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{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Cutaneous Reactions}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Cutaneous reactions}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Clnical Features}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Clnical features}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Implicated Medications}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Implicated medications}}
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Exanthems
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Exanthems
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Delayed-type hypersensitivity <BR> Evolve over days after drug initiation <BR> Diffuse macules and papules  
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Delayed-type hypersensitivity <BR> Evolve over days after drug initiation <BR> Diffuse macules and papules  
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Aminopenicillins, antibacterial sulfonamides, cephalosporins, allopurinol, antiepileptic agents
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[penicillin|Aminopenicillins]], [[sulfonamides|antibacterial sulfonamides]], [[cephalosporins]], [[allopurinol]], [[anticonvulsants]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Urticaria/ angioedema
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Urticaria/ angioedema
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Often IgE mediated <BR> Onset within minutes of drug initiation
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Often IgE mediated <BR> Onset within minutes of drug initiation
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | β-lactam antibiotics, ACE-Is
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Beta-lactam |β-lactam antibiotics]], [[ACEIs]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Fixed drug eruption
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Fixed drug eruption
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hyperpigmented plaques that recur at same skin or mucosal site
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hyperpigmented plaques that recur at same skin or mucosal site
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | NSAIDs, tetracyline, carbamezapine
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[NSAIDs]], [[tetracycline]], [[carbamazepine]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Pustules
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Pustules
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Acute generalized eczematous pustulosis (AGEP) <BR> Acneiform
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Acute generalized eczematous pustulosis (AGEP) <BR> Acneiform
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | AGEP: antibiotics, calcium-channel blockers <BR> Acneiform: corticosteroids, sirolimus  
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | AGEP: [[antibiotics]], [[calcium-channel blockers]] <BR> Acneiform: [[corticosteroids]], [[sirolimus]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Bullous
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Bullous
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Flaccid blisters <BR> Tense blisters  
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Flaccid blisters <BR> Tense blisters  
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Captopril, penicillamine <BR> Furosemide, vancomycin
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Flaccid blisters: [[captopril]], [[penicillamine]] <BR> Tense blisters: [[furosemide]], [[vancomycin]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Stevens-Johnson Syndrome (SJS)
 
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Purpuric macules on face and trunk with &lt;10% epidermal detachment, fever, stomatitis, ocular involvement,
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Cutaneous lupus erythematosus
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Antibacterial sulfonamides, oxicam NSAIDs, anticonvulsants, allopurinol
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Erythematous/scaly plaques in photodistribution
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Hydrochlorothiazide]], [[calcium-channel blockers]], [[ACEIs]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Toxic Epidermal Necrolysis (TEN)
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Stevens-Johnson syndrome (SJS)
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Similar to SJS but >30% epidermal detachment <BR> Mortality up to 50%
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Purpuric macules on face and trunk with &lt;10% epidermal detachment, fever, stomatitis, ocular involvement
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Same as SJS
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[sulfonamides|Antibacterial sulfonamides]], [[NSAIDs|oxicam NSAIDs]], [[anticonvulsants]], [[allopurinol]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Cutaneous lupus
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Toxic epidermal necrolysis (TEN)
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Erythematous/scaly plaques in photodistribution
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Similar to SJS but >30% epidermal detachment
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hydrochlorothiazide, calcium-channel blockers, ACE-Is
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[sulfonamides|Antibacterial sulfonamides]], [[NSAIDs|oxicam NSAIDs]], [[anticonvulsants]], [[allopurinol]]
|}
|}




{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Extracutaneous Reactions}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Organ-specific reactions}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Clnical Features}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Clnical features}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Implicated Medications}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Implicated medications}}
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Hematologic
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Hematologic
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hemolytic anemia, thrombocytopenia, granulocytopenia
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hemolytic anemia, thrombocytopenia, granulocytopenia
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Penicillin, quinine, sulfonamides
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Penicillin]], [[quinine]], [[sulfonamides]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Hepatic
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Hepatic
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hepatitis, cholestatic jaundice
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hepatitis, cholestatic jaundice
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Para-aminosalacylic acid, sulfonamides, phenothiazines
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Aminosalicylic acid|Para-aminosalicylic acid]], [[sulfonamides]], [[phenothiazines]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Pulmonary
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Pulmonary
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Pneumonitis, fibrosis
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Pneumonitis, fibrosis
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Nitrofurantoin, bleomycin, methotrexate
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Nitrofurantoin]], [[bleomycin]], [[methotrexate]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Renal
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Renal
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Interstitial nephritis, membranous glomerulonephritis  
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Interstitial nephritis, membranous glomerulonephritis  
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Penicillin, sulfonamides, gold, penicillamine, allopurinol
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Penicillin]], [[sulfonamides]], [[gold]], [[penicillamine]], [[allopurinol]]
|}
|}




