Sandbox encephalitis

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Encephalitis

Community-Acquired
  ▸  Herpes simplex virus
  ▸  Varicella zoster virus
  ▸  Cytomegalovirus
  ▸  Epstein-Barr virus
  ▸  Human herpesvirus 6
  ▸  B Virus
  ▸  Other viruses
  ▸  ADEM
Herpes simplex virus
patients with normal renal function
Acyclovir 10 mg/kg IV q8h(for 14-21 days)
neonates
Acyclovir 20 mg/kg IV q8h(for 21 days)
Varicella zoster virus
Preferred Regimen
acyclovir 10–15 mg/kg IV q8h (for 10–14 days)
PLUS
Cefotaxime 50 mg/kg IV q6—8h
Alternative Regimen
Ganciclovir
Cytomegalovirus
Preferred Regimen
Ganciclovir 5 mg/kg IV q12 h
PLUS
Foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h
Human herpesvirus 6
Immunocompromised Patients
Ganciclovir 5 mg/kg IV q12 h
OR
Foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h
Immunocompetent Patients
No good data on effectiveness yet
B virus
Preferred Regimen
Valacyclovir 5 mg/kg IV q12 h
Alternative Regimen
Ganciclovir
AND
Acyclovir