Sandbox:Jaundice

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Differential diagnosis

Abbreviations: RUQ= Right upper quadrant of the abdomen, LFT= Liver function test, SIRS= Systemic inflammatory response syndrome, ERCP= Endoscopic retrograde cholangiopancreatography, N= Normal, AMA= Anti mitochondrial antibodies, LDH= Lactate dehydrogenase, GI= Gastrointestinal, CT= Computed tomography

Classification of jaundice based on etiology Disease History and clinical manifestations Diagnosis
Lab Findings Other blood tests Other diagnostic
Family history Fever RUQ Pain Pruritis AST ALT ALK BLR Indirect BLR Direct Viral serology
Jaundice Hepatocellular Jaundice Hemochromatosis + - -/+ - ↑/N ↑/N N - Ferritin ↑ Liver biopsy
Wilson's disease + - -/+ - N ↑/N N - Serum cerulloplasmin ↑ Liver biopsy
Viral hepatitis - -/+ - - N ↑/N N + Specific viral antibody for each type
Alcoholic hepatitis - - - - ↑↑ N ↑/N N - - style="padding: 5px 5px; background: #F5F5F5;" align="center" -
Drug induced hepatitis - -/+ - - N ↑/N N - - -
Autoimmune hepatitis -/+ - - -/+ N ↑/N N - Anti-LKM antibody Liver biopsy
Cholestatic Jaundice Common bile duct stone CT/ERCP
Hepatitis A cholestatic type Abdominal ultrasound
EBV / CMV hepatitis
Primary biliary cirrhosis
Primary sclerosing cholangitis
Isolated Jaundice Crigler-Najjar
Gilbert
Rotor syndrome
Dubin-Johnson syndrome
Hereditory spherocytosis
G6PD deficiency
Thalassemia
Sickle cell disease
Paroxismal nocturnal hemoglobinoria
Immune hemolysis