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Coagulation necrosis, characterized by | Coagulation necrosis, characterized by hypereosinophilia and nuclear pyknosis followed by karyorrhexis, karyolysis, total loss of nuclei, and loss of cytoplasmic cross-striations, is generally first visible in the period from 4-12 hours following infarction. Necrotic myocytes may retain their striations for a long time. Neutrophilic infiltration (acute inflammation), edema and hemorrhage are also first visible at 4-12 hours, but generally closer to 12 hours. The interstitium at the margin of the infarcted area is initially infiltrated with neutrophils, then with lymphocytes and macrophages who phagocytose or eat the myocyte debris. The necrotic area is surrounded and progressively invaded by granulation tissue: Which will replace the infarct with a fibrous or collagenous scar (which are typical steps in wound healing). The interstitial space or the space between cells, outside of blood vessels, may be infiltrated with red blood cells. Infiltration by macrophages, lymphocytes, eosinophils, fibroblasts, and capillaries begins around the periphery at 3-10 days. Contraction band necrosis, characterized by hypereosinophilic transverse bands of precipitated myofibrils in dead myocytes is usually seen at the edge of an Infarct or with reperfusion, for example with thrombolytic therapy. | ||
Neutrophilic infiltration ( | |||
Infiltration by macrophages, lymphocytes, eosinophils, fibroblasts and capillaries begins around the periphery at 3-10 days. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 18:53, 12 December 2017
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2], Usama Talib, BSc, MD [3]
Ovreview
Pathophysiology
Life cycle
Type 1
Type 2
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Coagulation necrosis, characterized by hypereosinophilia and nuclear pyknosis followed by karyorrhexis, karyolysis, total loss of nuclei, and loss of cytoplasmic cross-striations, is generally first visible in the period from 4-12 hours following infarction. Necrotic myocytes may retain their striations for a long time. Neutrophilic infiltration (acute inflammation), edema and hemorrhage are also first visible at 4-12 hours, but generally closer to 12 hours. The interstitium at the margin of the infarcted area is initially infiltrated with neutrophils, then with lymphocytes and macrophages who phagocytose or eat the myocyte debris. The necrotic area is surrounded and progressively invaded by granulation tissue: Which will replace the infarct with a fibrous or collagenous scar (which are typical steps in wound healing). The interstitial space or the space between cells, outside of blood vessels, may be infiltrated with red blood cells. Infiltration by macrophages, lymphocytes, eosinophils, fibroblasts, and capillaries begins around the periphery at 3-10 days. Contraction band necrosis, characterized by hypereosinophilic transverse bands of precipitated myofibrils in dead myocytes is usually seen at the edge of an Infarct or with reperfusion, for example with thrombolytic therapy.
References
- ↑ Murina F, Graziottin A, Felice R, Gambini D (2017). "Alpha Lipoic Acid Plus Omega-3 Fatty Acids for Vestibulodynia Associated With Painful Bladder Syndrome". J Obstet Gynaecol Can. 39 (3): 131–137. doi:10.1016/j.jogc.2016.12.035. PMID 28343553.
- ↑ Scholes D, Hooton TM, Roberts PL, Gupta K, Stapleton AE, Stamm WE (2005). "Risk factors associated with acute pyelonephritis in healthy women". Ann Intern Med. 142 (1): 20–7. PMC 3722605. PMID 15630106.