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| <span style="font-size:85%">'''Abbreviations:'''
| | Splenomegaly differential: |
| ABG= [[Arterial blood gas]], ANA= [[Antinuclear antibody]], ANP= [[Atrial natriuretic peptide]], ASO= [[Antistreptolysin O|Antistreptolysin O antibody]], BNP= [[Brain natriuretic peptide]], CBC= [[Complete blood count]], COPD= [[Chronic obstructive pulmonary disease]], CRP= [[C-reactive protein]], CT= [[Computed tomography]], CXR= [[Chest X-ray]], DVT= [[Deep vein thrombosis]], ESR= [[Erythrocyte sedimentation rate]], HRCT= [[High Resolution CT]], IgE= [[Immunoglobulin E]], LDH= [[Lactate dehydrogenase]], PCWP= [[Pulmonary capillary wedge pressure]], PCR= [[Polymerase chain reaction]], PFT= [[Pulmonary function test]].</span>
| |
| | |
| {| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
| |
| ! colspan="3" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
| |
| | colspan="8" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |'''Clinical manifestations'''
| |
| ! colspan="9" rowspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" |Para-clinical findings
| |
| | colspan="1" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
| |
| ! rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
| |
| |-
| |
| | colspan="5" rowspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" |'''Symptoms'''
| |
| ! colspan="3" rowspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" | Physical examination
| |
| |-
| |
| ! colspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Lab Findings
| |
| ! colspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Imaging
| |
| ! rowspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" |Histopathology
| |
| |-
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
| |
| ! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" | Fever
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Weight loss
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Arthralgia
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Claudication
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Bruit
| |
| ! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |HTN
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Focal neurological disorder
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Biomarker
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |CBC
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
| |
| |-
| |
| ! rowspan="9" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Large-Vessel Vasculitis
| |
| ! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Takayasu arteritis]]<ref name="pmid23626437">{{cite journal| author=Vaideeswar P, Deshpande JR| title=Pathology of Takayasu arteritis: A brief review. | journal=Ann Pediatr Cardiol | year= 2013 | volume= 6 | issue= 1 | pages= 52-8 | pmid=23626437 | doi=10.4103/0974-2069.107235 | pmc=3634248 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23626437 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[MMP|MMP-3]] and [[Matrix metalloproteinase|MMP-9]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[CRP]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysm|Aneurysmal dilatation]] of the [[aorta]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Blood vessel]] [[stenosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Circumferential thickening of the [[arterial]] wall (Macaroni sign)
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[PET scan|PET-scan]], [[Cardiac]] [[CT]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Granulomatous]] [[inflammation]] of [[arteries]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Arteriography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Coronary aneurysm]]
| |
| |-
| |
| ! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Giant cell arteritis]]<ref name="pmid13679546">{{cite journal| author=Calvo-Romero JM| title=Giant cell arteritis. | journal=Postgrad Med J | year= 2003 | volume= 79 | issue= 935 | pages= 511-5 | pmid=13679546 | doi= | pmc=1742823 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13679546 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pentraxin|Pentraxin 3 (PTX3)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[CRP]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]], [[Occlusion]], [[Dilatation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysm]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mural [[inflammation]] in [[Magnetic resonance angiography|MRA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Granulomatous]] [[inflammation]] of [[arteries]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Biopsy]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Jaw pain]] and [[Jaw claudication|claudication]]
| |
| |-
| |
| ! rowspan="3" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Neurological disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cerebral aneurysm]]<ref name="pmid20557771">{{cite journal| author=Stafa A, Leonardi M| title=Role of neuroradiology in evaluating cerebral aneurysms. | journal=Interv Neuroradiol | year= 2008 | volume= 14 Suppl 1 | issue= | pages= 23-37 | pmid=20557771 | doi=10.1177/15910199080140S106 | pmc=3328052 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20557771 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Well-defined round, slightly hyperattenuating lesion
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bulging out of the [[Lumen|main lumen]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Heterogeneous]] signal intensity in [[Magnetic resonance angiography|MRA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Layers of [[smooth muscle cells]], Intact [[endothelium]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Digital subtraction angiography|Digital subtraction angiography (DSA)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Nausea]], [[Vomiting]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Neurofibromatosis type 1]]<ref name="pmid28512424">{{cite journal| author=Cassiman C, Casteels I, Stalmans P, Legius E, Jacob J| title=Optical Coherence Tomography Angiography of Retinal Microvascular Changes Overlying Choroidal Nodules in Neurofibromatosis Type 1. | journal=Case Rep Ophthalmol | year= 2017 | volume= 8 | issue= 1 | pages= 214-220 | pmid=28512424 | doi=10.1159/000469702 | pmc=5422752 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28512424 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[NF1|NF1 mutated gene]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Neurofibromin|Neurofibromin gene]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bone disease|Bone abnormalities]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Optical coherence tomography angiography (OCTA)
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Optic nerve gliomas]] in [[MRI]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Elongated spindle-shaped [[cells]] in [[Neurofibroma|neurofibromas]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[National Institutes of Health|NIH]] [[diagnostic criteria]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Café au lait spot|Cafe au Lait spot]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Neurofibromatosis type 2]]<ref name="Evans2000">{{cite journal|last1=Evans|first1=D G. R|title=Neurofibromatosis type 2|journal=Journal of Medical Genetics|volume=37|issue=12|year=2000|pages=897–904|issn=14686244|doi=10.1136/jmg.37.12.897}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[NF2 gene|NF2 mutated gene]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Merlin (protein)|Schwannomin]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Meningioma]], [[Schwannoma]], [[Ependymoma]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fluorescein angiography]] showed [[retinal]] [[hamartoma]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Localized [[schwannomas]] in nerve [[ultrasound]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Schwannoma]] in [[MRI]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Encapsulated biphasic [[nerve sheath]] [[tumor]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[National Institutes of Health|NIH]] [[diagnostic criteria]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hearing loss]], [[Vision loss]]
| |
| |-
| |
| ! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Fibromuscular dysplasia]]<ref name="pmid17555581">{{cite journal| author=Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X| title=Fibromuscular dysplasia. | journal=Orphanet J Rare Dis | year= 2007 | volume= 2 | issue= | pages= 28 | pmid=17555581 | doi=10.1186/1750-1172-2-28 | pmc=1899482 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17555581 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Transforming growth factor β|Transforming growth factor β (TGF-β)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Alternating [[stenosis]] and [[Dilatation|dilatations]] in [[CT angiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]] in the [[renal arteries]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Luminal narrowing alternating with [[dilatation]] (Beads sign)
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal [[concentric]], long-segment [[tubular]] [[stenosis]] or outpouching in [[MRA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Fibrodysplastic changes, [[Collagen]] deposition
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Digital subtraction angiography|Digital subtraction angiography (DSA)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Spontaneous coronary artery dissection|Spontaneous coronary artery dissection (SCAD)]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Ehlers-Danlos syndrome]]<ref name="pmid27824552">{{cite journal| author=Gazit Y, Jacob G, Grahame R| title=Ehlers-Danlos Syndrome-Hypermobility Type: A Much Neglected Multisystemic Disorder. | journal=Rambam Maimonides Med J | year= 2016 | volume= 7 | issue= 4 | pages= | pmid=27824552 | doi=10.5041/RMMJ.10261 | pmc=5101008 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27824552 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[TGF-β]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Cultured skin [[fibroblasts]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Multiple [[vascular]] segments with [[aneurysms]] and [[dissections]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Dissection]] of the [[Circumflex branch of left coronary artery|posterolateral branch of the left circumflex coronary artery (LCx)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Visceral]] [[arteries]] abnormality
