diseases Society| title = American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis| journal = American Journal of Respiratory and Critical Care Medicine| date = 2003-02-15| pmid = 12588714 | * Tuberculous meningitis<ref>{{Cite journal| doi = 10.1164/rccm.167.4.603| issn = 1073-449X| volume = 167| issue = 4| pages = 603–662| last1 = Blumberg| first1 = Henry M.| last2 = Burman| first2 = William J.| last3 = Chaisson| first3 = Richard E.| last4 = Daley| first4 = Charles L.| last5 = Etkind| first5 = Sue C.| last6 = Friedman| first6 = Lloyd N.| last7 = Fujiwara| first7 = Paula| last8 = Grzemska| first8 = Malgosia| last9 = Hopewell| first9 = Philip C.| last10 = Iseman| first10 = Michael D.| last11 = Jasmer| first11 = Robert M.| last12 = Koppaka| first12 = Venkatarama| last13 = Menzies| first13 = Richard I.| last14 = O'Brien| first14 = Richard J.| last15 = Reves| first15 = Randall R.| last16 = Reichman| first16 = Lee B.| last17 = Simone| first17 = Patricia M.| last18 = Starke| first18 = Jeffrey R.| last19 = Vernon| first19 = Andrew A.| last20 = American Thoracic Society, Centers for Disease Control and Prevention and the Infectious Diseases Society| title = American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis| journal = American Journal of Respiratory and Critical Care Medicine| date = 2003-02-15| pmid = 12588714}}</ref> | ||
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:* Alternative regimen (2): 2 months of [[Isoniazid]] 10 (8–12)mg/kg 3 times per week {{and}} [[Rifampicin]] 10 (8–12)mg/kg 3 times per week {{and}} [[Pyrazinamide]] 35 (30–40)mg/kg 3 times per week {{and}} [[Streptomycina]] 15 (12–18)mg/kg 3 times per week followed by 7-10 months of [[Isoniazid]] 10 (8–12)mg/kg 3 times per week {{and}} [[Rifampicin]] 10 (8–12)mg/kg 3 times per week | :* Alternative regimen (2): 2 months of [[Isoniazid]] 10 (8–12)mg/kg 3 times per week {{and}} [[Rifampicin]] 10 (8–12)mg/kg 3 times per week {{and}} [[Pyrazinamide]] 35 (30–40)mg/kg 3 times per week {{and}} [[Streptomycina]] 15 (12–18)mg/kg 3 times per week followed by 7-10 months of [[Isoniazid]] 10 (8–12)mg/kg 3 times per week {{and}} [[Rifampicin]] 10 (8–12)mg/kg 3 times per week | ||
:* '''Intensive phase treatment''' | |||
::* Preferred regimen: HRZS | |||
:* '''Continuation phase''' | |||
::* Preferred regimen: HR | |||
Note (3): Adjuvant corticosteroid treatment is recommended unless drug resistance is suspected. | |||
Note (1): World Health Organization guidelines recommend that ethambutol should be replaced by streptomycin in tuberculous meningitis.<ref>{{Cite book| edition = 4th| publisher = World Health Organization| isbn = 9789241547833| title = Treatment of Tuberculosis: Guidelines| location = Geneva| series = WHO Guidelines Approved by the Guidelines Review Committee| accessdate = 2015-06-08| date = 2010| url = http://www.ncbi.nlm.nih.gov/books/NBK138748/| pmid = 23741786}}</ref> | |||
Note (2): A 9– to 12–month course of treatment is recommended for tuberculous meningitis.<ref>{{Cite book| edition = 4th| publisher = World Health Organization| isbn = 9789241547833| title = Treatment of Tuberculosis: Guidelines| location = Geneva| series = WHO Guidelines Approved by the Guidelines Review Committee| accessdate = 2015-06-08| date = 2010| url = http://www.ncbi.nlm.nih.gov/books/NBK138748/| pmid = 23741786}}</ref> | |||
