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ImageName.jpg | Description <br> [http://phil.cdc.gov/Phil/ <font size="-2">''Adapted from CDC''</font>]
ImageName.jpg | Description <br> [http://www.cdc.gov/dpdx/ <font size="-2">''Adapted from CDC''</font>]
ImageName.jpg | Description <br> [http://www.cdc.gov/ticks/geographic_distribution.html <font size="-2">''Adapted from CDC''</font>]

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Sexually Transmitted Disease Gallery

Bacterial vaginosis

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  This photomicrograph of a vaginal smear specimen depicts two epithelial cells, a normal cell, and an epithelial cell with its exterior covered by bacteria giving the cell a roughened, stippled appearance known as a “clue cell”. Clue cells are epithelial cells that have had bacteria adhere to their surface, obscuring their borders, and imparting a stippled appearance. The presence of such clue cells is a sign that the patient has bacterial vaginosis. Adapted from CDC

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  This photograph depicted a single Gardnerella vaginalis, formerly Haemophilus vaginalis, or Corynebacterium vaginalis, bacterial colony.The vagina is normally colonized by Lactobacillus spp., which help to regulate the region’s pH, maintaining it in the low range, thereby, inhibiting the growth of potentially-pathogenic organisms. The Gram-positive Gardnerella vaginalis bacterium is one such organism, and is a common cause for bacterial vaginosis (BV). Adapted from CDC

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  This photograph depicted a single Gardnerella vaginalis, formerly Haemophilus vaginalis, or Corynebacterium vaginalis, bacterial colony. The vagina is normally colonized by Lactobacillus spp., which help to regulate the region’s pH, maintaining it in the low range, thereby, inhibiting the growth of potentially-pathogenic organisms. The Gram-positive Gardnerella vaginalis bacterium is one such organism, and is a common cause for bacterial vaginosis (BV). Adapted from CDC

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  This photomicrograph reveals bacteria adhering to vaginal epithelial cells known as “clue cells”. “Clue cells” are epithelial cells that have had bacteria adhere to their surface, obscuring their borders, and imparting a stippled appearance. The presence of such clue cells is a sign that the patient has bacterial vaginosis. Adapted from CDC

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  This photomicrograph reveals bacteria adhering to vaginal epithelial cells known as “clue cells”. “Clue cells” are epithelial cells that have had bacteria adhere to their surface, obscuring their borders, and imparting a stippled appearance. The presence of such clue cells is a sign that the patient has bacterial vaginosis. Adapted from CDC

Chlamydia

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  Under a relatively-low magnification of 63X, this Gram-stained photomicrograph of a vaginal specimen revealed the presence of squamous epithelial cells, polymorphonuclear leukocytes (PMNs), or white blood cells (WBCs), and numerous Gram-positive bacilli, or rods. Vaginal specimens are reviewed for many reasons including the Pap test, tests for STDs such as human papilloma virus (HPV) andChlamydia trachomatis , as well as others. The vagina is normally home to a number of bacterial organisms, referred to as vaginal microbiota, or vaginal microflora, composed primarily of rod-shaped Lactobacillus spp., as well as others. Adapted from CDC

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  Photomicrograph of Chlamydia trachomatis taken from a urethral scrape. Untreated, chlamydia can cause severe, costly reproductive and other health problems including both short- and long-term consequences, i.e. pelvic inflammatory disease (PID), infertility, and potentially fatal tubal pregnancy. Adapted from CDC

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  This McCoy cell monolayer micrograph reveals a number of intracellular C. trachomatis inclusion bodies; Magnified 50X. The intracellular inclusion body represents the replication phase of the Chlamydia spp. organisms, whereupon, the reorganized reticulate body (RB) multiplies through binary fission into 100-500 new RBs, which mature into elementary bodies (EB). Adapted from CDC