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vascular anomaly|Vascular abnormalities]] in [[MRA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Thin and rare [[collagen]] bundles in the [[dermis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bleeding]], [[Easy bruising|Bruisability]], [[Heart murmur]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Polymyalgia rheumatica|Polymyalgia rheumatica (PMR)]]<ref name="pmid18390527">{{cite journal| author=Michet CJ, Matteson EL| title=Polymyalgia rheumatica. | journal=BMJ | year= 2008 | volume= 336 | issue= 7647 | pages= 765-9 | pmid=18390527 | doi=10.1136/bmj.39514.653588.80 | pmc=2287267 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18390527 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fibrinogen|Plasma fibrinogen]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normocytic normochromic anemia|Normocytic, normochromic anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CRP]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Odontoid process|Periodontoid]] localization of [[calcification]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vessel wall]] thickening, Increased mural contrast enhancement
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Subacromial bursitis|Subacromial]] or subdeltoid [[bursitis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |High [[Fluorescein sodium|F-FDG]] accumulation around the [[joints]] in [[Positron emission tomography|FDG PET-CT]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small angular fibers, [[Pyknosis|Pyknotic]] [[nuclear]] clumps, or target-targetoid fibers
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Joint stiffness]], [[Fatigue]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Amyloidosis]]<ref name="pmid23227278">{{cite journal| author=Baker KR, Rice L| title=The amyloidoses: clinical features, diagnosis and treatment. | journal=Methodist Debakey Cardiovasc J | year= 2012 | volume= 8 | issue= 3 | pages= 3-7 | pmid=23227278 | doi= | pmc=3487569 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23227278 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Immunoglobulin light chains|Immunoglobulin light chain]][[Amyloid beta|(Amyloid)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
| |
| ↑ [[ALT]] or [[AST]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Diffusely hypoattenuating and enlarged [[liver]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Amyloid]] deposition in the media and [[adventitia]] of small arteries
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Solid organs increased [[echogenicity]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Tc-DPD for [[cardiac]] '''[[amyloid]]''' deposits
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Extracellular]] deposition of [[Fibrillarin|fibrillar proteins]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Biopsy]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cardiomegaly]], [[Dyspnea]]
| |
| |-
| |
| ! colspan="3" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
| |
| ! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |Fever
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Weight loss
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Arthralgia
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Claudication
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Bruit
| |
| ! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |HTN
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Focal neurological disorder
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Biomarker
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |CBC
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Histopathology
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
| |
| |-
| |
| ! rowspan="18" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Medium-Vessel Vasculitis
| |
| ! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Polyarteritis nodosa]]<ref name="pmid25770638">{{cite journal| author=Howard T, Ahmad K, Swanson JA, Misra S| title=Polyarteritis nodosa. | journal=Tech Vasc Interv Radiol | year= 2014 | volume= 17 | issue= 4 | pages= 247-51 | pmid=25770638 | doi=10.1053/j.tvir.2014.11.005 | pmc=4363102 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25770638 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[LAMP2|LAMP-2 protein autoantibodies]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normochromic anemia]], [[Thrombocytosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
| |
| ↑ [[ALT]] or [[AST]], [[Proteinuria]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal regions of [[infarction]] or [[hemorrhage]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Multiple [[Aneurysm|microaneurysms]], [[Hemorrhage]] due to focal [[rupture]], [[Occlusion]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]] and [[renal]] [[arteriovenous fistula]] in [[Doppler sonography|color Doppler sonography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Necrotizing]] [[inflammatory]] lesions
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Angiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Sudden [[weight loss]], [[Abdominal pain]]
| |
| |-
| |
| ! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis B virus]]-associated [[polyarteritis nodosa]]<ref name="pmid25755502">{{cite journal |vauthors=Sharma A, Sharma K |title=Hepatotropic viral infection associated systemic vasculitides-hepatitis B virus associated polyarteritis nodosa and hepatitis C virus associated cryoglobulinemic vasculitis |journal=J Clin Exp Hepatol |volume=3 |issue=3 |pages=204–12 |date=September 2013 |pmid=25755502 |pmc=4216827 |doi=10.1016/j.jceh.2013.06.001 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatitis B surface antigen|HBsAg]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normochromic anemia]], [[Thrombocytosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[ALT]] or [[AST]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal regions of [[infarction]] or [[hemorrhage]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms|Microaneurysms]] in [[mesenteric artery]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]] and [[renal]] [[arteriovenous fistula]] in [[Doppler sonography|color Doppler sonography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Necrotizing]] [[inflammatory]] lesions
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Angiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Peripheral neuropathy]], [[Livedo reticularis]]
| |
| |-
| |
| ! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Kawasaki disease]]<ref name="pmid21447126">{{cite journal| author=Takahashi K, Oharaseki T, Yokouchi Y| title=Pathogenesis of Kawasaki disease. | journal=Clin Exp Immunol | year= 2011 | volume= 164 Suppl 1 | issue= | pages= 20-2 | pmid=21447126 | doi=10.1111/j.1365-2249.2011.04361.x | pmc=3095860 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21447126 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[NT-proBNP]], [[Meprin A]], [[Filamin A interacting protein 1 like|Filamin C]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normochromic anemia]], ↑[[WBC]] with a [[left shift]], [[Thrombocytosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Acute phase reactant|Acute-phase reactants]], ↓[[Cholesterol]], ↓[[HDL]], ↓[[Apolipoprotein A1|ApolipoA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Coronary artery]] [[Calcification|calcifications]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Coronary artery aneurysm|Coronary artery aneurysms]], [[Coronary artery stenosis|stenosis]] or [[Coronary artery anomaly|occlusion]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Coronary artery anomaly]] in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Electron beam tomography|Electron beam CT (EBCT)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Acute destruction of the [[Tunica media|media]] by [[neutrophils]], with loss of [[elastic fibers]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Diarrhea]], [[Vomiting]]
| |
| |-
| |
| ! rowspan="10" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Infectious disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Parvovirus B19 infection]]<ref name="pmid12097253">{{cite journal| author=Heegaard ED, Brown KE| title=Human parvovirus B19. | journal=Clin Microbiol Rev | year= 2002 | volume= 15 | issue= 3 | pages= 485-505 | pmid=12097253 | doi= | pmc=118081 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12097253 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Parvovirus B19|B19]] [[DNA]], ↓[[Reticulocyte count]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |anti–[[parvovirus B19]] [[IgM]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hydrops]] in fetal [[ultrasonography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Parvovirus B19|B19]] [[DNA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Purpura|Purpuric rash]], [[Erythema multiforme]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Scarlet fever]]<ref name="pmid29081840">{{cite journal| author=Basetti S, Hodgson J, Rawson TM, Majeed A| title=Scarlet fever: a guide for general practitioners. | journal=London J Prim Care (Abingdon) | year= 2017 | volume= 9 | issue= 5 | pages= 77-79 | pmid=29081840 | doi=10.1080/17571472.2017.1365677 | pmc=5649319 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29081840 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antistreptococcal antibodies|Antistreptolysin-O (ASO) titers]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[CRP]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Thickened [[pulmonary]] markings if [[pneumonia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Sparse [[Neutropenia|neutrophilic]] [[Perivascular cell|perivascular infiltrate]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Sand-paper rashes, [[Sore throat]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Toxic shock syndrome]]<ref name="pmid22180682">{{cite journal| author=Vostral SL| title=Rely and Toxic Shock Syndrome: a technological health crisis. | journal=Yale J Biol Med | year= 2011 | volume= 84 | issue= 4 | pages= 447-59 | pmid=22180682 | doi= | pmc=3238331 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22180682 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Procalcitonin]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]] with [[left shift]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Myoglobinuria]], [[Pyuria|Sterile pyuria]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Acute respiratory distress syndrome]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Necrosis|Necrolysis]] of [[keratinocytes]] in [[epidermis]], Perivascular [[lymphocytic]] infiltrate
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical criteria
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Peeling or [[rashes]], Organ dysfunction
