Sandbox:Aneeza

LIBMAN-SACK ENDOCARDITIS:

OVERVIEW:

Libman-sack endocarditis is the on of the cardiac manifestations of autoimmune systemic diseases most commonly Systemic Lupus Erythematosus

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High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.

Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders

Criteria	Symptomatic WM	Asymptomatic WM	IgM-Related Disorders	MGUS
IgM monoclonal protein	+	+	+	+
Bone marrow infiltration	+	+	-	-
Symptoms attributable to IgM	+	-	+	-
Symptoms attributable to tumor infiltration	+	-	-	-

Libman-Sacks endocarditis Microchapters
Overview
Historical Perspective
Pathophysiology
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Imaging Findings
Other Diagnostic Studies
Treatment
Differentiating Libman-Sacks Endocarditis from other Diseases