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  This image reveals a close view of a patient’s left eye with the upper lid retracted in order to reveal the inflamed conjunctival membrane lining the inside of both the upper and lower lids, due to what was determined to be a case of inclusion conjunctivitis, a type of conjunctival inflammation caused by the bacterium, Chlamydia trachomatis. Inclusion conjunctivitis, also known as chlamydial conjunctivitis, is more common in newborns. Symptoms include redness of the eye(s), swelling of the eyelids, and discharge of pus, usually 5 to 12 days after birth. Adapted from CDC

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  This photomicrograph depicts HeLa cells infected with Type-A Chlamydia trachomatis, Magnified 400X. The cell line of choice is McCoy, however a particular strain of HeLa cells, i.e. HeLa 299-24, can be used to culture C. trachomatis. For identification, either iodine or fluorescent antibody (FA) stains are usually used. Adapted from CDC

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  Under a low magnification of 12.5X, this photomicrograph reveals McCoy cell monolayers with Chlamydia trachomatis inclusion bodies. Chlamydia, caused by Chlamydia trachomatis, is the most common bacterial sexually transmitted infection. Using cell cultures from the McCoy cell line is one methods implemented in diagnosing Chlamydial infections. Adapted from CDC

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  This photomicrograph reveals McCoy cell monolayers with Chlamydia trachomatis inclusion bodies; Magnified 50X. Chlamydia, caused by Chlamydia trachomatis, is the most common bacterial sexually transmitted infection. Using cell cultures from the McCoy cell line is one methods implemented in diagnosing Chlamydial infections.Adapted from CDC

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  This photomicrograph reveals McCoy cell monolayers with Chlamydia trachomatis inclusion bodies; Magnified 200X. Chlamydia, caused by Chlamydia trachomatis, is the most common bacterial sexually transmitted infection. Using cell cultures from the McCoy cell line is one methods implemented in diagnosing Chlamydial infections. Adapted from CDC

Gonorrhea

• Description Adapted from CDC

  Description Adapted from CDC

Genital Herpes

• Description Adapted from CDC

  Description Adapted from CDC

HIV/AIDS

• Description Adapted from CDC

  Description Adapted from CDC

Human papillomavirus

• Description Adapted from CDC

  Description Adapted from CDC

Lymphogranuloma venereum

• Description Adapted from CDC

  Description Adapted from CDC

Pubic lice infestation

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  This 2006 image depicted five body lice, Pediculus humanus var. corporis, which from left to right included three nymphal-staged lice, beginning with a stage N1, then N2, and thirdly a N3-staged nymph, followed by an adult male louse, and finally an adult female louse. Lice are parasitic insects that can be found on people's heads, and bodies, including the pubic area. Human lice survive by feeding on human blood. Lice found on each area of the body are different from each other. The three types of lice that live on humans are: Pediculus humanus capitis (head louse), Pediculus humanus corporis (body louse, clothes louse) and Phthirus pubis ("crab" louse, pubic louse). Only the body louse is known to spread disease. Lice infestations are spread most commonly by close person-to-person contact. Dogs, cats, and other pets do not play a role in the transmission of human lice. Lice move by crawling; they cannot hop or fly. Both over-the-counter and prescription medications are available for treatment of lice infestations. Adapted from CDC

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  This photomicrograph depicts a dorsal view of an adult female human head louse, Pediculus humanus var. capitis. Lice are parasitic insects that can be found on people's heads, and bodies, including the pubic area. Human lice survive by feeding on human blood. Lice found on each area of the body are different from each other. The three types of lice that live on humans are: Pediculus humanus var. capitis (head louse), Pediculus humanus var. corporis (body louse, clothes louse) and Pthirus pubis ("crab" louse, pubic louse). Only the body louse is known to spread disease. Lice infestations (pediculosis and pthiriasis) are spread most commonly by close person-to-person contact. Dogs, cats, and other pets do not play a role in the transmission of human lice. Lice move by crawling; they cannot hop or fly. Both over-the-counter and prescription medications are available for treatment of lice infestations. Adapted from CDC