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Mononucleosis]]<ref name="pmid25774295">{{cite journal| author=Balfour HH, Dunmire SK, Hogquist KA| title=Infectious mononucleosis. | journal=Clin Transl Immunology | year= 2015 | volume= 4 | issue= 2 | pages= e33 | pmid=25774295 | doi=10.1038/cti.2015.1 | pmc=4346501 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25774295 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Epstein Barr virus|EBV]] [[DNA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Atypical lymphocyte]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Heterophile antibody test|Heterophile antibodies]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CNS Disease|CNS involvement]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Splenomegaly]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Encephalitis]] in [[MRI]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphoproliferative response]] in [[oropharynx]], [[Lymphocytic|Lymphocytic infiltration]] in [[spleen]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Heterophile antibody test]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Splenomegaly]], [[Palatal]] [[petechiae]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Leptospirosis]]<ref name="pmid11292640">{{cite journal |vauthors=Levett PN |title=Leptospirosis |journal=Clin. Microbiol. Rev. |volume=14 |issue=2 |pages=296–326 |date=April 2001 |pmid=11292640 |pmc=88975 |doi=10.1128/CMR.14.2.296-326.2001 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Interleukin 6|IL-6]], [[IL-8]] and [[IL-10]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
| |
| ↑[[ALT]] or [[AST]], [[Proteinuria]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" | Diffuse [[alveolar]] [[hemorrhage]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Toxin]]-mediated break down of [[endothelial cell]] membranes of [[capillaries]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Culture and the [[Agglutination|microscopic agglutination test]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Red eyes]], [[Skin rash]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Lyme disease|Lyme Disease]]<ref name="pmid23319969">{{cite journal| author=Biesiada G, Czepiel J, Leśniak MR, Garlicki A, Mach T| title=Lyme disease: review. | journal=Arch Med Sci | year= 2012 | volume= 8 | issue= 6 | pages= 978-82 | pmid=23319969 | doi=10.5114/aoms.2012.30948 | pmc=3542482 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23319969 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CXCL9|CXCL9 (MIG)]], [[CXCL10|CXCL10 (IP-10)]] and [[CCL19|CCL19 (MIP3B)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukopenia]], [[Thrombocytopenia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Microscopic hematuria]], [[Proteinuria]], ↑[[ALT]] or [[AST]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Punctate lesions in periventricular [[white matter]] in [[brain]] [[SPECT]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Acrodermatitis chronica atrophicans]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Serological testing|Serologic '''tests''']]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Erythema migrans]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Measles]]<ref name="pmid22510638">{{cite journal| author=White SJ, Boldt KL, Holditch SJ, Poland GA, Jacobson RM| title=Measles, mumps, and rubella. | journal=Clin Obstet Gynecol | year= 2012 | volume= 55 | issue= 2 | pages= 550-9 | pmid=22510638 | doi=10.1097/GRF.0b013e31824df256 | pmc=3334858 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22510638 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Measles]] [[Immunoglobulin M|IgM]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukopenia]], [[Lymphocytosis]], [[Thrombocytopenia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[ALT]] or [[AST]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pneumonia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Chest X-ray|CXR]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Spongiosis and vesiculation in the [[epidermis]] with scattered dyskeratotic [[keratinocytes]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[PCR]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rash|Generalized rash]], [[Cough]], [[Coryza]], or [[Conjunctivitis]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Rocky Mountain Spotted Fever]]<ref name="pmid2504480">{{cite journal| author=Walker DH| title=Rocky Mountain spotted fever: a disease in need of microbiological concern. | journal=Clin Microbiol Rev | year= 1989 | volume= 2 | issue= 3 | pages= 227-40 | pmid=2504480 | doi= | pmc=358117 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2504480 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |''[[Rickettsia rickettsii infection|R rickettsii]]'' [[serology]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thrombocytopenia]], [[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[ALT]] or [[AST]], [[Hyponatremia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Infarction]], [[edema]], and [[meningeal]] enhancement
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Myocardial]] or conduction abnormalities in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Immunofluorescent]] or [[immunoperoxidase]] staining of ''[[Rickettsia rickettsii infection|R rickettsii]]''
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical criteria and [[tick]] exposure
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Rash on the [[Palms of the hands|palms]] and [[soles]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Staphylococcal scalded skin syndrome|Staphylococcal Scalded Skin Syndrome]]<ref name="pmid27651848">{{cite journal| author=Mishra AK, Yadav P, Mishra A| title=A Systemic Review on Staphylococcal Scalded Skin Syndrome (SSSS): A Rare and Critical Disease of Neonates. | journal=Open Microbiol J | year= 2016 | volume= 10 | issue= | pages= 150-9 | pmid=27651848 | doi=10.2174/1874285801610010150 | pmc=5012080 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27651848 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Anti exfoliatin and [[Alpha toxin|anti alpha-toxin antibodies]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]] with [[left shift]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Blood culture]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pneumonia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Epidermal bullosa simplex|Intraepidermal blister]], dense superficial perivascular lymphohistiocytic infiltrate
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Blood culture]] and clinical findings
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Erythroderma|'''Widespread''' skin erythema]], [[Blisters|fluid-filled '''blisters''']]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Toxic Epidermal Necrolysis]]<ref name="pmid27239294">{{cite journal| author=Hoetzenecker W, Mehra T, Saulite I, Glatz M, Schmid-Grendelmeier P, Guenova E et al.| title=Toxic epidermal necrolysis. | journal=F1000Res | year= 2016 | volume= 5 | issue= | pages= | pmid=27239294 | doi=10.12688/f1000research.7574.1 | pmc=4879934 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27239294 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[MicroRNA|MicroRNA-124]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normocytic normochromic anemia|Normochromic normocytic anemia]], [[Eosinophilia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fluid loss]] and [[electrolyte abnormalities]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Tracheobronchial]] [[inflammation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Necrotic]] [[keratinocytes]] with full-thickness [[epithelial]] [[necrosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology]] and clinical findings
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Erythematous rash|Erythematous macular rash]] with [[purpuric]] centers
| |
| |-
| |
| ! rowspan="3" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cardiovascular disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Atrial Myxoma]]<ref name="pmid8407260">{{cite journal |vauthors=MacGowan SW, Sidhu P, Aherne T, Luke D, Wood AE, Neligan MC, McGovern E |title=Atrial myxoma: national incidence, diagnosis and surgical management |journal=Ir J Med Sci |volume=162 |issue=6 |pages=223–6 |date=June 1993 |pmid=8407260 |doi= |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Calretinin]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]], [[Leukocytosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Interleukin 6|IL-6]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Atrial]] filling defect larger than a [[thrombus]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Tumor]] location, size, attachment, and mobility in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Size, shape, and surface characteristics in [[MRI]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lipid|Lipidic]] cells embedded in a [[vascular]] myxoid stroma
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Dyspnea on exertion]], [[Syncope]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cholesterol Embolism]]<ref name="pmid21886725">{{cite journal| author=Avci G, Akoz T, Gul AE| title=Cutaneous cholesterol embolization. | journal=J Dermatol Case Rep | year= 2009 | volume= 3 | issue= 2 | pages= 27-9 | pmid=21886725 | doi=10.3315/jdcr.2009.1031 | pmc=3157794 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21886725 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Interleukin 5|IL-5]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]], [[Leukocytosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophiluria]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thoracic aorta|Thoracic]] and [[Abdominal aorta|abdominal aortic]] sources of [[embolism]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Atheroembolism]] in [[abdominal aorta]] and the [[lower extremity]] [[arteries]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Excluding an [[intracardiac]] source of [[embolism]] with [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Birefringent]] crystals or biconvex needle-shaped ghostly clefts within the [[arterial]] [[lumen]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Angiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Livedo reticularis]],
| |
| | |
| [[Ischemic|Ischemic patches]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Segmental arteries|Segmental arterial]] mediolysis<ref name="Chao2009">{{cite journal|last1=Chao|first1=Christine|title=Segmental Arterial Mediolysis|journal=Seminars in Interventional Radiology|volume=26|issue=03|year=2009|pages=224–232|issn=0739-9529|doi=10.1055/s-0029-1225666}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Visceral]] artery [[aneurysm]] in [[CT angiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Alternating [[aneurysms]] and [[stenoses]] (beading)
