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| '''For the WikiDoc page for this topic, click [[Endometriosis|here]]'''
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| {{Endometriosis (patient information)}}
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| '''Editor-in-Chief:''' [[C. Michael Gibson]], M.S.,M.D. [mailto:charlesmichaelgibson@gmail.com] Phone:617-632-7753; '''Associate Editor(s)-In-Chief:''' [[Lakshmi Gopalakrishnan]], M.B.B.S.
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| ==Overview==
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| *Endometriosis is a condition in which the tissue that behaves like the cells lining the uterus (endometrium) grows in other areas of the body, causing pain, irregular bleeding, and possible [[infertility (patient information)|infertility]].
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| *The tissue growth (implant) typically occurs in the pelvic area, outside of the uterus, on the ovaries, bowel, rectum, bladder, and the delicate lining of the pelvis. However, the implants can occur in other areas of the body, too.
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| ==What are the symptoms of Endometriosis?==
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| Pain is the main symptom for women with endometriosis. This can include:
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| *[[Dysmenorrhea (patient information)|Painful periods]]
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| *Pain in the lower abdomen or pelvic cramps that can be felt for a week or two ''before menstruation''
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| *Pain in the lower abdomen ''felt during menstruation'' (the pain and cramps may be steady and dull or severe)
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| *[[Dyspareunia (patient information)|Pain during or following sexual intercourse]]
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| *Pain with bowel movements
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| *Pelvic or low back pain that may occur at any time during the menstrual cycle
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| *Note: '''Often there are no symptoms'''. In fact, some women with severe cases of endometriosis have no pain at all, whereas some women with mild endometriosis have severe pain.
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| ==What causes Endometriosis?==
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| *Each month a woman's ovaries produce hormones that stimulate the cells of the uterine lining (endometrium) to multiply and prepare for a fertilized egg. The lining swells and gets thicker.
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| *If these cells (called endometrial cells) grow outside the uterus, endometriosis results. Unlike cells normally found in the uterus that are shed during menstruation, the ones outside the uterus stay in place. They sometimes bleed a little bit, but they heal and are stimulated again during the next cycle.
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| *This ongoing process leads to symptoms of endometriosis ('''pain''') and can cause scars ('''adhesions''') on the tubes, ovaries, and surrounding structures in the pelvis.
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| *The cause of endometriosis is unknown, but there are a number of theories. One theory is that the endometrial cells loosened during menstruation may "back up" through the fallopian tubes into the pelvis. Once there, they implant and grow in the pelvic or abdominal cavities. This is called '''retrograde menstruation'''. This happens in many women, but there may be something different about the immune system in women who develop endometriosis compared to those who do not get the condition.
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| *Endometriosis is a common problem. Sometimes, it may '''run in the family'''. Although endometriosis is typically diagnosed between ages 25 - 35, the condition probably begins about the time that regular menstruation begins.
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| ==Who is at highest risk?==
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| *A woman who has a mother or sister with endometriosis is six times more likely to develop endometriosis than women in the general population.
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| *Other possible risk factors include:
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| :*Starting menstruation at an early age
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| :*Never having had children
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| :*Frequent menstrual cycles
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| :*Periods that last 7 or more days
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| :*Problems such as a closed hyman, which blocks the flow of menstrual blood during the period
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| ==When to seek urgent medical care?==
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| Call for an appointment with your health care provider if:
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| *You have symptoms of endometriosis
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| *Back pain or other symptoms come back after endometriosis is treated
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| *Consider getting '''screened for endometriosis''' if your mother or sister has been diagnosed with endometriosis, or if you are unable to become pregnant after trying for 1 year.
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| ==Diagnosis==
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| Tests that are done to diagnose endometriosis include:
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| *Pelvic exam
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| *Transvaginal ultrasound
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| *Pelvic laparoscopy
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| ==Treatment options==
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| *Treatment '''options include:'''
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| :*Medications to control pain
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| :*Medications to stop the endometriosis from getting worse
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| :*Surgery to remove the areas of endometriosis
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| :*Hysterectomy with removal of both ovaries
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| *'''Treatment depends on''' the following factors:
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| :*Age
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| :*Severity of symptoms
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| :*Severity of disease
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| :*Whether you want children in the future
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| *Some women who do not ever want children and have '''mild disease''' and symptoms may choose to just have regular exams every 6 - 12 months so the doctor can make sure the disease isn't getting worse. They may manage the symptoms by using:
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| :*Exercise and relaxation techniques
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| :*[[Non-steroidal anti-inflammatory drug|Nonsteroidal anti-inflammatory drugs]] (NSAIDs), such as [[ibuprofen]] (Advil) and [[naproxen]] (Aleve), [[acetaminophen]] (Tylenol), or prescription painkillers to relieve cramping and pain.