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  This illustration depicts a dorsal view of a “crab louse”, Phthirus pubis, a member of the suborder Anoplura, or “sucking lice”. The crab louse Phthirus pubis, is not known to carry disease producing organisms. Infestations usually occur in the pubic region of humans, and may occasionally be found on other coarse body hair, such as hair on the legs, armpits, mustache, beard, eyebrows, or eyelashes. Infestations of young children are usually on the eyebrows or eyelashes. Lice found on the head are not pubic lice; they are head lice. Adapted from CDC

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  This illustration depicts some of the morphologic differences seen in two “sucking lice” of the Order Annoplura. The louse on the left is a “body louse”, Pediculus humanus var. corporis, and the louse on the right is a “crab” or “pubic louse”, Phthirus pubis. Note that both of these lice are wingless, and possess three pairs of claw-tipped legs, which allows them to firmly grasp the hair shafts to which they remain attached as human ectoparasitic pests. Adapted from CDC

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  This photograph reveals the presence of crab lice, Phthirus pubis with reddish-brown crab feces. Pubic lice are generally found in the genital area on pubic hair; but may occasionally be found on other coarse body hair, such as hair on the legs, armpit, mustache, beard, eyebrows, and eyelashes. Adapted from CDC

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  This is an illustration comparing the Head Louse, Pediculus humanus, with the Pubic Louse, Phthirus pubis. These insects use their hook-like appendages to grasp unto the hair shafts of their hosts in body regions unique to its species, i.e. the head louse infests the head region of its host, while the pubic louse infests its host’s pubic region. Adapted from CDC

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  This patient presented with an infestation of Phthirus pubis, or crab lice. A Phthirus pubis infestation has caused the erythematous lesions seen in the pubic region of this patient in response to the bites of the crab lice arthropods. Adapted from CDC

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  his image depicts a dorsal view of a female head louse, Pediculus humanus var. capitis. Lice are parasitic insects that can be found on people's heads, and bodies, including the pubic area. Human lice survive by feeding on human blood. Lice found on each area of the body are different from each other. The three types of lice that live on humans are: Pediculus humanus var. capitis (head louse), Pediculus humanus var. corporis (body louse, clothes louse) and Pthirus pubis ("crab" louse, pubic louse). Only the body louse is known to spread disease. Lice infestations (pediculosis and pthiriasis) are spread most commonly by close person-to-person contact. Dogs, cats, and other pets do not play a role in the transmission of human lice. Lice move by crawling; they cannot hop or fly. Both over-the-counter and prescription medications are available for treatment of lice infestations. Adapted from CDC

Scabies

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  Under a moderate modification, this photomicrograph revealed the histopathologic changes in a human skin sample from the site of a number of scabies burrows, due to an infestation of Sarcoptes scabiei var. hominis. Note that the scabies had burrowed into the upper layers of this patient’s skin, into the epidermis, superficial to the stratum basale, also known as the stratum germinativum. The most common signs and symptoms of scabies are intense itching (pruritus), especially at night, and a pimple-like (papular) itchy rash. The itching and rash each may affect much of the body or be limited to common sites such as the wrist, elbow, armpit, webbing between the fingers, nipple, penis, waist, belt-line, and buttocks. The rash also can include tiny blisters (vesicles) and scales. Scratching the rash can cause skin sores; sometimes these sores become infected by bacteria. Adapted from CDC

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  This image depicts the anterior aspect of a patient’s lower legs, either of which displaying the pathologic consequences of an infestation of Sarcoptes scabiei var. hominis, otherwise known as scabies. Of note, were the secondary severe excoriations, resulting from the patient having scratched at the primary maculopapular rash caused by the scabies bites. The most common signs and symptoms of scabies are intense itching (pruritus), especially at night, and a pimple-like (papular) itchy rash. The itching and rash each may affect much of the body or be limited to common sites such as the wrist, elbow, armpit, webbing between the fingers, nipple, penis, waist, belt-line, and buttocks. The rash also can include tiny blisters (vesicles) and scales. Scratching the rash can cause skin sores; sometimes these sores become infected by bacteria. Adapted from CDC