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Retroperitoneal hematoma]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Disruption of the [[smooth muscle]] in the [[Tunica media|media]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Angiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Ischemic colitis]]
| |
| |-
| |
| ! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Antiphospholipid syndrome|Antiphospholipid Syndrome]]<ref name="pmid26637701">{{cite journal| author=Chaturvedi S, McCrae KR| title=The antiphospholipid syndrome: still an enigma. | journal=Hematology Am Soc Hematol Educ Program | year= 2015 | volume= 2015 | issue= | pages= 53-60 | pmid=26637701 | doi=10.1182/asheducation-2015.1.53 | pmc=4877624 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26637701 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antiphospholipid antibodies]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thrombocytopenia]], [[Hemolytic anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lupus anticoagulant|Lupus anticoagulant (LA)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stroke]],
| |
| | |
| [[Pulmonary embolism]], [[Budd-Chiari syndrome]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thrombus]] in major [[vessels]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Valve thickening, vegetations, or insufficiency in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Noninflammatory bland [[thrombosis]] without perivascular [[inflammation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Hx of [[thrombosis]] and [[antiphospholipid antibodies]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Miscarriage]], [[Pulmonary hypertension]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Juvenile Idiopathic Arthritis]]<ref name="pmid22753788">{{cite journal |vauthors=Espinosa M, Gottlieb BS |title=Juvenile idiopathic arthritis |journal=Pediatr Rev |volume=33 |issue=7 |pages=303–13 |date=July 2012 |pmid=22753788 |doi=10.1542/pir.33-7-303 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rheumatoid factor|Rheumatoid factor (RF)]], [[S100A12]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphocytosis]], [[Thrombocytopenia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Myeloid-related proteins 8/14 (MRP8/14)
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Synovial]] [[hypertrophy]], Joint effusions
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebral vasculitis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Inflamed [[synovium]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bone scan|Bone scanning]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vascular congestion]], [[Extravasation|RBC extravasation]], Venular lumen occlusion
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Conventional [[radiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rash|Evanescent rash]], [[Dactylitis]]
| |
| |-
| |
| ! colspan="3" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
| |
| ! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |Fever
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Weight loss
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Arthralgia
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Claudication
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Bruit
| |
| ! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |HTN
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Focal neurological disorder
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Biomarker
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |CBC
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Histopathology
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
| |
| |-
| |
| ! rowspan="30" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Small-Vessel Vasculitis
| |
| ! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[ANCA-associated vasculitis]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Microscopic polyangiitis]]<ref name="pmid20688249">{{cite journal| author=Chung SA, Seo P| title=Microscopic polyangiitis. | journal=Rheum Dis Clin North Am | year= 2010 | volume= 36 | issue= 3 | pages= 545-58 | pmid=20688249 | doi=10.1016/j.rdc.2010.04.003 | pmc=2917831 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20688249 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C-ANCA|Anti-PR3 antibody (C-ANCA)]] (40%), [[P-ANCA|Anti-MPO antibody (P-ANCA)]] (60%)
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normocytic anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Proteinuria]], [[RBC casts|Erythrocyte casts]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Suspected [[pancreatitis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mesenteric]] [[angiography]] for differentiating from [[polyarteritis nodosa]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bilateral nodular, and patchy [[Opacity|opacities]] in [[Chest X-ray|CXR]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Glomerulonephritis]] with focal [[necrosis]], crescent formation, and lack or paucity of [[immunoglobulin]] deposits
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rash]], [[Hemoptysis]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Granulomatosis with polyangiitis|Granulomatosis with polyangiitis (Wegener’s)]]<ref name="pmid27195187">{{cite journal| author=Kubaisi B, Abu Samra K, Foster CS| title=Granulomatosis with polyangiitis (Wegener's disease): An updated review of ocular disease manifestations. | journal=Intractable Rare Dis Res | year= 2016 | volume= 5 | issue= 2 | pages= 61-9 | pmid=27195187 | doi=10.5582/irdr.2016.01014 | pmc=4869584 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27195187 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C-ANCA|Anti-PR3 antibody (C-ANCA)]] (90%), [[P-ANCA|Anti-MPO antibody (P-ANCA)]] (10%)
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normochromic anemia|Normochromic normocytic anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], [[Hypoalbuminemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Consolidation (medicine)|Consolidation]], Patchy or diffuse [[Ground glass opacification on CT|ground-glass opacities]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Occlusion]] or [[stenosis]] of [[LAD]] and [[RCA]] in [[coronary angiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Single or multiple [[nodules]] and [[Mass|masses]] with [[cavitation]] in [[CXR]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Parenchymal]] [[necrosis]], [[Granulomatous]] [[inflammation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Conjunctivitis]],
| |
| | |
| [[Episcleritis]],
| |
| | |
| [[Uveitis]],
| |
| | |
| [[Optic nerve]] vasculitis
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Eosinophilic granulomatosis with polyangiitis|Eosinophilic granulomatosis with polyangiitis]]
| |
| [[Eosinophilic granulomatosis with polyangiitis|(Churg-Strauss)]]<ref name="pmid16612766">{{cite journal |vauthors=Keogh KA, Specks U |title=Churg-Strauss syndrome |journal=Semin Respir Crit Care Med |volume=27 |issue=2 |pages=148–57 |date=April 2006 |pmid=16612766 |doi=10.1055/s-2006-939518 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[P-ANCA|Anti-MPO antibody (P-ANCA)]] (40%), Eotaxin-3
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]], [[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], [[Proteinuria]], [[RBC casts|Erythrocyte casts]], ↑[[Immunoglobulin E|IgE]] levels
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Significant enlargement of peripheral [[pulmonary arteries]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Myocardial ischemia]] and [[Myocardial infarction|infarction]] in [[coronary angiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Congestive heart failure|Congestive heart failure (CHF)]] in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Extensive air-space [[Opacity|opacities]] in [[CXR]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small [[necrotizing]] [[granulomas]] with [[eosinophilic]] core surrounded by [[macrophages]] and [[Epithelioid cell|epithelioid giant cells]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Allergic rhinitis]], [[Asthma]], [[Urticaria|Urticarial rash]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hydralazine]]-associated [[ANCA-associated vasculitis]]<ref name="pmid23316942">{{cite journal| author=Keasberry J, Frazier J, Isbel NM, Van Eps CL, Oliver K, Mudge DW| title=Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis presenting with a vasculitic syndrome, acute nephritis and a puzzling skin rash: a case report. | journal=J Med Case Rep | year= 2013 | volume= 7 | issue= | pages= 20 | pmid=23316942 | doi=10.1186/1752-1947-7-20 | pmc=3565908 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23316942 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[P-ANCA|Anti-MPO antibody (P-ANCA)]], Anti-histone antibodies
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], [[Hypoalbuminemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bilateral [[pulmonary]] infiltrates
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]] or [[Occlusion|occlusions]] of the [[Visceral|visceral arteries]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Pauci-immune [[necrotizing]] and [[crescentic glomerulonephritis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Sinusitis]], [[Hemoptysis]]
| |
| |-
| |
| ! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Immune complexes|Immune complex]] small-vessel vasculitis
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Goodpasture disease|Anti-glomerular basement membrane disease]]<ref name="pmid28515156">{{cite journal |vauthors=McAdoo SP, Pusey CD |title=Anti-Glomerular Basement Membrane Disease |journal=Clin J Am Soc Nephrol |volume=12 |issue=7 |pages=1162–1172 |date=July 2017 |pmid=28515156 |doi=10.2215/CJN.01380217 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-GBM antibody|Anti-GBM antibodies]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypochromic anemia|Hypochromic microcytic anemia]], [[Thrombocytopenia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↓[[C3 (complement)|C3]] level
