Sandbox 09232014: Difference between revisions
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| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Pustules | | style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Pustules | ||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | | | style="background: #F5F5F5; padding: 5px 5px;" valign=top | Acute generalized eczematous pustulosis (AGEP) <BR> Acneiform | ||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | | | style="background: #F5F5F5; padding: 5px 5px;" valign=top | AGEP: antibiotics, calcium-channel blockers <BR> Acneiform: corticosteroids, sirolimus | ||
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| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Bullous | | style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Bullous | ||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | | | style="background: #F5F5F5; padding: 5px 5px;" valign=top | Flaccid blisters <BR> Tense blisters | ||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | | | style="background: #F5F5F5; padding: 5px 5px;" valign=top | Captopril, penicillamine <BR> Furosemide, vancomycin | ||
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| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | SJS | | style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Stevens-Johnson Syndrome (SJS) | ||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Fever, erosive stomatitis, ocular involvement, purpuric macules on face and trunk with <10% epidermal detachment | | style="background: #F5F5F5; padding: 5px 5px;" valign=top | Fever, erosive stomatitis, ocular involvement, purpuric macules on face and trunk with <10% epidermal detachment | ||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | Antibacterial sulfonamides, anticonvulsants, oxicam NSAIDs, and allopurinol | | style="background: #F5F5F5; padding: 5px 5px;" valign=top | Antibacterial sulfonamides, anticonvulsants, oxicam NSAIDs, and allopurinol | ||
Revision as of 18:15, 23 September 2014
| Cutaneous Reactions | Clnical Features | Implicated Medications |
|---|---|---|
| Exanthems | Delayed-type hypersensitivity Evolve over days after drug initiation Diffuse macules and papules |
Aminopenicillins, antibacterial sulfonamides, cephalosporins, allopurinol, antiepileptic agents |
| Urticaria/ angioedema | Often IgE mediated Onset within minutes of drug initiation |
β-lactam antibiotics, ACE-Is |
| Fixed drug eruption | Hyperpigmented plaques that recur at same skin or mucosal site | NSAIDs, tetracyline, carbamezapine |
| Pustules | Acute generalized eczematous pustulosis (AGEP) Acneiform |
AGEP: antibiotics, calcium-channel blockers Acneiform: corticosteroids, sirolimus |
| Bullous | Flaccid blisters Tense blisters |
Captopril, penicillamine Furosemide, vancomycin |
| Stevens-Johnson Syndrome (SJS) | Fever, erosive stomatitis, ocular involvement, purpuric macules on face and trunk with <10% epidermal detachment | Antibacterial sulfonamides, anticonvulsants, oxicam NSAIDs, and allopurinol |
| TEN | Similar features as SJS but >30% epidermal detachment Mortality as high as 50% |
Same as SJS |
| Cutaneous lupus | Erythematous/scaly plaques in photodistribution | Hydrochlorothiazide, calcium-channel blockers, ACE-Is |
| Extracutaneous Reactions | Clnical Features | Implicated Medications |
|---|---|---|
| Hematologic | Hemolytic anemia, thrombocytopenia, granulocytopenia | Penicillin, quinine, sulfonamides |
| Hepatic | Hepatitis, cholestatic jaundice | Para-aminosalacylic acid, sulfonamides, phenothiazines |
| Pulmonary | Pneumonitis, fibrosis | Nitrofurantoin, bleomycin, methotrexate |
| Renal | Interstitial nephritis, membranous glomerulonephritis | Penicillin, sulfonamides, gold, penicillamine, allopurinol |
| Multiorgan Reactions | Clnical Features | Implicated Medications |
|---|---|---|
| Anaphylaxis | Urticaria, angioedema, bronchospasm, gastrointestinal symptoms, hypotension IgE- and non–IgE-dependent reactions |
β-lactam antibiotics, mAbs |
| DRESS | Cutaneous eruption, fever, eosinophilia, hepatic dysfunction, lymphadenopathy | Anticonvulsants, sulfonamides, minocycline, allopurinol |
| Serum Sickness | Arthralgias, myalgias, fever, malaise | Hydralazine, procainamide, isoniazid |
| Vasculitis | Cutaneous or visceral vasculitis | Hydralazine, penicillamine, propylthiouracil |