{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
| style="background: #4479BA; padding: 5px 5px; font-weight: bold;" | {{fontcolor|#FFFFFF|Multiorgan Reactions}}
| style="background: #4479BA; padding: 5px 5px; font-weight: bold;" | {{fontcolor|#FFFFFF|Multiorgan reactions}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Clnical Features}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Clnical features}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Implicated Medications}}
! style="background: #4479BA; padding: 5px 5px;" | {{fontcolor|#FFFFFF|Implicated medications}}
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Anaphylaxis
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Anaphylaxis
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Urticaria, angioedema, bronchospasm, gastrointestinal symptoms, hypotension <BR> IgE- and non–IgE-dependent reactions
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Urticaria, angioedema, bronchospasm, gastrointestinal symptoms, hypotension <BR> IgE- and non–IgE-dependent reactions
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | β-lactam antibiotics, mAbs
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Beta-lactam|β-lactam antibiotics]], [[monoclonal antibodies]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | DRESS
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Drug reaction with eosinophilia and systemic symptoms (DRESS)
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Cutaneous eruption, fever, eosinophilia, hepatic dysfunction, lymphadenopathy
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Cutaneous eruption, fever, eosinophilia, hepatic dysfunction, lymphadenopathy
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Anticonvulsants, sulfonamides, minocycline, allopurinol
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Anticonvulsant]]s, [[sulfonamide]]s, [[minocycline]], [[allopurinol]]
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Serum sickness
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Urticaria, arthralgia, fever
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Heterologous antibodies, [[infliximab]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Serum Sickness
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Systemic lupus erythematosus
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Arthralgias, myalgias, fever, malaise
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Arthralgia, myalgias, fever, malaise
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hydralazine, procainamide, isoniazid
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Hydralazine]], [[procainamide]], [[isoniazid]]
|-
|-
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Vasculitis
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Vasculitis
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Cutaneous or visceral vasculitis
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Cutaneous or visceral vasculitis
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Hydralazine, penicillamine, propylthiouracil
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Hydralazine]], [[penicillamine]], [[propylthiouracil]]
|}
|}


Revision as of 19:05, 23 September 2014


Cutaneous reactions Clnical features Implicated medications
Exanthems Delayed-type hypersensitivity
Evolve over days after drug initiation
Diffuse macules and papules 		Aminopenicillins, antibacterial sulfonamides, cephalosporins, allopurinol, anticonvulsants
Urticaria/ angioedema Often IgE mediated
Onset within minutes of drug initiation 		β-lactam antibiotics, ACEIs
Fixed drug eruption Hyperpigmented plaques that recur at same skin or mucosal site NSAIDs, tetracycline, carbamazepine
Pustules Acute generalized eczematous pustulosis (AGEP)
Acneiform 		AGEP: antibiotics, calcium-channel blockers
Acneiform: corticosteroids, sirolimus
Bullous Flaccid blisters
Tense blisters 		Flaccid blisters: captopril, penicillamine
Tense blisters: furosemide, vancomycin
Cutaneous lupus erythematosus Erythematous/scaly plaques in photodistribution Hydrochlorothiazide, calcium-channel blockers, ACEIs
Stevens-Johnson syndrome (SJS) Purpuric macules on face and trunk with <10% epidermal detachment, fever, stomatitis, ocular involvement Antibacterial sulfonamides, oxicam NSAIDs, anticonvulsants, allopurinol
Toxic epidermal necrolysis (TEN) Similar to SJS but >30% epidermal detachment Antibacterial sulfonamides, oxicam NSAIDs, anticonvulsants, allopurinol


Organ-specific reactions Clnical features Implicated medications
Hematologic Hemolytic anemia, thrombocytopenia, granulocytopenia Penicillin, quinine, sulfonamides
Hepatic Hepatitis, cholestatic jaundice Para-aminosalicylic acid, sulfonamides, phenothiazines
Pulmonary Pneumonitis, fibrosis Nitrofurantoin, bleomycin, methotrexate
Renal Interstitial nephritis, membranous glomerulonephritis Penicillin, sulfonamides, gold, penicillamine, allopurinol


Multiorgan reactions Clnical features Implicated medications
Anaphylaxis Urticaria, angioedema, bronchospasm, gastrointestinal symptoms, hypotension
IgE- and non–IgE-dependent reactions 		β-lactam antibiotics, monoclonal antibodies
Drug reaction with eosinophilia and systemic symptoms (DRESS) Cutaneous eruption, fever, eosinophilia, hepatic dysfunction, lymphadenopathy Anticonvulsants, sulfonamides, minocycline, allopurinol
Serum sickness Urticaria, arthralgia, fever Heterologous antibodies, infliximab
Systemic lupus erythematosus Arthralgia, myalgias, fever, malaise Hydralazine, procainamide, isoniazid
Vasculitis Cutaneous or visceral vasculitis Hydralazine, penicillamine, propylthiouracil


[1]

References

  1. ↑ Khan, David A. (2010-02). "Drug allergy". The Journal of Allergy and Clinical Immunology. 125 (2 Suppl 2): –126-137. doi:10.1016/j.jaci.2009.10.028. ISSN 1097-6825. PMID 20176256. Unknown parameter |coauthors= ignored (help); Check date values in: |date= (help)
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