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary hemorrhage]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal [[kidneys]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Alveolar]] infiltrates spreading from the [[hilum]] in [[CXR]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Cellular crescents in the [[glomeruli]], [[Pulmonary hemorrhage|Intra-alveolar hemorrhages]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-GBM antibody|Anti-GBM antibodies]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hemoptysis]], [[Hematuria]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cryoglobulinemia|Cryoglobulinemic vasculitis]]<ref name="pmid16344620">{{cite journal |vauthors=Ferri C, Mascia MT |title=Cryoglobulinemic vasculitis |journal=Curr Opin Rheumatol |volume=18 |issue=1 |pages=54–63 |date=January 2006 |pmid=16344620 |doi= |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C4A|C4 component]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antinuclear antibodies|ANA]], [[hypocomplementemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O underlying [[malignancy]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]] or [[Occlusion|occlusions]] of the [[Visceral|visceral arteries]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bacterial endocarditis]] in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Interstitial]] involvement or [[pleural effusions]] in [[CXR]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[HCV]]-associated [[proteins]] in [[vasculitic]] [[skin]], Intraluminal [[cryoglobulin]] deposits
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Acrocyanosis]], [[Retinal]] [[hemorrhage]], [[Purpura]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis C virus]]-associated [[Cryoglobulinemia|cryoglobulinemic vasculitis]]<ref name="pmid28810602">{{cite journal| author=Guo QY, Wu M, Wang YW, Sun GD| title=Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report. | journal=Exp Ther Med | year= 2017 | volume= 14 | issue= 2 | pages= 1395-1398 | pmid=28810602 | doi=10.3892/etm.2017.4671 | pmc=5525644 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28810602 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatitis C|HCV RNA]], [[Cryoglobulins]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↓[[C4A|Serum C4]], Positive [[RF]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[hepatic]] [[echogenicity]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[hepatic]] [[echogenicity]] in [[MRI]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vasculitic]] skin, [[Antigen]] infilteration in [[lesions]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatitis C|HCV RNA]], [[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Palpable [[purpura]], [[Microscopic hematuria]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Henoch-Schönlein purpura|IgA vasculitis (Henoch-Schönlein purpura)]]<ref name="pmid26990342">{{cite journal |vauthors=Farhadian JA, Castilla C, Shvartsbeyn M, Meehan SA, Neimann A, Pomeranz MK |title=IgA vasculitis (Henoch-Schönlein purpura) |journal=Dermatol. Online J. |volume=21 |issue=12 |pages= |date=December 2015 |pmid=26990342 |doi= |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normochromic anemia]], [[Leukocytosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Occult blood|Stool OB]], ↓[[C3 (complement)|C3]], ↓[[C4A|C4]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[bowel]] wall thickness, [[Hematoma|hematomas]], [[peritoneal fluid]], and [[intussusception]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Dilated loops of [[bowel]] consistent in [[abdominal X-ray]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytoclastic vasculitis]] in postcapillary [[venules]] with [[IgA]] deposition
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Purpura|Palpable purpura]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hypocomplementemia|Hypocomplementemic urticarial vasculitis (anti-C1q vasculitis)]]<ref name="pmid22328958">{{cite journal| author=Buck A, Christensen J, McCarty M| title=Hypocomplementemic urticarial vasculitis syndrome: a case report and literature review. | journal=J Clin Aesthet Dermatol | year= 2012 | volume= 5 | issue= 1 | pages= 36-46 | pmid=22328958 | doi= | pmc=3277093 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22328958 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C11orf1|C1q]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antinuclear antibodies|ANA]], ↓[[C10orf10|C1q]], ↓[[C3 (complement)|C3]], ↓[[C4A|C4]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Deposits of [[immunoglobulins]], [[complement]], or [[fibrin]] around [[blood vessels]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urticaria]],
| |
| | |
| [[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urticaria]], [[Hematuria]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Gastrointestinal diseases|Gastrointestinal disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Acute mesenteric ischemia]]<ref name="pmid24267504">{{cite journal |vauthors=Sise MJ |title=Acute mesenteric ischemia |journal=Surg. Clin. North Am. |volume=94 |issue=1 |pages=165–81 |date=February 2014 |pmid=24267504 |doi=10.1016/j.suc.2013.10.012 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[FABP1|I-FABP]], [[GSTA1|Alpha-GST]], [[Ischemia-modified albumin (IMA)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], ↑[[Hematocrit|HCT]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" | ↑[[Amylase]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bowel]] wall thickening, [[Pneumatosis intestinalis|Intestinal pneumatosis]], [[Mesenteric ischemia|Portomesenteric]] thrombosis
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mesenteric vein thrombosis|Mesenteric venous thrombosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Artery|Arterial]] [[stenosis]] or occlusion of the [[Celiac artery|celiac]] or [[superior mesenteric arteries]] in [[duplex ultrasound]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ileus]] with distended loops of [[bowel]], [[Bowel]] wall thickening in [[abdominal X-ray]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Superficial [[Mucosal bleeding|mucosal hemorrhage]], [[edema]] and [[necrosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Abdominal pain]], [[Distension]], [[Absent bowel sounds]]
| |
| |-
| |
| ! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cardiovascular diseases|Cardiovascular disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Infective Endocarditis]]<ref name="pmid19665088">{{cite journal| author=McDonald JR| title=Acute infective endocarditis. | journal=Infect Dis Clin North Am | year= 2009 | volume= 23 | issue= 3 | pages= 643-64 | pmid=19665088 | doi=10.1016/j.idc.2009.04.013 | pmc=2726828 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19665088 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[NT-proBNP]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normochromic anemia|Normochromic-normocytic anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypergammaglobulinemia|Hyperglobulinemia]], [[Cryoglobulinemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Metastatic]] [[infections]], such as [[Splenic infarction|splenic infarct]], [[Renal infarct|renal infarcts]], or [[psoas abscess]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vegetation (pathology)|Vegetation]], [[abscess]], or new dehiscence of a [[Prosthetic valves|prosthetic valve]]<nowiki/>in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vertebral osteomyelitis]] in [[Magnetic resonance imaging|MRI]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vegetation (pathology)|Vegetation]] or [[Abscess|intracardiac abscess]] demonstrating active [[endocarditis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Echocardiography]] ([[TTE]])
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Janeway lesions]], [[Osler nodes]], [[Roth's spot|Roth spots]], [[Vertebral osteomyelitis]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Leukocytoclastic vasculitis|Leukocytoclastic Vasculitis]]<ref name="pmid26176572">{{cite journal| author=Einhorn J, Levis JT| title=Dermatologic Diagnosis: Leukocytoclastic Vasculitis. | journal=Perm J | year= 2015 | volume= 19 | issue= 3 | pages= 77-8 | pmid=26176572 | doi=10.7812/TPP/15-001 | pmc=4500485 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26176572 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgM]], [[IgA]], [[Immunoglobulin G|IgG]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypocomplementemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vascular]] [[stenosis]] and [[obstruction]] in visceral [[Angiogram|angiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Perivascular [[inflammatory]] infiltrate of [[neutrophils]] with leukocytoclasia (releasing [[nuclear]] debris)
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Purpura|Palpable purpura]], [[Petechiae]]
| |
| |-
| |
| ! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pulmonary disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Langerhans Cell Histiocytosis]]<ref name="pmid18572052">{{cite journal |vauthors=Margo CE, Goldman DR |title=Langerhans cell histiocytosis |journal=Surv Ophthalmol |volume=53 |issue=4 |pages=332–58 |date=2008 |pmid=18572052 |doi=10.1016/j.survophthal.2008.04.007 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CD1a]], CD207,[[BRAF (gene)|BRAF-V600E]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypercalcemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary cystic lymphangiectasis|Pulmonary cysts]] and [[Pulmonary nodule|nodules]], [[Lytic|Bone lytic lesions]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebellum]] and [[pons]] hyperintensity in [[MRI]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Birbeck granules]] by [[electron microscopy]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Brown to purplish [[papules]], [[Eczematous Scaling|Eczematous rash]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Non small cell lung cancer|Non-Small Cell Lung Cancer]]<ref name="pmid18452692">{{cite journal| author=Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA| title=Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. | journal=Mayo Clin Proc | year= 2008 | volume= 83 | issue= 5 | pages= 584-94 | pmid=18452692 | doi=10.4065/83.5.584 | pmc=2718421 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18452692 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[EGFR]], ''[[ROS1]],'' [[Anaplastic lymphoma kinase|EML4-''ALK'']], [[PD-L1]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypercalcemia]], [[Hyponatremia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary|Pulmonary lesion]] or [[mass]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary]] marginal [[lesions]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cancer staging|Staging]] and response to treatment in [[Positron emission tomography|PET-CT]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Adenocarcinoma of the lung pathophysiology|Adenocarcinoma]], [[Squamous cell carcinoma of the lung pathophysiology|Squamous cell carcinoma]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Computed tomography|High resolution CT-scan]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Small cell lung cancer|Small Cell Lung Cancer]]<ref name="pmid16226617">{{cite journal |vauthors=Jackman DM, Johnson BE |title=Small-cell lung cancer |journal=Lancet |volume=366 |issue=9494 |pages=1385–96 |date=2005 |pmid=16226617 |doi=10.1016/S0140-6736(05)67569-1 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |''[[P53 (protein)|p53]],'' [[Thyroid transcription factor-1|Thyroid transcription factor-1 (TTF1)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hyponatremia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Large [[hilar]] mass with bulky [[mediastinal]] [[adenopathy]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Endobronchial [[ultrasound]] (EBUS)
