Sandbox/osteo

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Hematogenous Osteomyelitis

Empiric Therapy

▸ Click on the following categories to expand treatment regimens.

Age

  ▸  Newborn (<4 months)

  ▸  Children (>4 months) - Adults

  ▸  Adult (>21 years)

Staph aureus, gram-negative bacilli, group B strept
Preferred Regimen
Vancomycin 40 mg divided q6-8 hours
PLUS
Ceftazidime 50 mg IV q8h
OR
Cefepime 150 mg IV q8h
Alternative Regimen
Nafcillin
OR
Oxcacillin 37mg q6h
PLUS
Ceftazidime 2 gm IV q8h
OR
Cefepime 2 gm IV q12h
Staph aureus, group A strept, gram-negative bacilli
Preferred Regimen
Vancomycin 40 mg divided q6-8 hours
PLUS
Ceftazidime 50 mg IV q8h
OR
Cefepime 150 mg IV q8h
Alternative Regimen
Nafcillin
OR
Oxcacillin 37mg q6h
PLUS
Ceftazidime 2 gm IV q8h
OR
Cefepime 2 gm IV q12h
Staph aureus (most common)
Preferred Regimen
Vancomycin 1 gm IV q12h, if over 100 kg, 1.5 gm IV q12h
Alternative Regimen
Nafcillin 2 gm IV q4h
OR
Oxacillin 2 gm IV q4h