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| *Treatment may involve stopping the menstrual cycle and creating a state resembling pregnancy. This is called '''pseudopregnancy'''. It can help prevent the disease from getting worse. It's done using [[Combined oral contraceptive pill|birth control pills]] containing estrogen and progesterone.
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| :*You take the medicine continuously for 6 - 9 months before stopping the medicine for a week to have a period.
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| :*Side effects include spotting of blood, breast tenderness, nausea, and other hormonal side effects.
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| :*This type of therapy relieves most endometriosis symptoms, but it does not prevent scarring from the disease. It also does not reverse any physical changes that have already occurred.
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| *Another treatment involves '''[[Progestogen only pill|progesterone pills]]''' or injections. Side effects may be bothersome and include [[Clinical depression (patient information)|depression]], [[weight gain]], and spotting of blood.
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| *Some women may be prescribed medicines that stop the ovaries from producing estrogen. These medicines are called '''[[Gonadotropin-releasing hormone agonist|gonadotropin agonist]]''' drugs and include [[Nafarelin (patient information)|nafarelin acetate]] (Synarel) and Depo [[Leuprolide (patient information)|Lupron]].
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| :*Potential side effects include menopausal symptoms such as [[hot flashes]], vaginal dryness, mood changes, and [[Osteoporosis (patient information)|early loss of calcium from the bones]].
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| :*Because of the bone density loss, this type of treatment is usually limited to 6 months. In some cases, it may be extended up to 1 year if small doses of estrogen and progesterone are given to reduce the bone weakening side effects.
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| *Surgery is an option for women who have severe pain that does not improve with hormone treatment, or who want to become pregnant either now or in the future.
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| :*'''Pelvic laparoscopy or laparotomy''' is done to diagnose endometriosis and then remove or destroy all of endometriosis-related tissue and scar tissue (adhesions).
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| :*Women with severe symptoms or disease who do not want children in the future may have surgery to remove the uterus ('''hysterectomy'''). One or both ovaries and fallopian tubes may also be removed. One out of three women who do not have both of their ovaries removed at the time of hysterectomy will have their symptoms return and will need to have surgery at a later time to remove the ovaries.
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| ==Where to find medical care for Endometriosis?==
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| [http://maps.google.com/maps?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|map+top+hospital+Endometriosis}}}}&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&ie=UTF-8&sa=N&hl=en&tab=wl Directions to Hospitals Treating Endometriosis]
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| ==What to expect (Outlook/Prognosis)?==
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| *Hormone therapy and pelvic laparoscopy cannot cure endometriosis. However, it can partially or completely relieve symptoms in many patients for a number of years.
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| *Removing the uterus (hysterectomy), both ovaries and tubes give the best chance of a cure for endometriosis. You may need [[hormone replacement therapy for menopause]] after your ovaries are removed. Rarely endometriosis can come back, even after a hysterectomy.
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| *Endometriosis may result in [[Infertility (patient information)|infertility]], but not in every patient, and especially if the endometriosis is mild. Laparoscopic surgery may help improve fertility. The chance of success depends on the severity of the endometriosis. If the first surgery does not aid in getting pregnant, repeating the laparoscopy is unlikely to help. Patients should consider further infertility treatments.
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| ==Possible complications==
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| *Endometriosis can lead to problems getting pregnant ('''[[infertility (patient information)|infertility]]''').
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| *Other complications include:
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| :*Chronic or long-term '''pelvic pain''' that interferes with social and work activities
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| :*Large cysts in the pelvis (called '''endometriomas''') that may break open (rupture)
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| *Other complications are rare. In a few cases, endometriosis implants may cause blockages of the gastrointestinal or urinary tracts.
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| *Very rarely, cancer may develop in the areas of endometriosis after [[Menopause (patient information)|menopause]].
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| ==Prevention==
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| '''[[Oral contraceptive|Birth control pills]]''' may help to prevent or slow down the development of the disease.
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| ==Source==
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| http://www.nlm.nih.gov/medlineplus/ency/article/000915.htm
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| {{WH}}
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| {{WS}}
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| [[Category:For review]]
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| [[Category:Overview complete]]
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| [[Category:Template complete]]
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| [[Category:Disease]]
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| [[Category:Patient information]]
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| [[Category:Gynecology]]
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| [[Category:Gynecology patient information]]
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