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Standard [[Staging (pathology)|staging]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Spindled cells with dark [[nuclei]], scant [[cytoplasm]], and fine, granular [[Chromatin|nuclear chromatin]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Computed tomography|High resolution CT-scan]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pulmonary Infarction]]<ref name="pmid15821192">{{cite journal |vauthors=Parambil JG, Savci CD, Tazelaar HD, Ryu JH |title=Causes and presenting features of pulmonary infarctions in 43 cases identified by surgical lung biopsy |journal=Chest |volume=127 |issue=4 |pages=1178–83 |date=April 2005 |pmid=15821192 |doi=10.1378/chest.127.4.1178 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[D-dimer]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[leukocytosis]], Mild [[anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypoxemia]], [[Hypocarbia]] or [[Hypercarbia]], [[Respiratory alkalosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary embolism]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Low-[[density]] filling defect within the [[pulmonary artery]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pericardial effusion]] in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary]] infiltrates, [[atelectasis]], and [[pleural effusions]] in [[Chest X-ray|CXR]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Infarct]] induced [[apoptosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary artery]] [[angiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Renal disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Acute poststreptococcal glomerulonephritis|Acute Poststreptococcal Glomerulonephritis]]<ref name="pmid25554106">{{cite journal |vauthors=VanDeVoorde RG |title=Acute poststreptococcal glomerulonephritis: the most common acute glomerulonephritis |journal=Pediatr Rev |volume=36 |issue=1 |pages=3–12; quiz 13 |date=January 2015 |pmid=25554106 |doi=10.1542/pir.36-1-3 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antistreptococcal antibodies|Antistreptolysin-O (ASO) titers]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypocomplementemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal to slightly enlarged [[kidneys]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Central venous pressure|Central venous]] congestion in a [[hilar]] pattern in [[Chest X-ray|CXR]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Hypercellularity of [[Endothelial cells|endothelial]] and [[mesangial cells]], Infiltration of the [[glomerular]] tuft with [[polymorphonuclear cells]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]]
| |
| |-
| |
| ! rowspan="8" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hematologic disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hemolytic-uremic syndrome|Hemolytic-Uremic Syndrome]]<ref name="pmid11691946">{{cite journal |vauthors=Corrigan JJ, Boineau FG |title=Hemolytic-uremic syndrome |journal=Pediatr Rev |volume=22 |issue=11 |pages=365–9 |date=November 2001 |pmid=11691946 |doi= |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C5a|C5b-9]], [[ADAMTS13]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]], [[Reticulocytosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Lactate dehydrogenase|Lactate dehydrogenase (LDH)]], [[Hypercalcemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thalami]], [[brainstem]], or [[cerebellum]] abnormality
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebral]] [[microangiopathy]] or [[hypertension]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Hypoechoic [[kidney]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Abnormal hyperintensity in the [[Brain|brain cisterns]] in [[MRI]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thromboses|Microthromboses]] include [[Fibrin|fibrin thrombi]] that may occlude the [[glomerular]] tuft
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Proteinuria]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Chronic Lymphocytic Leukemia|Chronic Lymphocytic Leukemia (CLL)]]<ref name="pmid15561682">{{cite journal |vauthors=Byrd JC, Stilgenbauer S, Flinn IW |title=Chronic lymphocytic leukemia |journal=Hematology Am Soc Hematol Educ Program |volume= |issue= |pages=163–83 |date=2004 |pmid=15561682 |doi=10.1182/asheducation-2004.1.163 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CD5]], [[CD19]], [[CD20]], IgV<sub>H</sub>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Absolute [[lymphocytosis]], Smudge cells
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Flow cytometry]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cancer staging|Staging]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Large atypical [[Cells (biology)|cells]], cleaved cells, and [[prolymphocytes]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Chromosomal]] and [[genetic testing]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Multiple myeloma|Multiple Myeloma]]<ref name="pmid28318212">{{cite journal |vauthors=Michels TC, Petersen KE |title=Multiple Myeloma: Diagnosis and Treatment |journal=Am Fam Physician |volume=95 |issue=6 |pages=373–383 |date=March 2017 |pmid=28318212 |doi= |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Light chain|Ig light chain]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]], [[Leukopenia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bone marrow aspiration]] and [[biopsy]], ↑[[Cr]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Osseous]] involvement and [[Lytic|lytic lesions]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Peripheral zone of increased [[vascularity]] in lesions
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Punched-out lesion in [[X-ray|skull X-ray]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clonal proliferation of [[plasma cells]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Protein electrophoresis]] plus conventional [[X-rays]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Constipation]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hypereosinophilic syndrome|Hypereosinophilic Syndrome]]<ref name="pmid19630574">{{cite journal |vauthors=Klion A |title=Hypereosinophilic syndrome: current approach to diagnosis and treatment |journal=Annu. Rev. Med. |volume=60 |issue= |pages=293–306 |date=2009 |pmid=19630574 |doi=10.1146/annurev.med.60.062107.090340 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgE]], [[CD117]] with [[CD2]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑Serum [[tryptase]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphadenopathy]] and [[splenomegaly]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Intracardiac thrombus|Intracardiac thrombi]] in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Reticulin|Reticulin stain]] for [[myelofibrosis]] and [[tryptase]] staining for [[mast cells]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Splinter hemorrhages]], [[Raynaud phenomenon]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Non-Hodgkin lymphoma|Non-Hodgkin Lymphoma]]<ref name="pmid22835603">{{cite journal |vauthors=Shankland KR, Armitage JO, Hancock BW |title=Non-Hodgkin lymphoma |journal=Lancet |volume=380 |issue=9844 |pages=848–57 |date=September 2012 |pmid=22835603 |doi=10.1016/S0140-6736(12)60605-9 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C-myc|MYC]], [[BCL2-like 1 (gene)|BCL2]], [[BCL6]], and [[TP53]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphocytosis]], [[Anemia]], [[Thrombocytopenia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Lactate dehydrogenase|Lactate dehydrogenase (LDH)]], [[Hypercalcemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Enlarged [[Lymph node|lymph nodes]], [[Hepatosplenomegaly]], Filling defects in the [[liver]] and [[spleen]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatosplenomegaly]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mediastinal lymphadenopathy]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small cleaved or noncleaved, intermediate, or large cell with a follicular or diffuse pattern
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Surgically excised tissue [[biopsy]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]], [[Testicular mass]], [[Skin lesions|Skin lesion]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Serum sickness|Serum Sickness]]<ref name="pmid2867672">{{cite journal |vauthors=Lin RY |title=Serum sickness syndrome |journal=Am Fam Physician |volume=33 |issue=1 |pages=157–62 |date=January 1986 |pmid=2867672 |doi= |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IL-1]], [[IL-6]], [[TNF]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukopenia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Gammopathy|Polyclonal gammopathy]], ↑[[Cr]], [[Cryoglobulinemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Arteritic lesions are focal, [[necrotizing]], and [[inflammatory]] involving all layers of the [[artery]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Skin rash]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Disseminated intravascular coagulation|Disseminated Intravascular Coagulation]]<ref name="pmid25535423">{{cite journal| author=Venugopal A| title=Disseminated intravascular coagulation. | journal=Indian J Anaesth | year= 2014 | volume= 58 | issue= 5 | pages= 603-8 | pmid=25535423 | doi=10.4103/0019-5049.144666 | pmc=4260307 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25535423 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fibrin degradation product|Fibrin degradation product (FDP)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thrombocytopenia]], [[Schistocytes]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[D-dimer]], [[aPTT]] and [[PT]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Intracranial hemorrhage]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ischemia]] and [[necrosis]] due to [[Fibrin|fibrin deposition]] in small and medium-sized [[vessels]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Cyanosis|Acral cyanosis]], [[Hemorrhagic]] skin [[Infarction|infarctions]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Idiopathic thrombocytopenic purpura|Idiopathic Thrombocytopenic Purpura]]<ref name="pmid27441004">{{cite journal| author=Nomura S| title=Advances in Diagnosis and Treatments for Immune Thrombocytopenia. | journal=Clin Med Insights Blood Disord | year= 2016 | volume= 9 | issue= | pages= 15-22 | pmid=27441004 | doi=10.4137/CMBD.S39643 | pmc=4948655 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27441004 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[FCGR2B|FC gamma receptors (FCGR) IIb]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[HIV]], [[ANA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O other causes
