Sandbox:Jaundice

Differential diagnosis

Abbreviations: RUQ= Right upper quadrant of the abdomen, LFT= Liver function test, SIRS= Systemic inflammatory response syndrome, ERCP= Endoscopic retrograde cholangiopancreatography, N= Normal, AMA= Anti mitochondrial antibodies, LDH= Lactate dehydrogenase, GI= Gastrointestinal, CT= Computed tomography

Classification of jaundice based on etiology Disease History and clinical manifestations Diagnosis Lab Findings Other blood tests Other diagnostic Family history Fever RUQ Pain Pruritis AST ALT ALK BLR Indirect BLR Direct Viral serology Jaundice Hepatocellular Jaundice Hemochromatosis + - -/+ - ↑ ↑ ↑/N ↑/N N - Ferritin ↑ Liver biopsy Wilson's disease + - -/+ - ↑ ↑ N ↑/N N - Serum cerulloplasmin ↑ Liver biopsy Viral hepatitis - -/+ - - ↑ ↑ N ↑/N N + Specific viral antibody for each type Alcoholic hepatitis - - - - ↑ ↑↑ N ↑/N N - - style="padding: 5px 5px; background: #F5F5F5;" align="center" - Drug induced hepatitis - -/+ - - ↑ ↑ N ↑/N N - - - Autoimmune hepatitis -/+ - - -/+ ↑ ↑ N ↑/N N - Anti-LKM antibody Liver biopsy Cholestatic Jaundice Common bile duct stone CT/ERCP Hepatitis A cholestatic type Abdominal ultrasound EBV / CMV Primary biliary cirrhosis Primary sclerosing cholangitis Isolated Jaundice Crigler-Najjar Gilbert Rotor syndrome Dubin-Johnson syndrome Hereditory spherocytosis G6PD deficiency Thalassemia Sickle cell disease Paroxismal nocturnal hemoglobinoria Immune hemolysis