Sandbox:Jaundice: Difference between revisions

Latest revision as of 21:11, 5 January 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mehrian Jafarizade, M.D [2]

Differential diagnosis of jaundice

Abbreviations: RUQ= Right upper quadrant of the abdomen, LFT= Liver function test, SIRS= Systemic inflammatory response syndrome, ERCP= Endoscopic retrograde cholangiopancreatography, N= Normal, AMA= Anti mitochondrial antibodies, LDH= Lactate dehydrogenase, GI= Gastrointestinal, CT= Computed tomography

Classification of jaundice based on etiology		Disease	History and clinical manifestations				Diagnosis
			History and clinical manifestations				Lab Findings						Other blood tests	Other diagnostic
			Family history	Fever	RUQ Pain	Pruritis	AST	ALT	ALK	BLR Indirect	BLR Direct	Viral serology	Other blood tests	Other diagnostic
Jaundice	Hepatocellular Jaundice	Hemochromatosis	+	-	-/+	-	↑	↑	↑/N	↑/N	N	-	Ferritin ↑	Liver biopsy
		Wilson's disease	+	-	-/+	-	↑	↑	N	↑/N	N	-	Serum cerulloplasmin ↑	Liver biopsy
		Viral hepatitis	-	-/+	-	-	↑	↑	N	↑/N	N	+	Specific viral antibody for each type	-
		Alcoholic hepatitis	-	-/+	-/+	-	↑↑	↑	N	↑/N	N	-	-	-
		Drug induced hepatitis	-	-/+	-	-	↑	↑	N	↑/N	N	-	-	-
		Autoimmune hepatitis	-/+	-	-	-/+	↑	↑	N	↑/N	N	-	Anti-LKM antibody	Liver biopsy
		Cirrhosis	-/+	-/+	-/+	-	↑	↑	↑/N	↑/N	↑/N	-/+	Low platelet	Small liver on ultrasound
	Cholestatic Jaundice	Common bile duct stone	-/+	-	+	+	N	N	↑	N	↑	-	Dilated ducts on ultrasound	CT/ERCP
		Hepatitis A cholestatic type	-	-/+	+	+	N	N	↑	N	↑	+	HAV- AB	Abdominal ultrasound
		EBV / CMV hepatitis	-	-/+	+	+	N	N	↑	N	↑	+	Positive serology	-
		Primary biliary cirrhosis	-/+	-	-/+	+	N/↑	N/↑	↑	N	↑	-	AMA positive	Liver biopsy
		Primary sclerosing cholangitis	-/+	-	-/+	+	N/↑	N/↑	↑	N	↑	-	Beading on MRCP	Liver biopsy
		Pancreatic carcinoma	+	-	-/+	-	N/↑	N/↑	↑	N	↑	-	Mass on ultrasound	CT scan for diagnosis
	Isolated Jaundice	Crigler-Najjar type 2	+	-	-	-	N	N	N	↑	↑	-	Genetic testing
		Gilbert	+	-	-	-	N	N	N	↑	↑	-	Genetic testing
		Rotor syndrome	+	-	-	-	N	N	N	N	↑	-	Genetic testing	Liver biopsy
		Dubin-Johnson syndrome	+	-	-	-	N	N	N	N	↑	-	Genetic testing	Liver biopsy
		Hereditory spherocytosis	+	-	-/+	-	N	N	N	↑	N	-	Genetic testing	Osmotic fragility
		G6PD deficiency	+	-	-	-	N	N	N	↑	N	-	Genetic testing
		Thalassemia	+	-	-	-	N	N	N	↑	N	-	Genetic testing
		Sickle cell disease	+	-	-	-	N	N	N	↑	N	-	Genetic testing
		Paroxismal nocturnal hemoglobinoria	-	-	-	-	N	N	N	↑	N	-	Flocytometery
		Immune hemolysis	-	-/+	-	-	N	N	N	↑	N	-	Autoantibodies
		Hematoma	-	-/+	-	-	N	N	N	↑	N	-	Anemia	Truma or surgery in history

The differential diagnosis for jaundice and pruritis are:

				Lab Findings						Other blood tests	Other diagnostic
Disease	History and clinical manifestations			Diagnosis
				AST	ALT	ALK	BLR Indirect	BLR Direct	Viral serology
	Type of jaundice	Pruritis	Family history	AST	ALT	ALK	BLR Indirect	BLR Direct	Viral serology
Common bile duct stone	Cholestatic Jaundice	+	-/+	N	N	↑	N	↑	-	Dilated ducts on sono	CT/ERCP
Hepatitis A cholestatic type		+	-	N	N	↑	N	↑	+	HAV- AB	Abdominal ultrasound
EBV / CMV hepatitis		+	-	N	N	↑	N	↑	+	Positive serology	PCR or ELISA
Primary biliary cirrhosis		+	-/+	N/↑	N/↑	↑	N	↑	-	AMA positive	Liver biopsy
Primary sclerosing cholangitis		+	-/+	N/↑	N/↑	↑	N	↑	-	Beading on MRCP	Liver biopsy
Autoimmune hepatitis	Hepatocellular Jaundice	-/+	-/+	↑	↑	N	↑/N	N	-	Anti-LKM antibody	Liver biopsy

The differential diagnosis for jaundice, pruritis and RUQ pain are:

Disease	History and clinical manifestations					Diagnosis
						Lab Findings						Other blood tests	Other diagnostic
						AST	ALT	ALK	BLR Indirect	BLR Direct	Viral serology
	Type of jaundice	Pruritis	RUQ pain	Fever	Family history	AST	ALT	ALK	BLR Indirect	BLR Direct	Viral serology
Common bile duct stone	Cholestatic Jaundice	+	+	-	-/+	N	N	↑	N	↑	-	Dilated ducts on sono	CT/ERCP
Hepatitis A cholestatic type		+	+	-/+	-	N	N	↑	N	↑	+	HAV- AB	Abdominal ultrasound
EBV / CMV hepatitis		+	+	-/+	-	N	N	↑	N	↑	+	Positive serology	PCR or ELISA
Primary biliary cirrhosis		+	-/+	-	-/+	N/↑	N/↑	↑	N	↑	-	AMA positive	Liver biopsy
Primary sclerosing cholangitis		+	-/+	-	-/+	N/↑	N/↑	↑	N	↑	-	Beading on MRCP	Liver biopsy

The differential diagnosis for jaundice, pruritis and RUQ pain are:

Classification of jaundice based on etiology		Disease	History and clinical manifestations				Diagnosis
			History and clinical manifestations				Lab Findings						Other blood tests	Other diagnostic
			Family history	Fever	RUQ Pain	Pruritis	AST	ALT	ALK	BLR Indirect	BLR Direct	Viral serology	Other blood tests	Other diagnostic
Jaundice	Cholestatic Jaundice	Common bile duct stone	-/+	-	+	+	N	N	↑	N	↑	-	Dilated ducts on ultrasond	CT/ERCP
		Hepatitis A cholestatic type	-	-/+	+	+	N	N	↑	N	↑	+	HAV- AB	Abdominal ultrasound
		EBV / CMV hepatitis	-	-/+	+	+	N	N	↑	N	↑	+	Positive serology
		Primary biliary cirrhosis	-/+	-	-/+	+	N/↑	N/↑	↑	N	↑	-	AMA positive	Liver biopsy
		Primary sclerosing cholangitis	-/+	-	-/+	+	N/↑	N/↑	↑	N	↑	-	Beading on MRCP	Liver biopsy

The differential diagnosis for jaundice, fever and RUQ pain are:

Classification of jaundice based on etiology		Disease	History and clinical manifestations				Diagnosis
			History and clinical manifestations				Lab Findings						Other blood tests	Other diagnostic
			Family history	Fever	RUQ Pain	Pruritis	AST	ALT	ALK	BLR Indirect	BLR Direct	Viral serology	Other blood tests	Other diagnostic
Jaundice	Hepatocellular Jaundice	Alcoholic hepatitis	-	-/+	-/+	-	↑↑	↑	N	↑/N	N	-	-	-
	Hepatocellular Jaundice	Cirrhosis	-/+	-/+	-/+	-	↑	↑	↑/N	↑/N	↑/N	-/+	Low platate	Small liver on ultrasond
	Cholestatic Jaundice	Hepatitis A cholestatic type	-	-/+	+	+	N	N	↑	N	↑	+	HAV- AB	Abdominal ultrasound
	Cholestatic Jaundice	EBV / CMV hepatitis	-	-/+	+	+	N	N	↑	N	↑	+	Positive serology	PCR or ELISA

The differential diagnosis for jaundice and fever are:

Classification of jaundice based on etiology		Disease	History and clinical manifestations				Diagnosis
			History and clinical manifestations				Lab Findings						Other blood tests	Other diagnostic
			Family history	Fever	RUQ Pain	Pruritis	AST	ALT	ALK	BLR Indirect	BLR Direct	Viral serology	Other blood tests	Other diagnostic
Jaundice	Hepatocellular Jaundice	Viral hepatitis	-	-/+	-	-	↑	↑	N	↑/N	N	+	Specific viral antibody for each type	-
		Alcoholic hepatitis	-	-/+	-/+	-	↑↑	↑	N	↑/N	N	-	-	-
		Drug induced hepatitis	-	-/+	-	-	↑	↑	N	↑/N	N	-	-	-
		Cirrhosis	-/+	-/+	-/+	-	↑	↑	↑/N	↑/N	↑/N	-/+	Low platate	Small liver on ultrasond
	Cholestatic Jaundice	Hepatitis A cholestatic type	-	-/+	+	+	N	N	↑	N	↑	+	HAV- AB	Abdominal ultrasound
	Cholestatic Jaundice	EBV / CMV hepatitis	-	-/+	+	+	N	N	↑	N	↑	+	Positive serology	PCR or ELISA
	Isolated Jaundice	Immune hemolysis	-	-/+	-	-	N	N	N	↑	N	-	Autoantibodies
	Isolated Jaundice	Hematoma	-	-/+	-	-	N	N	N	↑	N	-	Anemia	Truma or surgery in history