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O [[splenomegaly]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased number of normal morphologic [[megakaryocytes]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[thrombocytopenia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]], [[Purpura]]
| |
| |-
| |
| ! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Sarcoidosis]]<ref name="pmid27454074">{{cite journal| author=Chiarchiaro J, Chen BB, Gibson KF| title=New molecular targets for the treatment of sarcoidosis. | journal=Curr Opin Pulm Med | year= 2016 | volume= 22 | issue= 5 | pages= 515-21 | pmid=27454074 | doi=10.1097/MCP.0000000000000304 | pmc=5152532 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27454074 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[IL-2]] and [[Interferon gamma|IFN-γ]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Angiotensin-converting enzyme|ACE]], ↑[[Vitamin D|1, 25-dihydroxyvitamin D]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Active [[alveolitis]] or [[fibrosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatosplenomegaly]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bilateral [[Adenopathy|hilar adenopathy]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Granuloma|Noncaseating granulomas (NCGs)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Heart block]], [[Ocular disease|Ocular lesion]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Legionella Infections|Legionella Infection]]<ref name="pmid12491204">{{cite journal |vauthors=Murdoch DR |title=Diagnosis of Legionella infection |journal=Clin. Infect. Dis. |volume=36 |issue=1 |pages=64–9 |date=January 2003 |pmid=12491204 |doi=10.1086/345529 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cytokine|Inflammatory cytokines]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]] with [[left shift]], [[Thrombocytosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[D-dimer]], [[Fibrin degradation product|FDP]], [[Hyponatremia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pleural effusion]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Nonspecific and indistinguishable [[CXR]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Intra-[[alveolar]] [[inflammation]], [[Abscesses|Microabscesses]] in the [[parenchyma]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Sputum culture]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Diarrhea]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic lupus erythematosus]]<ref name="Tsokos2011">{{cite journal|last1=Tsokos|first1=George C.|title=Systemic Lupus Erythematosus|journal=New England Journal of Medicine|volume=365|issue=22|year=2011|pages=2110–2121|issn=0028-4793|doi=10.1056/NEJMra1100359}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-dsDNA antibody|Anti dsDNA]], [[ANA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Leukopenia]], [[Lymphopenia]], [[Anemia]], [[Thrombocytopenia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
| |
| ↑[[ALT]] or [[AST]], [[Proteinuria]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Interstitial lung disease, [[Pneumonitis]], [[Pulmonary emboli]], [[Hemorrhage|Alveolar hemorrhage]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pericardial effusion]], [[pulmonary hypertension]], or verrucous [[Libman-Sacks endocarditis]] in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Central nervous system|Central nervous system (CNS)]] [[Systemic lupus erythematosus|lupus]] white-matter changes in [[MRI]]
| |
| ! align="center" style="padding: 5px 5px; background: #F5F5F5;" |Staging [[lupus nephritis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-dsDNA antibody|Anti-dsDNA antibody test]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Skin rashes]] or [[photosensitivity]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Rheumatoid arthritis]]<ref name="pmid16824912">{{cite journal| author=Scott JT| title=The gold standard in rheumatoid arthritis. | journal=J R Soc Med | year= 1991 | volume= 84 | issue= 9 | pages= 513-4 | pmid=1682491 | doi= | pmc=1293405 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1682491 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[RF]], [[Anti-citrullinated protein antibody|Anti-CCP antibody]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
| |
| ↑[[ALT]] or [[AST]], [[ANA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fractures|Microfractures]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Joint (anatomy)|Effusions in joints]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Basilar invagination with [[cranial]] migration of an eroded [[Odontoid process|odontoid]] peg in [[MRI]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Influx of [[inflammatory cells]] into the [[synovial membrane]], with [[angiogenesis]], proliferation of chronic [[inflammatory cells]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled [[Anti-citrullinated protein antibody|anti-CCP antibody]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rheumatoid nodules]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Relapsing polychondritis]]<ref name="pmid27708954">{{cite journal| author=Emmungil H, Aydın SZ| title=Relapsing polychondritis. | journal=Eur J Rheumatol | year= 2015 | volume= 2 | issue= 4 | pages= 155-159 | pmid=27708954 | doi=10.5152/eurjrheum.2015.0036 | pmc=5047229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27708954 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cryoglobulins]], [[ANA]], [[C-ANCA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Calcification]] of [[Cartilaginous|cartilaginous structures]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aortic root|Aortic root dilatation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aortic root|Aortic root dilatation]] and degree of [[aortic regurgitation]] in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Tracheal stenosis]] in [[CXR]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Chondrolysis, [[Chondritis]], Perichondritis
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with imaging
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ear pain]] and redness, [[Polyarthritis]]
| |
| |-
| |
| ! colspan="3" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
| |
| ! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |Fever
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Weight loss
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Arthralgia
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Claudication
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Bruit
| |
| ! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |HTN
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Focal neurological disorder
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Biomarker
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |CBC
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Histopathology
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
| |
| |-
| |
| ! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Variable-vessel vasculitis
| |
| ! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Behçet's disease|Behçet’s syndrome]]<ref name="pmid17334337">{{cite journal |vauthors=Yazici H, Fresko I, Yurdakul S |title=Behçet's syndrome: disease manifestations, management, and advances in treatment |journal=Nat Clin Pract Rheumatol |volume=3 |issue=3 |pages=148–55 |date=March 2007 |pmid=17334337 |doi=10.1038/ncprheum0436 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CXCL1]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]], [[Neutrophilia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Factor V Leiden]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal [[CNS]] lesions
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysm]] formation and [[thrombosis]] areas
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Valve [[Vegetation (pathology)|vegetations]] and [[Thrombi|ventricular thrombi]] in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Meningoencephalitis]] in [[MRI]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphocytic]] and [[plasma cell]] invasion in the [[prickle cell]] layer of the [[epidermis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical criteria
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Genital skin lesions|Genital ulcerations]], [[Oral ulcerations|Oral ulceration]]
| |
| |-
| |
| ! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cogan syndrome|Cogan's syndrome]]<ref name="pmid27373108">{{cite journal| author=Iliescu DA, Timaru CM, Batras M, De Simone A, Stefan C| title=COGAN'S SYNDROME. | journal=Rom J Ophthalmol | year= 2015 | volume= 59 | issue= 1 | pages= 6-13 | pmid=27373108 | doi= | pmc=5729811 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27373108 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Hsp70|Anti-Hsp70 antibodies]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[RF]], [[ANA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Thickening and enhancement of both posterior [[sclera]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Stenosis]], [[thrombosis]] or more lesions in [[aortic root]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aortic insufficiency]] in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Early [[interstitial keratitis]] by [[slit lamp]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Muscle]] [[necrosis]] and [[atrophy]] resembling [[myositis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |'''[[Red eye]], [[Hearing loss]], [[Vertigo]]'''
| |
| |-
| |
| ! rowspan="3" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Gastrointestinal diseases|Gastrointestinal disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Inflammatory bowel disease|Inflammatory Bowel Disease]]<ref name="pmid26900160">{{cite journal| author=Wehkamp J, Götz M, Herrlinger K, Steurer W, Stange EF| title=Inflammatory Bowel Disease. | journal=Dtsch Arztebl Int | year= 2016 | volume= 113 | issue= 5 | pages= 72-82 | pmid=26900160 | doi=10.3238/arztebl.2016.0072 | pmc=4782273 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26900160 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Anti-[[Saccharomyces cerevisiae|Saccharomyces cerevisiae antibody]] (ASCA), [[P-ANCA]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Iron deficiency anemia|Iron]] or [[vitamin deficiency]], [[Fecal occult blood|Stool OB]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mesenteric]] fat stranding, bowel wall enhancement, increased [[vascularity]] (comb sign)