Note (3): Adjuvant corticosteroid treatment is recommended unless drug resistance is suspected.<ref>{{Cite journal| doi = 10.1056/NEJMoa040573| issn = 1533-4406| volume = 351| issue = 17| pages = 1741–1751| last1 = Thwaites| first1 = Guy E.| last2 = Nguyen| first2 = Duc Bang| last3 = Nguyen| first3 = Huy Dung| last4 = Hoang| first4 = Thi Quy| last5 = Do| first5 = Thi Tuong Oanh| last6 = Nguyen| first6 = Thi Cam Thoa| last7 = Nguyen| first7 = Quang Hien| last8 = Nguyen| first8 = Tri Thuc| last9 = Nguyen| first9 = Ngoc Hai| last10 = Nguyen| first10 = Thi Ngoc Lan| last11 = Nguyen| first11 = Ngoc Lan| last12 = Nguyen| first12 = Hong Duc| last13 = Vu| first13 = Ngoc Tuan| last14 = Cao| first14 = Huu Hiep| last15 = Tran| first15 = Thi Hong Chau| last16 = Pham| first16 = Phuong Mai| last17 = Nguyen| first17 = Thi Dung| last18 = Stepniewska| first18 = Kasia| last19 = White| first19 = Nicholas J.| last20 = Tran| first20 = Tinh Hien| last21 = Farrar| first21 = Jeremy J.| title = Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults| journal = The New England Journal of Medicine| date = 2004-10-21| pmid = 15496623}}</ref> | |||
Revision as of 06:59, 8 June 2015
Meningitis, tuberculous ⇧ Return to Top ⇧
- Tuberculous meningitis[1]
- Preferred regimen: 2 months of Isoniazid 5 (4–6)mg/kg OD AND Rifampicin 10 (8–12)mg/kg OD AND Pyrazinamide 25 (20–30)mg/kg OD AND Streptomycin 15 (12–18)mg/kg OD followed by 7-10 months of Isoniazid 5 (4–6)mg/kg OD AND Rifampicin 10 (8–12)mg/kg OD
- Alternative regimen (1): 2 months of Isoniazid 5 (4–6)mg/kg OD AND Rifampicin 10 (8–12)mg/kg OD AND Pyrazinamide 25 (20–30)mg/kg OD AND Streptomycin 15 (12–18)mg/kg OD followed by 7-10 months of Isoniazid 10 (8–12)mg/kg 3 times per week AND Rifampicin 10 (8–12)mg/kg 3 times per week
- Alternative regimen (2): 2 months of Isoniazid 10 (8–12)mg/kg 3 times per week AND Rifampicin 10 (8–12)mg/kg 3 times per week AND Pyrazinamide 35 (30–40)mg/kg 3 times per week AND Streptomycina 15 (12–18)mg/kg 3 times per week followed by 7-10 months of Isoniazid 10 (8–12)mg/kg 3 times per week AND Rifampicin 10 (8–12)mg/kg 3 times per week
- Intensive phase treatment
- Preferred regimen: HRZS
- Continuation phase
- Preferred regimen: HR
Note (1): World Health Organization guidelines recommend that ethambutol should be replaced by streptomycin in tuberculous meningitis.[2] Note (2): A 9– to 12–month course of treatment is recommended for tuberculous meningitis.[3] Note (3): Adjuvant corticosteroid treatment is recommended unless drug resistance is suspected.[4]
- ↑ Blumberg, Henry M.; Burman, William J.; Chaisson, Richard E.; Daley, Charles L.; Etkind, Sue C.; Friedman, Lloyd N.; Fujiwara, Paula; Grzemska, Malgosia; Hopewell, Philip C.; Iseman, Michael D.; Jasmer, Robert M.; Koppaka, Venkatarama; Menzies, Richard I.; O'Brien, Richard J.; Reves, Randall R.; Reichman, Lee B.; Simone, Patricia M.; Starke, Jeffrey R.; Vernon, Andrew A.; American Thoracic Society, Centers for Disease Control and Prevention and the Infectious Diseases Society (2003-02-15). "American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis". American Journal of Respiratory and Critical Care Medicine. 167 (4): 603–662. doi:10.1164/rccm.167.4.603. ISSN 1073-449X. PMID 12588714.
- ↑ Treatment of Tuberculosis: Guidelines. WHO Guidelines Approved by the Guidelines Review Committee (4th ed.). Geneva: World Health Organization. 2010. ISBN 9789241547833. PMID 23741786. Retrieved 2015-06-08.
- ↑ Treatment of Tuberculosis: Guidelines. WHO Guidelines Approved by the Guidelines Review Committee (4th ed.). Geneva: World Health Organization. 2010. ISBN 9789241547833. PMID 23741786. Retrieved 2015-06-08.
- ↑ Thwaites, Guy E.; Nguyen, Duc Bang; Nguyen, Huy Dung; Hoang, Thi Quy; Do, Thi Tuong Oanh; Nguyen, Thi Cam Thoa; Nguyen, Quang Hien; Nguyen, Tri Thuc; Nguyen, Ngoc Hai; Nguyen, Thi Ngoc Lan; Nguyen, Ngoc Lan; Nguyen, Hong Duc; Vu, Ngoc Tuan; Cao, Huu Hiep; Tran, Thi Hong Chau; Pham, Phuong Mai; Nguyen, Thi Dung; Stepniewska, Kasia; White, Nicholas J.; Tran, Tinh Hien; Farrar, Jeremy J. (2004-10-21). "Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults". The New England Journal of Medicine. 351 (17): 1741–1751. doi:10.1056/NEJMoa040573. ISSN 1533-4406. PMID 15496623.