@@ Line 1: / Line 1: @@
-==Differential diagnosis==
+{{CMG}}; {{AE}} {{MJ}}
+==Differential diagnosis of jaundice==
 <span style="font-size:85%">'''Abbreviations:'''
-'''[[RUQ]]'''= Right upper quadrant of the abdomen, '''LUQ'''= Left upper quadrant, '''LLQ'''= Left lower quadrant, '''RLQ'''= Right lower quadrant, '''LFT'''= Liver function test, SIRS= [[Systemic inflammatory response syndrome]], '''[[ERCP]]'''= [[Endoscopic retrograde cholangiopancreatography]], '''IV'''= Intravenous, '''N'''= Normal, '''AMA'''= Anti mitochondrial antibodies, '''[[LDH]]'''= [[Lactate dehydrogenase]], '''GI'''= Gastrointestinal, '''CXR'''= Chest X ray, '''IgA'''= [[Immunoglobulin A]], '''IgG'''= [[Immunoglobulin G]], '''IgM'''= [[Immunoglobulin M]], '''CT'''= [[Computed tomography]], '''[[PMN]]'''= Polymorphonuclear cells, '''[[ESR]]'''= [[Erythrocyte sedimentation rate]], '''[[CRP]]'''= [[C-reactive protein]]
+'''[[RUQ]]'''= Right upper quadrant of the abdomen, '''LFT'''= Liver function test, SIRS= [[Systemic inflammatory response syndrome]], '''[[ERCP]]'''= [[Endoscopic retrograde cholangiopancreatography]], '''N'''= Normal, '''AMA'''= Anti mitochondrial antibodies, '''[[LDH]]'''= [[Lactate dehydrogenase]], '''GI'''= Gastrointestinal, '''CT'''= [[Computed tomography]]</span><br>
-</span>
-<br>
 {| align="center"
@@ Line 9: / Line 9: @@
 |
 {| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
-! colspan="3" rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Classification of jaundice based on etiology
+! colspan="2" rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Classification of jaundice based on etiology
 ! rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Disease
-! colspan="8" align="center" style="background:#4479BA; color: #FFFFFF;" |Clinical manifestations
+! colspan="4" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |History and clinical manifestations
-! colspan="2" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Diagnosis
+! colspan="8" align="center" style="background:#4479BA; color: #FFFFFF;" |Diagnosis
-! rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Comments
+|-
+! colspan="6" align="center" style="background:#4479BA; color: #FFFFFF;" |Lab Findings
+! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Other blood tests
+! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Other diagnostic
+|-
+! rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |Family history
+! align="center" style="background:#4479BA; color: #FFFFFF;" |Fever
+! align="center" style="background:#4479BA; color: #FFFFFF;" |RUQ Pain
+! align="center" style="background:#4479BA; color: #FFFFFF;" |Pruritis
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |AST
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |ALT
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |ALK
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Indirect
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Direct
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |Viral serology
+|-
+! rowspan="25" align="center" style="background:#4479BA; color: #FFFFFF;" |Jaundice
+! colspan="1" rowspan="7" style="padding: 5px 5px; background: #DCDCDC;" align="center" | Hepatocellular Jaundice
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hemochromatosis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Ferritin ↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Wilson's disease
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Serum cerulloplasmin ↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Viral hepatitis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Specific viral antibody for each type
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Alcoholic hepatitis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Drug induced hepatitis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Autoimmune hepatitis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Anti-LKM antibody
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Cirrhosis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Low platelet
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small liver on ultrasound
+|-
+! rowspan="6" style="padding: 5px 5px; background: #DCDCDC;" align="center" | Cholestatic Jaundice
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Common bile duct stone
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Dilated ducts on ultrasound
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |CT/ERCP
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hepatitis A cholestatic type
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |HAV- AB
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Abdominal ultrasound
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |EBV / CMV hepatitis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Positive serology
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Primary biliary cirrhosis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |AMA positive
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Primary sclerosing cholangitis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Beading on MRCP
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Pancreatic carcinoma
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mass on ultrasound
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |CT scan for diagnosis
+|-
+! rowspan="11" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Isolated Jaundice
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Crigler-Najjar type 2
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Gilbert
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Rotor syndrome
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Dubin-Johnson syndrome
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hereditory spherocytosis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Osmotic fragility
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |G6PD deficiency
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Thalassemia
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Sickle cell disease
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Paroxismal nocturnal hemoglobinoria
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Flocytometery
 |-
-! colspan="4" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" | Symptoms
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Immune hemolysis
-! colspan="4" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" | Signs
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Autoantibodies
 |-
-! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" | Fever
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hematoma
-! align="center" style="background:#4479BA; color: #FFFFFF;" |Rigors and chills
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-! align="center" style="background:#4479BA; color: #FFFFFF;" |Abdominal Pain
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-! align="center" style="background:#4479BA; color: #FFFFFF;" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-! align="center" style="background:#4479BA; color: #FFFFFF;" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-! align="center" style="background:#4479BA; color: #FFFFFF;" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-! align="center" style="background:#4479BA; color: #FFFFFF;" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" | Lab Findings
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! align="center" style="background:#4479BA; color: #FFFFFF;" |Imaging
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Anemia
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Truma or surgery in history
 |-
-! rowspan="37" align="center" style="background:#4479BA; color: #FFFFFF;" |Hyperbilirubinema
+|}
-! colspan="1" rowspan="25" style="padding: 5px 5px; background: #DCDCDC;" align="center" | Inflammatory causes
+|}
-! rowspan="7" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Pancreato-biliary disorders
+'''The differential diagnosis for jaundice and pruritis are:'''
-| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" | Acute suppurative cholangitis
+{| align="center"
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+|-
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+|
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+{| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| rowspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" |Disease
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="3" rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |History and clinical manifestations
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="8" align="center" style="background:#4479BA; color: #FFFFFF;" |Diagnosis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+|-
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+! colspan="6" align="center" style="background:#4479BA; color: #FFFFFF;" |Lab Findings
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+! rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Other blood tests