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fistulas]], [[Abscesses]], [[Stenosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Grossly denuded [[Mucosal|mucosa]] with active [[bleeding]] in [[colonoscopy]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Crypt abscess|Crypt abscesses]] and [[Ulceration|mucosal ulceration]], [[Granulomas]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Endoscopy]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Gastrointestinal bleeding|GI bleeding]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Whipple's disease]]<ref name="pmid11432814">{{cite journal| author=Dutly F, Altwegg M| title=Whipple's disease and "Tropheryma whippelii". | journal=Clin Microbiol Rev | year= 2001 | volume= 14 | issue= 3 | pages= 561-83 | pmid=11432814 | doi=10.1128/CMR.14.3.561-583.2001 | pmc=88990 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11432814 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CCR4|CCR6]], [[Integrin, beta 6|Gut-homing marker integrin β7-chain]], ''[[Tropheryma whipplei|T whippelii DNA]]''
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]], [[Neutrophilia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fecal fat|72-hour fecal fat determination]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Nonspecific [[malabsorption]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatosplenomegaly]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Periodic acid-Schiff]]–positive [[macrophages]] infiltration in [[lamina propria]] of the [[small bowel]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Broad-spectrum [[Polymerase chain reaction|PCR]] amplifications
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cachexia]],
| |
| | |
| [[Glossitis]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Sjögren's syndrome]]<ref name="pmid28610655">{{cite journal| author=Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T| title=The Diagnosis and Treatment of Sjögren's Syndrome. | journal=Dtsch Arztebl Int | year= 2017 | volume= 114 | issue= 20 | pages= 354-361 | pmid=28610655 | doi=10.3238/arztebl.2017.0354 | pmc=5471601 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28610655 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Anti-Ro and Anti-La, Anti-alpha-fodrin [[antibody]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]],
| |
| | |
| [[Leukopenia]],
| |
| | |
| [[Eosinophilia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypergammaglobulinemia]], Low [[bicarbonate]] level, [[Hypokalemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Salt and pepper or honeycomb appearance in [[parotid glands]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Multicystic or reticular pattern in [[atrophic]] [[salivary gland]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O [[Obstruction|obstructions]] or [[strictures]] with [[Sialography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal aggregates of [[lymphocytes]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Schirmer's test|Schirmer test]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Keratoconjunctivitis]], [[Gingival|Gingival inflammation]]
| |
| |-
| |
| ! rowspan="6" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Single-organ vasculitis
| |
| ! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Primary [[central nervous system]] [[vasculitis]]<ref name="pmid16575852">{{cite journal |vauthors=Benseler SM, Silverman E, Aviv RI, Schneider R, Armstrong D, Tyrrell PN, deVeber G |title=Primary central nervous system vasculitis in children |journal=Arthritis Rheum. |volume=54 |issue=4 |pages=1291–7 |date=April 2006 |pmid=16575852 |doi=10.1002/art.21766 |url=}}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Von Willebrand factor (vWF)|von Willebrand factor antigen (vWF)]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CSF]] [[pleocytosis]], predominantly [[lymphocytes]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebral]] [[Infarction|infarcts]] or [[hemorrhages]] with [[mass effect]], or [[hydrocephalus]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysm]] in [[circle of Willis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Progression of the disease or response to therapy in [[MRI]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Chronic [[granulomatous]] [[inflammation]] and [[giant cells]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Skin rash]], [[Purpura]]
| |
| |-
| |
| ! rowspan="3" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Infectious disease]]
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Aspergillosis]]<ref name="pmid10194462">{{cite journal| author=Latgé JP| title=Aspergillus fumigatus and aspergillosis. | journal=Clin Microbiol Rev | year= 1999 | volume= 12 | issue= 2 | pages= 310-50 | pmid=10194462 | doi= | pmc=88920 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10194462 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aspergillus]] [[nucleic acid]] in [[blood]], [[Galactomannan]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑Serum [[Immunoglobulin E|IgE]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aspergilloma]] mass within a cavity
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mass effect]] [[stenosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aspergilloma]] mass within the brain in [[MRI]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Septate [[hyphae]], branching at acute angles, and tissue [[necrosis]] with [[Granuloma|granulomata]] and [[blood vessel]] invasion
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hemoptysis]], [[Aspergilloma]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Histoplasmosis]]<ref name="pmid20445761">{{cite journal| author=Guimarães AJ, Nosanchuk JD, Zancopé-Oliveira RM| title=DIAGNOSIS OF HISTOPLASMOSIS. | journal=Braz J Microbiol | year= 2006 | volume= 37 | issue= 1 | pages= 1-13 | pmid=20445761 | doi=10.1590/S1517-83822006000100001 | pmc=2863343 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20445761 }}</ref>
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Alkaline phosphatase|ALP]], ↑[[LDH]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebral]] [[histoplasmosis]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Valvular Diseases|Valvular involvement]] in [[echocardiography]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[PFTs|PFT]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Presence of [[yeast]] forms in tissue through [[Hematoxylin and eosin stain|hematoxylin and eosin staining]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Sputum cultures]]
| |
| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pneumonia]], [[Mediastinitis]]
| |
| |-
| |
| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Herpes Simplex Encephalitis]]<ref name="pmid9163027">{{cite journal |vauthors=Sköldenberg B |title=Herpes simplex encephalitis |journal=Scand J Infect Dis Suppl |volume=100 |issue= |pages=8–13 |date=1996 |pmid=9163027 |doi= |url=}}</ref>
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Herpes simplex virus|HSV]] [[DNA]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[lymphocytosis]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CSF]] [[pleocytosis]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Low-density lesions in the [[Temporal lobe|temporal]] and/or [[frontal lobe]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hemorrhagic]] lesion in [[white matter]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Multinucleated giant cell|Multinuclear giant cells]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[PCR]] or [[brain biopsy]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Seizures]],
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| [[Vomiting]]
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| ! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic diseases|Systemic disease]]
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| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Eclampsia]]<ref name="pmid21822394">{{cite journal| author=Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM| title=Pre-eclampsia: pathophysiology, diagnosis, and management. | journal=Vasc Health Risk Manag | year= 2011 | volume= 7 | issue= | pages= 467-74 | pmid=21822394 | doi=10.2147/VHRM.S20181 | pmc=3148420 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21822394 }}</ref>
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vascular endothelial growth factor|VEGF]], [[PlGF]], Soluble [[FLT1|FLT-1]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]], [[Schistocytes]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Bilirubin]], ↓[[Haptoglobin]], ↑[[Lactate dehydrogenase|LDH]], ↑[[Creatinine|Cr]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Cortical hypodense areas in the [[Occipital lobe|occipital lobes]], Diffuse [[cerebral edema]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fetal growth retardation|Poor fetal growth]], [[Oligohydramnios]], Abnormal [[umbilical artery]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased signal at the [[Gray matter|gray-white matter junction]] in [[MRI]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urinalysis|24-hour urine study]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Seizure]], [[Edema]]
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| |-
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| ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Fibromuscular dysplasia]]<ref name="pmid17555581" />
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Transforming growth factor β|Transforming growth factor β (TGF-β)]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Alternating [[stenosis]] and [[Dilatation|dilatations]] in [[CT angiography]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]] in the [[renal arteries]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Luminal narrowing alternating with [[dilatation]] (Beads sign)
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal [[concentric]], long-segment [[tubular]] [[stenosis]] or outpouching in [[MRA]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Fibrodysplastic changes, [[Collagen]] deposition
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Digital subtraction angiography|Digital subtraction angiography (DSA)]]
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| ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Spontaneous coronary artery dissection|Spontaneous coronary artery dissection (SCAD)]]
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| |-
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| |}
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