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! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Implicated medications}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Implicated medications}}
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Hematologic
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Pulmonary
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hemolytic anemia, thrombocytopenia, granulocytopenia
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Pulmonary fibrosis, hypersensitivity pneumonitis
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Penicillin]], [[quinine]], [[sulfonamides]]
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Nitrofurantoin]], [[bleomycin]], [[methotrexate]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Hepatic
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Hepatic
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hepatitis, cholestatic jaundice
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hepatitis, cholestasis
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Aminosalicylic acid|Para-aminosalicylic acid]], [[sulfonamides]], [[phenothiazines]]
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Aminosalicylic acid|Para-aminosalicylic acid]], [[sulfonamides]], [[phenothiazines]]
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Pulmonary
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Pneumonitis, fibrosis
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Nitrofurantoin]], [[bleomycin]], [[methotrexate]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Renal
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Renal
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Interstitial nephritis, membranous glomerulonephritis  
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Interstitial nephritis, membranous glomerulonephritis  
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Penicillin]], [[sulfonamides]], [[gold]], [[penicillamine]], [[allopurinol]]
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Penicillin]], [[sulfonamides]], [[gold]], [[penicillamine]], [[allopurinol]]
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Hematologic
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hemolytic anemia, thrombocytopenia, granulocytopenia
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Penicillin]], [[quinine]], [[sulfonamides]]
|}
|}


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|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Anaphylaxis
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Anaphylaxis
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Urticaria, angioedema, bronchospasm, gastrointestinal symptoms, hypotension <BR> IgE- and non–IgE-dependent reactions
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Urticaria, angioedema, bronchospasm, gastrointestinal symptoms, hypotension
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Beta-lactam|β-lactam antibiotics]], [[monoclonal antibodies]]
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Beta-lactam|β-lactam antibiotics]], [[monoclonal antibodies]]
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Drug reaction with eosinophilia and systemic symptoms (DRESS)
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Cutaneous eruption, fever, eosinophilia, hepatic dysfunction, lymphadenopathy
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Anticonvulsant]]s, [[sulfonamide]]s, [[minocycline]], [[allopurinol]]
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Serum sickness
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Urticaria, arthralgia, fever
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Heterologous]] [[antibodies]], [[infliximab]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Systemic lupus erythematosus
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Systemic lupus erythematosus
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| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Cutaneous or visceral vasculitis
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Cutaneous or visceral vasculitis
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Hydralazine]], [[penicillamine]], [[propylthiouracil]]
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Hydralazine]], [[penicillamine]], [[propylthiouracil]]
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Serum sickness
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Urticaria, arthralgia, fever
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Heterologous]] [[antibodies]], [[infliximab]]
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Drug reaction with eosinophilia and systemic symptoms (DRESS)
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Cutaneous eruption, fever, eosinophilia, hepatic dysfunction, lymphadenopathy
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Anticonvulsant]]s, [[sulfonamide]]s, [[minocycline]], [[allopurinol]]
|}
|}


Revision as of 19:16, 23 September 2014


Cutaneous reactions Clnical features Implicated medications
Exanthems Delayed-type hypersensitivity
Evolve over days after drug initiation
Diffuse macules and papules 		Aminopenicillins, antibacterial sulfonamides, cephalosporins, allopurinol, anticonvulsants
Urticaria/ angioedema Often IgE mediated
Onset within minutes of drug initiation 		β-lactam antibiotics, ACEIs
Fixed drug eruption Hyperpigmented plaques that recur at same skin or mucosal site NSAIDs, tetracycline, carbamazepine
Pustules Acute generalized eczematous pustulosis (AGEP)
Acneiform 		AGEP: antibiotics, calcium-channel blockers
Acneiform: corticosteroids, sirolimus
Bullous Flaccid blisters
Tense blisters 		Flaccid blisters: captopril, penicillamine
Tense blisters: furosemide, vancomycin
Cutaneous lupus erythematosus Erythematous/scaly plaques in photodistribution Hydrochlorothiazide, calcium-channel blockers, ACEIs
Stevens-Johnson syndrome (SJS) Purpuric macules on face and trunk with <10% epidermal detachment, fever, stomatitis, ocular involvement Antibacterial sulfonamides, oxicam NSAIDs, anticonvulsants, allopurinol
Toxic epidermal necrolysis (TEN) Similar to SJS but >30% epidermal detachment Antibacterial sulfonamides, oxicam NSAIDs, anticonvulsants, allopurinol


Organ-specific reactions Clnical features Implicated medications
Pulmonary Pulmonary fibrosis, hypersensitivity pneumonitis Nitrofurantoin, bleomycin, methotrexate
Hepatic Hepatitis, cholestasis Para-aminosalicylic acid, sulfonamides, phenothiazines
Renal Interstitial nephritis, membranous glomerulonephritis Penicillin, sulfonamides, gold, penicillamine, allopurinol
Hematologic Hemolytic anemia, thrombocytopenia, granulocytopenia Penicillin, quinine, sulfonamides


Multiorgan reactions Clnical features Implicated medications
Anaphylaxis Urticaria, angioedema, bronchospasm, gastrointestinal symptoms, hypotension β-lactam antibiotics, monoclonal antibodies
Systemic lupus erythematosus Arthralgia, myalgias, fever, malaise Hydralazine, procainamide, isoniazid
Vasculitis Cutaneous or visceral vasculitis Hydralazine, penicillamine, propylthiouracil
Serum sickness Urticaria, arthralgia, fever Heterologous antibodies, infliximab
Drug reaction with eosinophilia and systemic symptoms (DRESS) Cutaneous eruption, fever, eosinophilia, hepatic dysfunction, lymphadenopathy Anticonvulsants, sulfonamides, minocycline, allopurinol


[1]

References

  1. ↑ Khan, David A. (2010-02). "Drug allergy". The Journal of Allergy and Clinical Immunology. 125 (2 Suppl 2): –126-137. doi:10.1016/j.jaci.2009.10.028. ISSN 1097-6825. PMID 20176256. Unknown parameter |coauthors= ignored (help); Check date values in: |date= (help)
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