Sandbox MWH: Difference between revisions

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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Subtypes
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Year
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Explanation
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Discovery
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! style="background: #DCDCDC; text-align: center;" |'''Relapsing remitting'''
! style="background: #DCDCDC; text-align: center;" |'''1877'''
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* Relapsing-remitting multiple sclerosis (RRMS) is defined by acute attacks of [[neurological]] [[dysfunction]] followed by full or partial [[recovery]]. Patient [[History and Physical examination|clinical symptoms]] are stable between the attacks
* First-ever description of narcolepsy in the medical literature
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! style="background: #DCDCDC; text-align: center;" |'''Secondary progressive'''
! style="background: #DCDCDC; text-align: center;" |'''1880'''
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* Patient with long term RRMS can switch to secondary relapsing multiple sclerosis (SPMS) when the [[neurological]] [[symptoms]] progressively worsen between the attacks
* Gelineau named the disorder “narcolepsy”
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! style="background: #DCDCDC; text-align: center;" |'''Primary progressive'''
! style="background: #DCDCDC; text-align: center;" |'''1902'''
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* Primary progressive multiple sclerosis (PPMS) is defined by continuously worsening of [[neurological]] [[dysfunction]] with no distinct attacks and [[remission]]<nowiki/>s
*Loewenfeld first coined the term “cataplexy” 
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! style="background: #DCDCDC; text-align: center;" |'''Progressive relapsing'''
! style="background: #DCDCDC; text-align: center;" |'''1935'''
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* First-ever use of amphetamines in the treatment of narcolepsy
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Revision as of 16:03, 14 August 2020


Year Discovery
1877
  • First-ever description of narcolepsy in the medical literature
1880
  • Gelineau named the disorder “narcolepsy”
1902
  • Loewenfeld first coined the term “cataplexy”
1935
  • First-ever use of amphetamines in the treatment of narcolepsy


Table 1: A few milestones in narcolepsy research and therapy 1877 First description in the medical literature (100) 1880 Gelineau called the disorder “narcolepsy” (28) 1902 Loewenfeld coined the term “cataplexy” (53) 1935 First use of amphetamines in the treatment of narcolepsy (87) 1960 Description of Sleep Onset REM periods in a narcoleptic subject (99) 1970 Description of the Multiple Latency Test (15, 90) 1973 First report of a narcoleptic dog (47, 72) 1983 Association of narcolepsy with HLA-DR2 (37) 1985 Monoaminergic and cholinergic imbalance in narcolepsy (7, 80) 1992 Association of narcolepsy with HLA-DQB1*0602 (56, 63) 1998 Identification of hypocretins/orexins and their receptors (18, 93) 1999 Hypocretin mutations cause narcolepsy in mice and dogs (16, 51) 2000 Human narcolepsy is also associated with an hypocretin deficiency (81)

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