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  This close view of the genitalia of a male patient reveals the presence of erosive, inflamed lesions, which had been caused by an infestation of scabies, Sarcoptes scabiei var. hominis. The lesions are on the penile glans, and the preputial skin. The most common signs and symptoms of scabies are intense itching (pruritus), especially at night, and a pimple-like (papular) itchy rash. The itching and rash each may affect much of the body or be limited to common sites such as the wrist, elbow, armpit, webbing between the fingers, nipple, penis, waist, belt-line, and buttocks. The rash also can include tiny blisters (vesicles) and scales. Scratching the rash can cause skin sores; sometimes these sores become infected by bacteria. Adapted from CDC

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  This photograph depicting the dorsal surface of a human hand focused on the interdigital web space between the index and middle fingers, and revealed the presence of papules due to an infestation of the human itch mite, Sarcoptes scabiei var. hominis, otherwise commonly known as scabies. The most common signs and symptoms of scabies are intense itching (pruritus), especially at night, and a pimple-like (papular) itchy rash. The itching and rash each may affect much of the body or be limited to common sites such as the wrist, elbow, armpit, webbing between the fingers, nipple, penis, waist, belt-line, and buttocks. The rash also can include tiny blisters (vesicles) and scales. Scratching the rash can cause skin sores; sometimes these sores become infected by bacteria. Adapted from CDC

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  The right axillary region of this male patient exhibited a papular rash, which had been caused by an infestation of the human itch mite,Sarcoptes scabiei var. hominis, otherwise commonly known as scabies. The most common signs and symptoms of scabies are intense itching (pruritus), especially at night, and a pimple-like (papular) itchy rash. The itching and rash each may affect much of the body or be limited to common sites such as the wrist, elbow, armpit, webbing between the fingers, nipple, penis, waist, belt-line, and buttocks. The rash also can include tiny blisters (vesicles) and scales. Scratching the rash can cause skin sores; sometimes these sores become infected by bacteria. Adapted from CDC

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  This photomicrograph reveals a single human itch mite, Sarcoptes scabiei var. hominis, otherwise commonly known as scabies, that had burrowed itself into the epidermal layers of a skin tissue sample extracted from an unknown host. The microscopic scabies mite burrows into the upper layer of the skin where it lives and lays its eggs. The most common symptoms of scabies are intense itching and a pimple-like skin rash. The scabies mite usually is spread by direct, prolonged, skin-to-skin contact with a person who has scabies. Scabies occurs worldwide and affects people of all races and social classes. Scabies can spread rapidly under crowded conditions where close body contact is frequent. Institutions such as nursing homes, extended-care facilities, and prisons are often sites of scabies outbreaks. Adapted from CDC

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  This woman presented with a rash composed of pimple-like irritations on the abdomen and thorax due to canine scabies. If an animal is infested with scabies, or mange, and comes in close contact with humans, the mites can get under the skin causing itching and irritation. However, this form of scabies is mild, and the mites die in a couple of days without reproducing. Adapted from CDC

Syphilis

• Description Adapted from CDC

  Description Adapted from CDC

Trichomoniasis

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  This photomicrograph of a wet-mounted vaginal discharge specimen, reveals numbers of Trichomonas vaginalis protozoan parasites, leading to a diagnosis of trichomoniasis, or “trich”, which is a very common sexually transmitted disease (STD) that is caused by infection with T. vaginalis. Although symptoms of the disease vary, most women and men who have the parasite cannot tell they are infected. The parasite is passed from an infected person to an uninfected person during sex. In women, the most commonly infected part of the body is the lower genital tract (vulva, vagina, or urethra), and in men, the most commonly infected body part is the inside of the penis (urethra). During sex, the parasite is usually transmitted from a penis to a vagina, or from a vagina to a penis, but it can also be passed from a vagina to another vagina. It is not common for the parasite to infect other body parts, like the hands, mouth, or anus. It is unclear why some people with the infection get symptoms while others do not, but it probably depends on factors like the person’s age and overall health. Infected people without symptoms can still pass the infection on to others. Adapted from CDC

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  This patient presented with a "strawberry cervix” due to a Trichomonas vaginalis infection, or trichomoniasis. The term “strawberry cervix” is used to describe the appearance of the cervix due to the presence of T. vaginalis protozoa. The cervical mucosa reveals punctate hemorrhages along with accompanying vesicles or papules.