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+! rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Other diagnostic
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+|-
+! colspan="1" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |AST
+! colspan="1" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |ALT
+! colspan="1" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |ALK
+! colspan="1" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Indirect
+! colspan="1" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Direct
+! colspan="1" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Viral serology
+|-
+| align="center" style="background:#4479BA; color: #FFFFFF;" |Type of jaundice
+| align="center" style="background:#4479BA; color: #FFFFFF;" |Pruritis
+| align="center" style="background:#4479BA; color: #FFFFFF;" |Family history
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Common bile duct stone
+! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" | '''Cholestatic Jaundice'''
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Dilated ducts on sono
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |CT/ERCP
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hepatitis A cholestatic type
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |HAV- AB
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Abdominal ultrasound
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |EBV / CMV hepatitis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Positive serology
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |PCR or ELISA
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Primary biliary cirrhosis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |AMA positive
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Primary sclerosing cholangitis
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Beading on MRCP
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
+|-
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Autoimmune hepatitis
+| rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |'''Hepatocellular Jaundice'''
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Anti-LKM antibody
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
+|-
+|}
+|}
+'''The differential diagnosis for jaundice, pruritis and RUQ pain are:'''
+{| align="center"
 |-
-| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" | [[Cholangitis|Acute cholangitis]]
+|
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+{| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! rowspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" |Disease
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="5" rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |History and clinical manifestations
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="8" align="center" style="background:#4479BA; color: #FFFFFF;" |Diagnosis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" | [[Acute cholecystitis|Acute cholecystitis]]
+! colspan="6" align="center" style="background:#4479BA; color: #FFFFFF;" |Lab Findings
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Other blood tests
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Other diagnostic
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |  [[Acute pancreatitis]]
+! colspan="1" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |AST
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |ALT
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |ALK
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Indirect
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Direct
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Viral serology
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Primary biliary cirrhosis]]
+! align="center" style="background:#4479BA; color: #FFFFFF;" |Type of jaundice
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |Pruritis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |RUQ pain
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |Fever
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |Family history
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Primary sclerosing cholangitis]]
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Common bile duct stone
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" | Cholestatic Jaundice
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Dilated ducts on sono
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |CT/ERCP
 |-
-| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cholelithiasis]]
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hepatitis A cholestatic type
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |HAV- AB
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Abdominal ultrasound
 |-
-! colspan="1" rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" | Gastric causes
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |EBV / CMV hepatitis
-| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" | [[Peptic Ulcer Disease|Peptic ulcer disease]]
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Positive serology
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |PCR or ELISA
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Gastritis|Gastritis]]
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Primary biliary cirrhosis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |AMA positive
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Gastroesophageal reflux disease|Gastroesophageal reflux disease]]
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Primary sclerosing cholangitis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Beading on MRCP
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Gastric outlet obstruction|Gastric outlet obstruction]]
+|}
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+|}
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+'''The differential diagnosis for jaundice, pruritis and RUQ pain are:'''
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+{| align="center"
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Gastrointestinal perforation]]
+|
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+{| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="2" rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Classification of jaundice based on etiology
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Disease
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="4" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |History and clinical manifestations
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="8" align="center" style="background:#4479BA; color: #FFFFFF;" |Diagnosis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-! rowspan="8" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Intestinal causes
+! colspan="6" align="center" style="background:#4479BA; color: #FFFFFF;" |Lab Findings
-| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Acute appendicitis]]
+! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Other blood tests
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Other diagnostic
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Diverticulitis|Acute diverticulitis]]
+! rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |Family history
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |Fever
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |RUQ Pain
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |Pruritis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |AST
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |ALT
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |ALK
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Indirect
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Direct
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |Viral serology
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Inflammatory bowel disease]]
+! rowspan="6" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Jaundice
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" | Cholestatic Jaundice
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Common bile duct stone
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Dilated ducts on ultrasond
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |CT/ERCP
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Irritable bowel syndrome]]
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hepatitis A cholestatic type
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |HAV- AB
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Abdominal ultrasound
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Whipple's disease]]
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |EBV / CMV hepatitis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Positive serology
 | style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Toxic megacolon]]
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Primary biliary cirrhosis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |AMA positive