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Parasite Gallery

A

Acanthamoeba

Acanthamoeba spp. cysts

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  Cysts of Acanthamoeba spp. in culture.
  Adapted from CDC

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  Cysts of Acanthamoeba spp. in culture.
  Adapted from CDC

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  Cyst of Acanthamoeba sp. from brain tissue, stained with hematoxylin and eosin (H&E).
  Adapted from CDC

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  Cyst of Acanthamoeba sp. from brain tissue, stained with hematoxylin and eosin (H&E).
  Adapted from CDC

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  Cysts of Acanthamoeba sp. (green arrows) in tissue, stained with H&E.
  Adapted from CDC

Acanthamoeba spp. trophozoites

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  Trophozoite of Acanthamoeba sp. from culture. Notice the slender, spine-like acanthapodia.
  Adapted from CDC

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  Trophozoites of Acanthamoeba sp. from culture. Notice the slender, spine-like acanthapodia.
  Adapted from CDC

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  Trophozoite of Acanthamoeba sp. in tissue, stained with hematoxylin and eosin (H&E).
  Adapted from CDC

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  Trophozoites of Acanthamoeba sp. in a corneal scraping, stained with H&E.
  Adapted from CDC

Acanthocephaliasis

• Description Adapted from CDC

  Description
  Adapted from CDC

• Description Adapted from CDC

  Description
  Adapted from CDC

• Description Adapted from CDC

  Description
  Adapted from CDC

B

Balamuthia mandrillaris

Balamuthia mandrillaris cysts

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  Cysts of B. mandrillaris.
  Adapted from CDC

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  Close-up of one of the cysts in Figure 1.
  Adapted from CDC

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  Cyst of B. mandrillaris.
  Adapted from CDC

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  Cyst of B. mandrillaris in brain tissue, stained with hematoxylin and eosin (H&E).
  Adapted from CDC

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  Cyst of B. mandrillaris in brain tissue, stained with hematoxylin and eosin (H&E).
  Adapted from CDC

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  Cyst of B. mandrillaris in brain tissue, stained with H&E. Image courtesy of the University of Kentucky Hospital, Lexington, Kentucky.
  Adapted from CDC

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  Cyst of B. mandrillaris in brain tissue, stained with H&E. Image courtesy of the University of Kentucky Hospital, Lexington, Kentucky.
  Adapted from CDC

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  Cysts of B. mandrillaris in brain tissue, stained with H&E. Image courtesy of Cook Children’s Hospital, Fort Worth, Texas.
  Adapted from CDC

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  Cyst of B. mandrillaris in brain tissue, stained with H&E. Image courtesy of Cook Children’s Hospital, Fort Worth, Texas.
  Adapted from CDC

Balamuthia mandrillaris trophozoites

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  Trophozoite of B. mandrillaris in culture.
  Adapted from CDC

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  Trophozoite of B. mandrillaris in culture.
  Adapted from CDC

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  Trophozoite of B. mandrillaris in culture.
  Adapted from CDC

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  Trophozoite of B. mandrillaris in culture.
  Adapted from CDC

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  Several trophozoites of B. mandrillarisin brain tissue, stained with hematoxylin and eosin (H&E).
  Adapted from CDC

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  A single trophozoite (green arrow) of B. mandrillaris in brain tissue, stained with H&E.
  Adapted from CDC

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  A single trophozoite (black arrow) of B. mandrillaris in brain tissue, stained with H&E.
  Adapted from CDC