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Tropical sprue]]
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Primary sclerosing cholangitis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Beading on MRCP
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Celiac disease]]
+|}
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+|}
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+'''The differential diagnosis for jaundice, fever and RUQ pain are:'''
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+{| align="center"
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hepatic causes
+|
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |
+{| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="2" rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Classification of jaundice based on etiology
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Disease
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="4" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |History and clinical manifestations
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="8" align="center" style="background:#4479BA; color: #FFFFFF;" |Diagnosis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |
+! colspan="6" align="center" style="background:#4479BA; color: #FFFFFF;" |Lab Findings
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Other blood tests
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Other diagnostic
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |
+! rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |Family history
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |Fever
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |RUQ Pain
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |Pruritis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |AST
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |ALT
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |ALK
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Indirect
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Direct
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |Viral serology
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |
+! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Jaundice
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hepatocellular Jaundice
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Alcoholic hepatitis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
 |-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" | Peritoneal causes
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Cirrhosis
-| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Low platate
-! style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small liver on ultrasond
 |-
-! colspan="2" rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" | Hollow Viscous Obstruction
+! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Cholestatic Jaundice
-| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Small intestine obstruction
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hepatitis A cholestatic type
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |HAV- AB
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Abdominal ultrasound
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Volvulus]]
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |EBV / CMV hepatitis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Positive serology
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |PCR or ELISA
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Biliary colic]]
+|}
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+|}
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+'''The differential diagnosis for jaundice and fever are:'''
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+{| align="center"
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Renal colic]]
+|
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+{| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="2" rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Classification of jaundice based on etiology
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Disease
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="4" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |History and clinical manifestations
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="8" align="center" style="background:#4479BA; color: #FFFFFF;" |Diagnosis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Vascular Disorders
+! colspan="6" align="center" style="background:#4479BA; color: #FFFFFF;" |Lab Findings
-! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Ischemic causes
+! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Other blood tests
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Mesenteric ischemia]]
+! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Other diagnostic
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Ischemic colitis|Acute ischemic colitis]]
+! rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |Family history
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |Fever
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |RUQ Pain
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! align="center" style="background:#4479BA; color: #FFFFFF;" |Pruritis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |AST
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |ALT
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |ALK
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Indirect
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Direct
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |Viral serology
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hemorrhagic causes
+! rowspan="9" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Jaundice
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Ruptured abdominal aortic aneurysm]]
+! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hepatocellular Jaundice
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Viral hepatitis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Specific viral antibody for each type
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |Intra-abdominal or [[retroperitoneal hemorrhage]]
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Alcoholic hepatitis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
 |-
-! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Gynaecological Causes
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Drug induced hepatitis
-! rowspan="3" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Tubal causes
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |Torsion of the cyst
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Salpingitis|Acute salpingitis]]
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Cirrhosis
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Low platate
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small liver on ultrasond
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |Cyst rupture
+! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Cholestatic Jaundice
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hepatitis A cholestatic type
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |HAV- AB
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Abdominal ultrasound
 |-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |Pregnancy
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |EBV / CMV hepatitis
-| style="padding: 5px 5px; background: #DCDCDC;" align="center" |Ruptured [[ectopic pregnancy]]
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Positive serology
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |PCR or ELISA
 |-
-! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Non-hyperbilirubinemia causes of jaundice (false jaundice)
+! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Isolated Jaundice
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |Rifampin use
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Immune hemolysis
-| colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pleural empyema]]
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Autoantibodies
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 |-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |Beta caroten
+| colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hematoma
-| colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Myocardial Infarction]]
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
-! style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
-! style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Anemia
-! style="padding: 5px 5px; background: #F5F5F5;" align="left" |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Truma or surgery in history
 |-
 |}
 |}

Sandbox:Jaundice: Difference between revisions

Latest revision as of 21:11, 5 January 2018

Differential diagnosis of jaundice

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